7KL5
| Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues: Phe4246 to Val4271 | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Calmodulin-1, ... | 著者 | Fisher, A.J, Ames, J.B, Yu, Q. | 登録日 | 2020-10-29 | 公開日 | 2021-04-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246-Val4271 Reveals a Fifth Calcium Binding Site. Biochemistry, 60, 2021
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6Y4O
| Calmodulin bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain | 分子名称: | CALCIUM ION, Calmodulin-2, Ryanodine receptor 2 | 著者 | Lau, K, Nielsen, L.H, Holt, C, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Van Petegem, F, Overgaard, M.T, Wimmer, R. | 登録日 | 2020-02-21 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.83549082 Å) | 主引用文献 | The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295, 2020
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6Y4P
| Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain | 分子名称: | CALCIUM ION, Calmodulin-1, Ryanodine receptor 2 | 著者 | Lau, K, Nielsen, L.H, Holt, C, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Van Petegem, F, Overgaard, M.T, Wimmer, R. | 登録日 | 2020-02-21 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.13325572 Å) | 主引用文献 | The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295, 2020
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4JKQ
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7U9X
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7U9T
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7UA5
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8UXC
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7UA4
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7UA3
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8UQ2
| Structure of human RyR2-S2808D in the subprimed state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | 著者 | Miotto, M.C, Marks, A.R. | 登録日 | 2023-10-23 | 公開日 | 2023-11-15 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nat Commun, 15, 2024
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7UA1
| Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of ARM210 | 分子名称: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | 著者 | Miotto, M.C, Marks, A.R. | 登録日 | 2022-03-11 | 公開日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Sci Adv, 8, 2022
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8UXG
| Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 | 分子名称: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | 著者 | Miotto, M.C, Marks, A.R. | 登録日 | 2023-11-09 | 公開日 | 2023-11-22 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nat Commun, 15, 2024
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7U9Q
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8UXL
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8UXF
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8UQ3
| Structure of human RyR2-S2808D in the closed state in the presence of ARM210 | 分子名称: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | 著者 | Miotto, M.C, Marks, A.R. | 登録日 | 2023-10-23 | 公開日 | 2023-11-15 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nat Commun, 15, 2024
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8UXI
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7U9Z
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8UXH
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8UXE
| Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 | 分子名称: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | 著者 | Miotto, M.C, Marks, A.R. | 登録日 | 2023-11-09 | 公開日 | 2023-11-22 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nat Commun, 15, 2024
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8UXM
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7UA9
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8UQ4
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7U9R
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