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PDB: 11 件
8EBL
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BU of 8ebl by Molmil
Structure of KLHDC2 substrate binding domain bound to C-degron from EPHB2
分子名称: GLU-ASP-SER-HIS-LYS-GLU-SER-ASN-ASP-CYS-SER-CYS-GLY-GLY, Kelch domain-containing protein 2
著者Scott, D.C, Schulman, B.A.
登録日2022-08-31
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8SGF
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BU of 8sgf by Molmil
KLHDC2 Kelch Domain with KLHDC2 c-terminal peptide bound
分子名称: GLYCEROL, HIS-SER-VAL-ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, Kelch domain-containing protein 2
著者Digianantonio, K.M, Bekes, M, Langley, D.R, Zimmerman, K.
登録日2023-04-12
公開日2024-01-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.418 Å)
主引用文献Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat.Struct.Mol.Biol., 31, 2024
8SGE
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BU of 8sge by Molmil
KLHDC2 Kelch Domain with ligand KDRLKZ-1
分子名称: GLYCEROL, Kelch domain-containing protein 2, [(5P)-5-{3-[(2R)-butan-2-yl]-7-[(2-methoxyethoxy)carbonyl]-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl}-2-oxopyridin-1(2H)-yl]acetic acid
著者Digianantonio, K.M, Bekes, M, Langley, D.R, Zimmerman, K.
登録日2023-04-12
公開日2024-01-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.509 Å)
主引用文献Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat.Struct.Mol.Biol., 31, 2024
8EBM
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BU of 8ebm by Molmil
Structure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimic
分子名称: ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, Kelch domain-containing protein 2
著者Scott, D.C, Schulman, B.A.
登録日2022-08-31
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8PIF
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BU of 8pif by Molmil
Fragment 12 in complex with KLHDC2
分子名称: 1,2-ETHANEDIOL, 2-(furan-3-yl)ethanoic acid, Kelch domain-containing protein 2
著者Boettcher, J, Mayer, M.
登録日2023-06-21
公開日2023-07-12
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.782 Å)
主引用文献KLHDC2 - The Next Level
To Be Published
8UXS
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BU of 8uxs by Molmil
KLHDC2 ubiquitin ligase in complex with a novel small-molecule
分子名称: Kelch domain-containing protein 2, {4-[(2-{[(4-tert-butylphenyl)methyl]sulfanyl}acetamido)methyl]-1H-1,2,3-triazol-1-yl}acetic acid
著者Rusnac, D.V, Zheng, N.
登録日2023-11-10
公開日2024-07-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献KLHDC2 ubiquitin ligase in complex with a novel small-molecule
To Be Published
6DO3
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BU of 6do3 by Molmil
KLHDC2 ubiquitin ligase in complex with SelK C-end degron
分子名称: Kelch domain-containing protein 2, SelK C-end Degron
著者Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N.
登録日2018-06-08
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.165 Å)
主引用文献Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
6DO4
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BU of 6do4 by Molmil
KLHDC2 ubiquitin ligase in complex with SelS C-end degron
分子名称: Kelch domain-containing protein 2, SELS C-END DEGRON
著者Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N.
登録日2018-06-08
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
6DO5
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BU of 6do5 by Molmil
KLHDC2 ubiquitin ligase in complex with USP1 C-end degron
分子名称: Kelch domain-containing protein 2, USP1 C-END DEGRON
著者Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N.
登録日2018-06-08
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
8EBN
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BU of 8ebn by Molmil
Structure of KLHDC2-EloB/C tetrameric assembly
分子名称: Elongin-B, Elongin-C, Kelch domain-containing protein 2
著者Scott, D.C, Schulman, B.A.
登録日2022-08-31
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
8SH2
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BU of 8sh2 by Molmil
KLHDC2 in complex with EloB and EloC
分子名称: Elongin-B, Elongin-C, Kelch domain-containing protein 2
著者Digianantonio, K.M, Bekes, M.
登録日2023-04-13
公開日2024-01-03
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.74 Å)
主引用文献Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat.Struct.Mol.Biol., 31, 2024

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件を2024-07-24に公開中

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