3G33
| Crystal structure of CDK4/cyclin D3 | 分子名称: | CCND3 protein, Cell division protein kinase 4 | 著者 | Takaki, T, Echalier, A, Brown, N.R, Hunt, T, Endicott, J.A, Noble, M.E.M. | 登録日 | 2009-02-01 | 公開日 | 2009-03-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc.Natl.Acad.Sci.USA, 106, 2009
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3F5X
| CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site | 分子名称: | 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | 登録日 | 2008-11-04 | 公開日 | 2009-02-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg.Med.Chem.Lett., 19, 2009
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2W2H
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3EOC
| Cdk2/CyclinA complexed with a imidazo triazin-2-amine | 分子名称: | 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine, Cell division protein kinase 2, Cyclin-A2 | 著者 | Cheung, M, Kuntz, K, Pobanz, M, Salovich, J, Wilson, B, Andrews, W, Shewchuk, L, Epperly, A, Hassler, D, Leesnitzer, M, Smith, J, Smith, G, Lansing, T, Mook, R. | 登録日 | 2008-09-26 | 公開日 | 2008-11-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg.Med.Chem.Lett., 18, 2008
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3EJ1
| CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor | 分子名称: | Cell division protein kinase 2, Cyclin-A2, N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine | 著者 | Stevens, K, Reno, M, Alberti, J, Price, D, Kane-Carson, L, Knick, V, Shewchuk, L, Hassell, A, Veal, J, Peel, M. | 登録日 | 2008-09-17 | 公開日 | 2008-10-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
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3EID
| CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor | 分子名称: | (2S)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol, Cell division protein kinase 2, Cyclin-A2 | 著者 | Steven, K, Reno, M, Alberti, J, Price, D, Kane-Carson, L, Knick, V, Shewchuk, L, Hassell, A, Veal, J, Peel, M. | 登録日 | 2008-09-15 | 公開日 | 2008-10-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
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3DOG
| Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1 | 分子名称: | (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Echalier, A, Endicott, J. | 登録日 | 2008-07-04 | 公開日 | 2008-09-30 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine. Mol.Cancer Ther., 7, 2008
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3DDQ
| Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine | 分子名称: | Cell division protein kinase 2, Cyclin-A2, MONOTHIOGLYCEROL, ... | 著者 | Echalier, A, Endicott, J.A. | 登録日 | 2008-06-06 | 公開日 | 2008-07-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene, 27, 2008
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3DDP
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3BLH
| Crystal Structure of Human CDK9/cyclinT1 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein kinase 9, Cyclin-T1 | 著者 | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | 登録日 | 2007-12-11 | 公開日 | 2008-07-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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3BLR
| Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol | 分子名称: | 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Cell division protein kinase 9, Cyclin-T1, ... | 著者 | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | 登録日 | 2007-12-11 | 公開日 | 2008-07-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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3BLQ
| Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ... | 著者 | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | 登録日 | 2007-12-11 | 公開日 | 2008-07-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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3BHT
| Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3 | 分子名称: | 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. | 登録日 | 2007-11-29 | 公開日 | 2008-02-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
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3BHV
| Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B | 分子名称: | 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. | 登録日 | 2007-11-29 | 公開日 | 2008-02-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
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3BHU
| Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5 | 分子名称: | 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. | 登録日 | 2007-11-29 | 公開日 | 2008-02-12 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
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2V22
| REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE | 著者 | Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M. | 登録日 | 2007-05-31 | 公開日 | 2008-01-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors Chembiochem, 7, 2006
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2PK2
| Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat | 分子名称: | Cyclin-T1, Protein Tat | 著者 | Anand, K, Schulte, A, Fujinaga, K, Scheffzek, K, Geyer, M. | 登録日 | 2007-04-17 | 公開日 | 2007-07-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat. J.Mol.Biol., 370, 2007
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2UZB
| Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor | 分子名称: | 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2 | 著者 | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | 登録日 | 2007-04-27 | 公開日 | 2007-06-26 | 最終更新日 | 2019-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
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2UZD
| Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor | 分子名称: | 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 | 著者 | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | 登録日 | 2007-04-27 | 公開日 | 2007-06-26 | 最終更新日 | 2019-04-03 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
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2UZE
| Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor | 分子名称: | 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 | 著者 | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | 登録日 | 2007-04-27 | 公開日 | 2007-06-26 | 最終更新日 | 2019-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
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2UZL
| Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor | 分子名称: | 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 | 著者 | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | 登録日 | 2007-04-30 | 公開日 | 2007-06-26 | 最終更新日 | 2019-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
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2JGZ
| Crystal structure of phospho-CDK2 in complex with Cyclin B | 分子名称: | CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN-B1 | 著者 | Brown, N.R, Petri, E, Lowe, E.D, Skamnaki, V, Johnson, L.N. | 登録日 | 2007-02-17 | 公開日 | 2007-05-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Cyclin B and cyclin A confer different substrate recognition properties on CDK2. Cell Cycle, 6, 2007
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2UUE
| REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors | 分子名称: | 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID, 4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE, CELL DIVISION PROTEIN KINASE 2, ... | 著者 | Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M. | 登録日 | 2007-03-02 | 公開日 | 2007-03-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors Chembiochem, 7, 2006
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2I53
| Crystal structure of Cyclin K | 分子名称: | ACETATE ION, Cyclin K | 著者 | Baek, K, Brown, R.S, Birrane, G, Ladias, J.A.A. | 登録日 | 2006-08-23 | 公開日 | 2007-01-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9. J.Mol.Biol., 366, 2007
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2B9R
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