6TZ7

Crystal Structure of Aspergillus fumigatus Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus)

Summary for 6TZ7

• Entry DOI: 10.2210/pdb6tz7/pdb
• Descriptor: Serine/threonine-protein phosphatase 2B catalytic subunit, Calcineurin Ca2+-binding regulatory subunit CnaB, FK506-binding protein 1A, ... (10 entities in total)
• Functional Keywords: calcineurin, fk506, hydrolase-isomerase-calcium binding complex, hydrolase/isomerase/calcium binding
• Biological source: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100); More
• Total number of polymer chains: 3
• Total formula weight: 79808.44

Authors

Fox III, D.,Horanyi, P.S. (deposition date: 2019-08-10, release date: 2019-09-18, Last modification date: 2023-10-11)

• Primary citation: Juvvadi, P.R.,Fox 3rd, D.,Bobay, B.G.,Hoy, M.J.,Gobeil, S.M.C.,Venters, R.A.,Chang, Z.,Lin, J.J.,Averette, A.F.,Cole, D.C.,Barrington, B.C.,Wheaton, J.D.,Ciofani, M.,Trzoss, M.,Li, X.,Lee, S.C.,Chen, Y.L.,Mutz, M.,Spicer, L.D.,Schumacher, M.A.,Heitman, J.,Steinbach, W.J.; Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.; Nat Commun, 10:4275-4275, 2019; PubMed: 31537789; DOI: 10.1038/s41467-019-12199-1

Experimental method

X-RAY DIFFRACTION (2.5 Å)