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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4I5L

Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000159cellular_componentprotein phosphatase type 2A complex
A0000775cellular_componentchromosome, centromeric region
A0000785cellular_componentchromatin
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006366biological_processtranscription by RNA polymerase II
A0006368biological_processtranscription elongation by RNA polymerase II
A0007059biological_processchromosome segregation
A0007143biological_processfemale meiotic nuclear division
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016328cellular_componentlateral plasma membrane
A0019888molecular_functionprotein phosphatase regulator activity
A0030425cellular_componentdendrite
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0040008biological_processregulation of growth
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043029biological_processT cell homeostasis
A0045202cellular_componentsynapse
A0045595biological_processregulation of cell differentiation
A0046982molecular_functionprotein heterodimerization activity
A0051225biological_processspindle assembly
A0051232biological_processmeiotic spindle elongation
A0051306biological_processmitotic sister chromatid separation
A0051754biological_processmeiotic sister chromatid cohesion, centromeric
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0065003biological_processprotein-containing complex assembly
A0070062cellular_componentextracellular exosome
A0090443cellular_componentFAR/SIN/STRIPAK complex
A0098978cellular_componentglutamatergic synapse
A0160232cellular_componentINTAC complex
A0160240biological_processRNA polymerase II transcription initiation surveillance
A1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
A1990405molecular_functionprotein antigen binding
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0005509molecular_functioncalcium ion binding
C0000159cellular_componentprotein phosphatase type 2A complex
C0000278biological_processmitotic cell cycle
C0000775cellular_componentchromosome, centromeric region
C0000785cellular_componentchromatin
C0000922cellular_componentspindle pole
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006357biological_processregulation of transcription by RNA polymerase II
C0006366biological_processtranscription by RNA polymerase II
C0006368biological_processtranscription elongation by RNA polymerase II
C0006470biological_processprotein dephosphorylation
C0007498biological_processmesoderm development
C0008287cellular_componentprotein serine/threonine phosphatase complex
C0010288biological_processresponse to lead ion
C0010719biological_processnegative regulation of epithelial to mesenchymal transition
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0031113biological_processregulation of microtubule polymerization
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0035970biological_processpeptidyl-threonine dephosphorylation
C0040008biological_processregulation of growth
C0043029biological_processT cell homeostasis
C0045121cellular_componentmembrane raft
C0045202cellular_componentsynapse
C0045595biological_processregulation of cell differentiation
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0048156molecular_functiontau protein binding
C0050811molecular_functionGABA receptor binding
C0051321biological_processmeiotic cell cycle
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090443cellular_componentFAR/SIN/STRIPAK complex
C0097706biological_processvascular endothelial cell response to oscillatory fluid shear stress
C0160232cellular_componentINTAC complex
C0160240biological_processRNA polymerase II transcription initiation surveillance
C0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
C0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
C0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
D0000159cellular_componentprotein phosphatase type 2A complex
D0000775cellular_componentchromosome, centromeric region
D0000785cellular_componentchromatin
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006366biological_processtranscription by RNA polymerase II
D0006368biological_processtranscription elongation by RNA polymerase II
D0007059biological_processchromosome segregation
D0007143biological_processfemale meiotic nuclear division
D0015630cellular_componentmicrotubule cytoskeleton
D0016020cellular_componentmembrane
D0016328cellular_componentlateral plasma membrane
D0019888molecular_functionprotein phosphatase regulator activity
D0030425cellular_componentdendrite
D0035331biological_processnegative regulation of hippo signaling
D0035556biological_processintracellular signal transduction
D0040008biological_processregulation of growth
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043029biological_processT cell homeostasis
D0045202cellular_componentsynapse
D0045595biological_processregulation of cell differentiation
D0046982molecular_functionprotein heterodimerization activity
D0051225biological_processspindle assembly
D0051232biological_processmeiotic spindle elongation
D0051306biological_processmitotic sister chromatid separation
D0051754biological_processmeiotic sister chromatid cohesion, centromeric
D0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0065003biological_processprotein-containing complex assembly
D0070062cellular_componentextracellular exosome
D0090443cellular_componentFAR/SIN/STRIPAK complex
D0098978cellular_componentglutamatergic synapse
D0160232cellular_componentINTAC complex
D0160240biological_processRNA polymerase II transcription initiation surveillance
D1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
D1990405molecular_functionprotein antigen binding
D2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
E0005509molecular_functioncalcium ion binding
F0000159cellular_componentprotein phosphatase type 2A complex
F0000278biological_processmitotic cell cycle
F0000775cellular_componentchromosome, centromeric region
F0000785cellular_componentchromatin
F0000922cellular_componentspindle pole
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0004725molecular_functionprotein tyrosine phosphatase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0006357biological_processregulation of transcription by RNA polymerase II
F0006366biological_processtranscription by RNA polymerase II
F0006368biological_processtranscription elongation by RNA polymerase II
F0006470biological_processprotein dephosphorylation
F0007498biological_processmesoderm development
F0008287cellular_componentprotein serine/threonine phosphatase complex
F0010288biological_processresponse to lead ion
F0010719biological_processnegative regulation of epithelial to mesenchymal transition
