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PDB: 28 件
4JJ7
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BU of 4jj7 by Molmil
Caspase-3 specific unnatural amino acid-based peptides
分子名称: Caspase inhibitor, Caspase-8, DITHIANE DIOL
著者Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W.
登録日2013-03-07
公開日2013-06-12
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.178 Å)
主引用文献Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids.
Acs Chem.Biol., 8, 2013
1QTN
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BU of 1qtn by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TETRAPEPTIDE INHIBITOR ACE-IETD-ALDEHYDE
分子名称: ACETYL-ILE-GLU-THR-ASP-ALDEHYDE, CASPASE-8, DITHIANE DIOL
著者Watt, W, Watenpaugh, K.D.
登録日1999-06-28
公開日2000-09-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The atomic-resolution structure of human caspase-8, a key activator of apoptosis.
Structure Fold.Des., 7, 1999
7LVM
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BU of 7lvm by Molmil
CASP8 isoform B DED domain
分子名称: Caspase-8
著者Weichert, K, Lu, F, Kodandapani, L, Sauder, J.M.
登録日2021-02-25
公開日2022-03-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4, 2022
6X8H
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BU of 6x8h by Molmil
Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct
分子名称: Ac-DW3-KE, Caspase-8
著者Solania, A, Xu, J.H, Wolan, D.W.
登録日2020-06-01
公開日2021-06-02
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct
To Be Published
7LVJ
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BU of 7lvj by Molmil
CASP8 isoform G DED domain
分子名称: Isoform 9 of Caspase-8
著者Weichert, K, Lu, F, Kodandapani, L, Sauder, J.M.
登録日2021-02-25
公開日2022-03-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4, 2022
4PS1
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BU of 4ps1 by Molmil
Caspase-8 specific unnatural amino acid peptides
分子名称: (BAL)LQ(HYP)(1U8) PEPTIDE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Caspase-8
著者Wolan, D.W, Vickers, C.J, Gonzalez-Paez, G.E.
登録日2014-03-06
公開日2015-01-21
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.731 Å)
主引用文献Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.
Acs Chem.Biol., 9, 2014
3KJN
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BU of 3kjn by Molmil
Caspase 8 bound to a covalent inhibitor
分子名称: (3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Caspase-8
著者Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
登録日2009-11-03
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3KJQ
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Caspase 8 with covalent inhibitor
分子名称: (3S)-3-({[(5S,8R)-2-(3-carboxypropyl)-8-(2-{[(4-chlorophenyl)acetyl]amino}ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid, Caspase-8
著者Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
登録日2009-11-03
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
2Y1L
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BU of 2y1l by Molmil
Caspase-8 in Complex with DARPin-8.4
分子名称: 1,2-ETHANEDIOL, AC-IETD-CHO, CASPASE-8, ...
著者Barandun, J, Schroeder, T, Mittl, P.R.E, Grutter, M.G.
登録日2010-12-08
公開日2011-12-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Caspase-8 in Complex with Darpin-8.4
To be Published
3H11
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BU of 3h11 by Molmil
Zymogen caspase-8:c-FLIPL protease domain complex
分子名称: CASP8 and FADD-like apoptosis regulator, Caspase-8, IETD aldehyde inhibitor
著者Jeffrey, P.D, Yu, J.W, Shi, Y.
登録日2009-04-10
公開日2009-04-28
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mechanism of procaspase-8 activation by c-FLIPL.
Proc.Natl.Acad.Sci.USA, 106, 2009
2C2Z
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BU of 2c2z by Molmil
Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor
分子名称: AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL) -14-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL] -11-[(1R)-1-HYDROXYETHYL]-5-(2-METHYLPROPYL)-3,6,9,12-TETRAOXO -1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN-16-OIC ACID, ...
著者Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A.J, Mikolajczyk, J, Salvesen, G.S, Powers, J.C, Gruetter, M.G.
登録日2005-10-02
公開日2006-09-20
最終更新日2017-02-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
6AGW
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BU of 6agw by Molmil
Pro-domain of Caspase-8
分子名称: Caspase-8 pro-domain
著者Park, H.H.
登録日2018-08-15
公開日2019-06-26
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.093 Å)
主引用文献Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain.
Cell Death Differ., 26, 2019
4PRZ
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BU of 4prz by Molmil
Caspase-8 specific unnatural amino acid peptides
分子名称: (ACE)LET(1U8) PEPTIDE, Caspase-8, DITHIANE DIOL
著者Wolan, D.W, Vickers, C.J, Gonzalez-Paez, G.E.
