4I5L
Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 584 | 64906.9 | 2 | UniProt (P30153) Pfam (PF02985) In PDB | Homo sapiens (human) | Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha |
2 | B, E | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct | polymer | 413 | 47227.2 | 2 | UniProt (Q9Y5P8) UniProt (Q99741) Pfam (PF21161) Pfam (PF17958) Pfam (PF13499) In PDB | Homo sapiens (human) | PP2A subunit B isoform PR48, Protein phosphatase 2A 48 kDa regulatory subunit |
3 | C, F | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha | polymer | 311 | 35780.3 | 2 | UniProt (P67775) Pfam (PF00149) In PDB | Homo sapiens (human) | PP2A-alpha, Replication protein C, RP-C |
4 | G, H | Microcystin-LR (MCLR) bound form | polymer | 7 | 1016.2 | 2 | NOR (NOR00109) BIRD (PRD_001031) | Microcystis aeruginosa | |
5 | A, B, C, D, E | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 11 | Chemie (PEG) | |||
6 | B, E | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
7 | F, C | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
8 | E, F, C | MALONATE ION | non-polymer | 102.0 | 3 | Chemie (MLI) | |||
9 | water | water | 18.0 | 531 | Chemie (HOH) |
Sequence modifications
B, E: 122 - 490 (UniProt: Q9Y5P8)
B, E: 512 - 532 (UniProt: Q99741)
PDB | External Database | Details |
---|---|---|
Ser 491 | - | linker |
Thr 492 | - | linker |
Gly 493 | - | linker |
Asn 494 | - | linker |
Ala 495 | - | linker |
Ser 496 | - | linker |
Asp 497 | - | linker |
Ser 498 | - | linker |
Ser 499 | - | linker |
Ser 500 | - | linker |
Asp 501 | - | linker |
Ser 502 | - | linker |
Ser 503 | - | linker |
Ser 504 | - | linker |
Ser 505 | - | linker |
Glu 506 | - | linker |
Gly 507 | - | linker |
Asp 508 | - | linker |
Gly 509 | - | linker |
Thr 510 | - | linker |
Val 511 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 297861.3 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 1853.5 | |
All* | Total formula weight | 299714.8 |