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PDB: 15 件
5NQZ
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BU of 5nqz by Molmil
Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 309.
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein, ...
著者Johnson, S, Hollingshead, S, Lea, S.M, Tang, C.M.
登録日2017-04-21
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
7LCV
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BU of 7lcv by Molmil
Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein
分子名称: CHLORIDE ION, Factor H binding protein, Immunoglobulin heavy chain Fd fragment, ...
著者Beernink, P.T, Sands, N.
登録日2021-01-11
公開日2021-06-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.
Plos Pathog., 17, 2021
2YPV
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BU of 2ypv by Molmil
Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody
分子名称: 1,2-ETHANEDIOL, FAB 12C1, LIPOPROTEIN
著者Malito, E, Veggi, D, Bottomley, M.J.
登録日2012-11-01
公開日2013-02-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Defining a Protective Epitope on Factor H Binding Protein, a Key Meningococcal Virulence Factor and Vaccine Antigen.
Proc.Natl.Acad.Sci.USA, 110, 2013
2Y7S
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BU of 2y7s by Molmil
Structure of a designed meningococcal antigen (factor H binding protein, mutant G1) inducing broad protective immunity
分子名称: FACTOR H BINDING PROTEIN
著者Malito, E, Spraggon, G, Bottomley, M.J.
登録日2011-02-01
公開日2011-07-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity.
Sci.Transl.Med, 3, 2011
7KET
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BU of 7ket by Molmil
Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein
分子名称: Factor H binding protein, Immunoglobulin gamma, heavy chain Fd fragment, ...
著者Beernink, P.T, Sands, N.
登録日2020-10-12
公開日2021-06-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.
Plos Pathog., 17, 2021
5O14
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BU of 5o14 by Molmil
Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Fab 1A12 Heavy Chain, ...
著者Lopez-Sagaseta, J.
登録日2017-05-18
公開日2018-02-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.195 Å)
主引用文献Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
Nat Commun, 9, 2018
2W80
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BU of 2w80 by Molmil
Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H
分子名称: COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
著者Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M.
登録日2009-01-08
公開日2009-03-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009
2W81
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BU of 2w81 by Molmil
Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H
分子名称: COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
著者Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M.
登録日2009-01-08
公開日2009-03-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009
4AYD
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BU of 4ayd by Molmil
Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant
分子名称: 1,2-ETHANEDIOL, COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
著者Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M.
登録日2012-06-20
公開日2012-11-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules
Plos Pathog., 8, 2012
6XZW
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BU of 6xzw by Molmil
Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab.
分子名称: 1,2-ETHANEDIOL, Fab 4B3 (heavy chain), Fab 4B3 (light chain), ...
著者Veggi, D, Cozzi, R.
登録日2020-02-05
公開日2020-10-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.
Plos Pathog., 16, 2020
4AYE
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BU of 4aye by Molmil
Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant
分子名称: 1,2-ETHANEDIOL, COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
著者Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M.
登録日2012-06-20
公開日2012-11-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
7SBZ
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BU of 7sbz by Molmil
JAR5 Fab bound to fHbp v1.1 crystallized in space group I422
分子名称: CADMIUM ION, Factor H-binding protein, JAR5 Heavy Chain, ...
著者Chesterman, C, Malito, E, Bottomley, M.J.
登録日2021-09-26
公開日2022-10-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Active Learning for Rapid Design: An iterative AI approach for accelerated vaccine design that combines active machine learning and high-throughput experimental evaluation
To Be Published
5T5F
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BU of 5t5f by Molmil
Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5
分子名称: Factor H binding protein variant B24, Monoclonal antibody Jar5 heavy chain, Monoclonal antibody Jar5 light chain
著者Malito, E.
登録日2016-08-30
公開日2016-11-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy.
Biochem. J., 473, 2016
5NQX
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BU of 5nqx by Molmil
Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 294.
分子名称: Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein
著者Johnson, S, Jongerius, I, Lea, S.M, Tang, C.M.
登録日2017-04-21
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.66 Å)
主引用文献Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
1YS5
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BU of 1ys5 by Molmil
Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis
分子名称: lipoprotein
著者Cantini, F, Savino, S, Masignani, V, Pizza, M, Scarselli, M, Swennen, E, Romagnoli, G, Veggi, D, Banci, L, Rappuoli, R.
登録日2005-02-07
公開日2006-02-07
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis
J.Biol.Chem., 281, 2006

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件を2024-07-10に公開中

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