登録日2014-03-06
公開日2015-01-21
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.123 Å)
主引用文献Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.
Acs Chem.Biol., 9, 2014
4ZBW
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BU of 4zbw by Molmil
Crystal structure of death effector domain of Caspase8 in Homo Sapiens
分子名称: Caspase-8
著者Shen, C, Wang, T, Quan, J.
登録日2015-04-15
公開日2015-07-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the death effector domains of caspase-8
Biochem.Biophys.Res.Commun., 463, 2015
1QDU
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BU of 1qdu by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK
分子名称: CASPASE-8 ALPHA-CHAIN, CASPASE-8 BETA-CHAIN, PHQ-GLU-VAL-ASP-DICHLOROMETHYLKETONE INHIBITOR
著者Blanchard, H, Grutter, M.G.
登録日1999-07-10
公開日2000-07-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
Structure Fold.Des., 7, 1999
6PX9
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BU of 6px9 by Molmil
Crystal structure of procaspase-8 in complex with covalent small molecule inhibitor 63-R
分子名称: Caspase-8, N-{(3R)-1-[4-(morpholin-4-yl)benzene-1-carbonyl]piperidin-3-yl}-N-phenylacetamide
著者Xu, J.H, Wolan, D.W.
登録日2019-07-25
公開日2020-01-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity.
Acs Chem.Biol., 15, 2020
1F9E
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BU of 1f9e by Molmil
CASPASE-8 SPECIFICITY PROBED AT SUBSITE S4: CRYSTAL STRUCTURE OF THE CASPASE-8-Z-DEVD-CHO
分子名称: (PHQ)DEVD, CASPASE-8 ALPHA CHAIN, CASPASE-8 BETA CHAIN
著者Blanchard, H, Donepudi, M, Tschopp, M, Kodandapani, L, Wu, J.C, Grutter, M.G.
登録日2000-07-10
公開日2001-07-10
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
J.Mol.Biol., 302, 2000
1I4E
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BU of 1i4e by Molmil
CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX
分子名称: Caspase-8, Early 35 kDa protein
著者Xu, G, Cirilli, M, Huang, Y, Rich, R.L, Myszka, D.G, Wu, H.
登録日2001-02-20
公開日2001-03-28
最終更新日2013-09-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex.
Nature, 410, 2001
2FUN
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BU of 2fun by Molmil
alternative p35-caspase-8 complex
分子名称: Early 35 kDa protein, caspase-8
著者Lu, M, Min, T, Eliezer, D, Wu, H.
登録日2006-01-27
公開日2006-06-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Native chemical ligation in covalent caspase inhibition by p35.
Chem.Biol., 13, 2006
8YD8
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BU of 8yd8 by Molmil
Structure of FADD/Caspase-8/cFLIP death effector domain assembly
分子名称: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8, FAS-associated death domain protein
著者Lin, S.-C, Yang, C.-Y.
登録日2024-02-19
公開日2024-05-15
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Nat Commun, 15, 2024
5JQE
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BU of 5jqe by Molmil
Crystal structure of caspase8 tDED
分子名称: Sugar ABC transporter substrate-binding protein,Caspase-8 chimera
著者Fu, T, Li, Y, Lu, A, Wu, H.
登録日2016-05-04
公開日2016-10-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.157 Å)
主引用文献Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol. Cell, 64, 2016
5H31
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Structural basis for dimerization of the death effector domains of Caspase-8
分子名称: Caspase-8
著者Shen, C, Pei, J, Guo, X, Quan, J.
登録日2016-10-19
公開日2017-10-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.16953516 Å)
主引用文献Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
8YD7
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BU of 8yd7 by Molmil
Structure of FADD/Caspase-8/cFLIP death effector domain assembly
分子名称: CASP8 and FADD-like apoptosis regulator subunit p12, Caspase-8, FAS-associated death domain protein, ...
著者Lin, S.-C, Yang, C.-Y.
登録日2024-02-19
公開日2024-05-15
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Nat Commun, 15, 2024
5H33
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Structural basis for dimerization of the death effector domains of Caspase-8
分子名称: Caspase-8
著者Shen, C, Pei, J, Guo, X, Quan, J.
登録日2016-10-20
公開日2017-10-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.600138 Å)
主引用文献Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
8YBX
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BU of 8ybx by Molmil
Structure of the FADD/Caspase-8/cFLIP death effector domain assembly
分子名称: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8 subunit p10, FAS-associated death domain protein
著者Lin, S.-C, Yang, C.-Y.
登録日2024-02-16
公開日2024-05-15
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Nat Commun, 15, 2024

 

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