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PDB: 21 件
6AM7
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Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9
分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1
著者Buller, A.R, van Roye, P.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
5IXJ
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BU of 5ixj by Molmil
Tryptophan Synthase beta-subunit from Pyrococcus furiosus with L-threonine non-covalently bound in the active site
分子名称: SODIUM ION, THREONINE, Tryptophan synthase beta chain 1
著者Buller, A.R, Herger, M, Arnold, F.H.
登録日2016-03-23
公開日2016-08-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Synthesis of beta-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase.
J.Am.Chem.Soc., 138, 2016
6AMH
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BU of 6amh by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11 with Ser bound as E(Aex1)
分子名称: SODIUM ION, Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
著者Buller, A.R.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
5VM5
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BU of 5vm5 by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser bound
分子名称: 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, SODIUM ION, Tryptophan synthase beta chain 1, ...
著者Buller, A.R, van Roye, P.
登録日2017-04-26
公開日2017-05-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
5DVZ
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BU of 5dvz by Molmil
Holo TrpB from Pyrococcus furiosus
分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1
著者Buller, A.R, Arnold, F.H.
登録日2015-09-21
公開日2016-02-03
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DW3
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BU of 5dw3 by Molmil
Tryptophan Synthase beta-subunit from Pyrococcus furiosus with product L-tryptophan non-covalently bound in the active site
分子名称: PHOSPHATE ION, SODIUM ION, TRYPTOPHAN, ...
著者Buller, A.R, Arnold, F.H.
登録日2015-09-22
公開日2015-11-11
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
6CUZ
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BU of 6cuz by Molmil
Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate
分子名称: (2E)-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pent-2-enoic acid, PHOSPHATE ION, SODIUM ION, ...
著者Scheele, R.A, Buller, A.R, Boville, C.E, Arnold, F.H.
登録日2018-03-27
公開日2018-09-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues.
Angew. Chem. Int. Ed. Engl., 57, 2018
6CUT
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BU of 6cut by Molmil
Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3S)-isopropylserine bound as the external aldimine
分子名称: (2S,3S)-3-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-methylpentanoic acid (non-preferred name), SODIUM ION, Tryptophan synthase beta chain 1
著者Boville, C.E, Scheele, R.A, Buller, A.R, Arnold, F.H.
登録日2018-03-26
公開日2018-09-26
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues.
Angew. Chem. Int. Ed. Engl., 57, 2018
5T6M
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BU of 5t6m by Molmil
Structure of the tryptophan synthase b-subunit from Pyroccus furiosus with b-methyltryptophan non-covalently bound
分子名称: (betaS)-beta-methyl-L-tryptophan, PHOSPHATE ION, SODIUM ION, ...
著者Buller, A.R, van Roye, P, Arnold, F.H.
登録日2016-09-01
公開日2016-12-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity.
Biochemistry, 55, 2016
6AM8
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BU of 6am8 by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9 with Trp bound as E(Aex2)
分子名称: SODIUM ION, TRYPTOPHAN, Tryptophan synthase beta chain 1, ...
著者Buller, A.R, van Roye, P.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
6AMC
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BU of 6amc by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11
分子名称: SODIUM ION, Tryptophan synthase beta chain 1
著者Buller, A.R, Herger, M.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
6AMI
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BU of 6ami by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11 with Trp non-covalently bound
分子名称: SODIUM ION, TRYPTOPHAN, Tryptophan synthase beta chain 1
著者Buller, A.R.
登録日2017-08-09
公開日2018-05-16
最終更新日2022-03-23
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
5DW0
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BU of 5dw0 by Molmil
TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine
分子名称: SODIUM ION, Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
著者Buller, A.R, Arnold, F.H.
登録日2015-09-22
公開日2015-11-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
6AM9
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BU of 6am9 by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser-bound in a predominantly closed state.
分子名称: 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, SODIUM ION, Tryptophan synthase beta chain 1, ...
著者Buller, A.R, van Roye, P.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
7RNQ
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BU of 7rnq by Molmil
Holo structure of engineered TrpB, 2B9-H275E, from Pyrococcus furiosus in the extended-open conformation
分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1
著者Higgins, P.M, Buller, A.R.
登録日2021-07-29
公開日2022-08-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis.
Nat Commun, 13, 2022
1V8Z
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BU of 1v8z by Molmil
X-ray crystal structure of the Tryptophan Synthase b2 Subunit from Hyperthermophile, Pyrococcus furiosus
分子名称: PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, Tryptophan synthase beta chain 1
著者Hioki, Y, Ogasahara, K, Lee, S.J, Ma, J, Ishida, M, Yamagata, Y, Matsuura, Y, Ota, M, Kuramitsu, S, Yutani, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-01-15
公開日2005-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献The crystal structure of the tryptophan synthase beta subunit from the hyperthermophile Pyrococcus furiosus. Investigation of stabilization factors
Eur.J.Biochem., 271, 2004
7RNP
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BU of 7rnp by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9_H275E with 4-Cl-Trp non-covalently bound
分子名称: 4-chloro-L-tryptophan, SODIUM ION, Tryptophan synthase beta chain 1
著者Higgins, P.M, Buller, A.R.
登録日2021-07-29
公開日2022-08-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis.
Nat Commun, 13, 2022
6CUV
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BU of 6cuv by Molmil
Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6
分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1
著者Scheele, R.A, Buller, A.R, Boville, C.E, Arnold, F.H.
登録日2018-03-26
公開日2018-09-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues.
Angew. Chem. Int. Ed. Engl., 57, 2018
7ROF
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BU of 7rof by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9-H275E with L-Trp non-covalently bound
分子名称: SODIUM ION, TRYPTOPHAN, Tryptophan synthase beta chain 1
著者Higgins, P.M, Buller, A.R.
登録日2021-07-30
公開日2022-08-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis.
Nat Commun, 13, 2022
5E0K
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BU of 5e0k by Molmil
X-ray crystal structure of tryptophan synthase complex from Pyrococcus furiosus at 2.76 A
分子名称: PHOSPHATE ION, Tryptophan synthase alpha chain, Tryptophan synthase beta chain 1
著者Buller, A.R, Murciano-Calles, J, Arnold, F.H.
登録日2015-09-29
公開日2015-11-11
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
1WDW
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BU of 1wdw by Molmil
Structural basis of mutual activation of the tryptophan synthase a2b2 complex from a hyperthermophile, Pyrococcus furiosus
分子名称: PYRIDOXAL-5'-PHOSPHATE, Tryptophan synthase alpha chain, Tryptophan synthase beta chain 1
著者Lee, S.J, Ogasahara, K, Ma, J, Nishio, K, Ishida, M, Yamagata, Y, Tsukihara, T, Yutani, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-05-19
公開日2005-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Conformational Changes in the Tryptophan Synthase from a Hyperthermophile upon alpha(2)beta(2) Complex Formation: Crystal Structure of the Complex
Biochemistry, 44, 2005

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