4O24
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2Q0 A 401 |
| Chain | Residue |
| A | ASN64 |
| A | PRO66 |
| A | LEU71 |
| A | LEU75 |
| A | TRP96 |
| A | LEU99 |
| A | PHE115 |
| B | PHE102 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2Q0 B 401 |
| Chain | Residue |
| B | ARG63 |
| B | ASN64 |
| B | PRO66 |
| B | LEU71 |
| B | LEU74 |
| B | HIS94 |
| B | LEU99 |
| B | PHE115 |
| A | PHE102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8U1N9, ECO:0000255|HAMAP-Rule:MF_02044 |
| Chain | Residue | Details |
| A | HIS94 | |
| B | HIS94 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G |
| Chain | Residue | Details |
| A | ASP14 | |
| A | HIS16 | |
| A | ASP58 | |
| A | HIS216 | |
| B | ASP14 | |
| B | HIS16 | |
| B | ASP58 | |
| B | HIS216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O4K |
| Chain | Residue | Details |
| A | HIS180 | |
| B | HIS180 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:4NZV |
| Chain | Residue | Details |
| A | HIS218 | |
| B | HIS218 |
