4I5L
Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation
Summary for 4I5L
Entry DOI | 10.2210/pdb4i5l/pdb |
Related | 2IE3 2NPP 3P71 4I5J 4I5K 4I5N |
Related PRD ID | PRD_001031 |
Descriptor | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, ... (9 entities in total) |
Functional Keywords | ef hand, phosphatase, cdc6 (substrate), hydrolase-toxin complex, hydrolase/toxin |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : P30153 P67775 Nucleus : Q99741 |
Total number of polymer chains | 8 |
Total formula weight | 299714.82 |
Authors | Wlodarchak, N.,Satyshur, K.A.,Guo, F.,Xing, Y. (deposition date: 2012-11-28, release date: 2013-05-08, Last modification date: 2023-11-15) |
Primary citation | Wlodarchak, N.,Guo, F.,Satyshur, K.A.,Jiang, L.,Jeffrey, P.D.,Sun, T.,Stanevich, V.,Mumby, M.C.,Xing, Y. Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res., 23:931-946, 2013 Cited by PubMed: 23752926DOI: 10.1038/cr.2013.77 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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