3EJ1
CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
Summary for 3EJ1
Entry DOI | 10.2210/pdb3ej1/pdb |
Related | 3EID |
Descriptor | Cell division protein kinase 2, Cyclin-A2, N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine (3 entities in total) |
Functional Keywords | cdk, cyclin, kinase, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 128192.55 |
Authors | Stevens, K.,Reno, M.,Alberti, J.,Price, D.,Kane-Carson, L.,Knick, V.,Shewchuk, L.,Hassell, A.,Veal, J.,Peel, M. (deposition date: 2008-09-17, release date: 2008-10-21, Last modification date: 2023-08-30) |
Primary citation | Stevens, K.L.,Reno, M.J.,Alberti, J.B.,Price, D.J.,Kane-Carson, L.S.,Knick, V.B.,Shewchuk, L.M.,Hassell, A.M.,Veal, J.M.,Davis, S.T.,Griffin, R.J.,Peel, M.R. Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18:5758-5762, 2008 Cited by PubMed: 18835709DOI: 10.1016/j.bmcl.2008.09.069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.22 Å) |
Structure validation
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