F0015630cellular_componentmicrotubule cytoskeleton
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0031113biological_processregulation of microtubule polymerization
F0035331biological_processnegative regulation of hippo signaling
F0035556biological_processintracellular signal transduction
F0035970biological_processpeptidyl-threonine dephosphorylation
F0040008biological_processregulation of growth
F0043029biological_processT cell homeostasis
F0045121cellular_componentmembrane raft
F0045202cellular_componentsynapse
F0045595biological_processregulation of cell differentiation
F0046872molecular_functionmetal ion binding
F0046982molecular_functionprotein heterodimerization activity
F0048156molecular_functiontau protein binding
F0050811molecular_functionGABA receptor binding
F0051321biological_processmeiotic cell cycle
F0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0070062cellular_componentextracellular exosome
F0090090biological_processnegative regulation of canonical Wnt signaling pathway
F0090443cellular_componentFAR/SIN/STRIPAK complex
F0097706biological_processvascular endothelial cell response to oscillatory fluid shear stress
F0160232cellular_componentINTAC complex
F0160240biological_processRNA polymerase II transcription initiation surveillance
F0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
F0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
F1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
F1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
F2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG A 601
ChainResidue
AGLU376
AARG381
AGLU410
AASP414
ALYS416
site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PEG A 602
ChainResidue
ASER214
AASP254
ALYS255
site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG A 603
ChainResidue
ALYS519
AHIS520
FHIS230
AHIS479
site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PEG A 604
ChainResidue
AALA136
AARG144
ATYR169
AASN172
AASP176
AHOH765
EPRO224
site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 601
ChainResidue
BASP401
BASP403
BASP405
BALA407
BGLU412
BHOH742
site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 602
ChainResidue
BASP327
BASP329
BASP331
BLEU333
BHOH740
BHOH762
site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PEG B 603
ChainResidue
BSER259
BTHR263
site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG B 604
ChainResidue
BARG362
BLYS365
BVAL366
BASP376
site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN C 401
ChainResidue
CASP85
CASN117
CHIS167
CHIS241
CMN402
CHOH559
site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN C 402
ChainResidue
CASP57
CHIS59
CASP85
CMN401
CHOH559
HHOH104
site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG C 403
ChainResidue
BLEU444
BLEU463
CTYR91
CARG135
CLYS136
site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG C 404
ChainResidue
CTHR40
CSER43
CASN44
CARG181
CARG185
site_idBC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MLI C 405
ChainResidue
CASN18
CPHE69
CLYS74
CSER75
CLEU99
CHOH557
site_idBC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PEG D 601
ChainResidue
DGLU297
DHOH714
site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG D 602
ChainResidue
DTYR456
DASN539
DLYS542
FASP77
site_idBC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA E 701
ChainResidue
EASP401
EASP403
EASP405
EALA407
EGLU412
EHOH838
site_idBC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA E 702
ChainResidue
EASP327
EASP329
EASP331
ELEU333
EHOH873
site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG E 703
ChainResidue
EGLN231
EGLU232
ESER259
ETHR263
site_idCC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MLI E 704
ChainResidue
EGLY180
EGLU189
EPRO236
EGLN239
EASP240
EASN243
site_idCC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN F 401
ChainResidue
FASP85
FASN117
FHIS167
FHIS241
FMN402
FHOH547
site_idCC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN F 402
ChainResidue
FHIS59
FASP85
FMN401
FHOH546
FHOH547
FASP57
site_idCC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MLI F 403
ChainResidue
FASN18
FPHE69
FLYS74
FHOH519
site_idCC5
Number of Residues13
DetailsBINDING SITE FOR CHAIN G OF MICROCYSTIN-LR (MCLR) BOUND FORM
ChainResidue
FARG89
FTYR127
FVAL189
FPRO190
FHIS191
FTRP200
FPRO213
FARG214
FTYR265
FCYS266
FCYS269
FHOH546
FHOH548
site_idCC6
Number of Residues15
DetailsBINDING SITE FOR CHAIN H OF MICROCYSTIN-LR (MCLR) BOUND FORM
ChainResidue
CARG89
CILE123
CTYR127
CVAL189
CPRO190
CHIS191
CTRP200
CPRO213
CARG214
CTYR265
CCYS266
CCYS269
CHOH532
HHOH101
HHOH104
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLDGDGALSmfEL
ChainResidueDetails
BASP401-LEU413
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
CLEU114-GLU119
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues76
DetailsRepeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues74
DetailsRepeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues76
DetailsRepeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues74
DetailsRepeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues76
DetailsRepeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsRepeat: {"description":"HEAT 6","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues76
DetailsRepeat: {"description":"HEAT 7","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues84
DetailsRepeat: {"description":"HEAT 8","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues76
DetailsRepeat: {"description":"HEAT 9","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues76
DetailsRepeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues76
DetailsRepeat: {"description":"HEAT 11","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues76
DetailsRepeat: {"description":"HEAT 12","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues76
DetailsRepeat: {"description":"HEAT 13","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues76
DetailsRepeat: {"description":"HEAT 14","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues66
DetailsRepeat: {"description":"HEAT 15","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues782
DetailsRegion: {"description":"PP2A subunit B binding"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues548
DetailsRegion: {"description":"Polyoma small and medium T antigens Binding"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues308
DetailsRegion: {"description":"SV40 small T antigen binding"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues378
DetailsRegion: {"description":"PP2A subunit C binding"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues70
DetailsDomain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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