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PDB: 140 件
7P47
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Structure of the E3 ligase Smc5/Nse2 in complex with Ubc9-SUMO thioester mimetic
分子名称: E3 SUMO-protein ligase MMS21, SUMO-conjugating enzyme UBC9, Structural maintenance of chromosomes protein 5, ...
著者Lascorz, J, Varejao, N, Reverter, D.
登録日2021-07-09
公開日2021-11-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.314 Å)
主引用文献Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs.
Nat Commun, 12, 2021
6VW2
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Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils
分子名称: Islet amyloid polypeptide (SUMO-tagged)
著者Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
登録日2020-02-18
公開日2020-06-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.
Nat.Struct.Mol.Biol., 27, 2020
6O8B
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BU of 6o8b by Molmil
Crystal structure of STING CTD in complex with TBK1
分子名称: N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein
著者Li, P, Zhao, B, Du, F.
登録日2019-03-09
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
7SII
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BU of 7sii by Molmil
Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)
分子名称: 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, Stimulator of interferon genes protein, cGAMP
著者Lu, D, Shang, G, Jie, L, Lu, Y, Bai, X.C, Zhang, X.
登録日2021-10-14
公開日2022-02-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Activation of STING by targeting a pocket in the transmembrane domain.
Nature, 604, 2022
8GT6
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human STING With agonist HB3089
分子名称: 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxamide, Stimulator of interferon genes protein
著者Wang, Z, Yu, X.
登録日2022-09-07
公開日2022-12-28
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.
Cell Discov, 8, 2022
8GSZ
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BU of 8gsz by Molmil
Structure of STING SAVI-related mutant V147L
分子名称: Stimulator of interferon genes protein
著者Wang, Z, Yu, X.
登録日2022-09-07
公開日2022-12-28
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.
Cell Discov, 8, 2022
8R1F
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Monomeric E6AP-E6-p53 ternary complex
分子名称: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ...
著者Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H.
登録日2023-11-01
公開日2023-12-06
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.67 Å)
主引用文献Structural insights into viral hijacking of p53 by E6 and E6AP
Biorxiv, 2023
6Q2S
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Cryo-EM structure of RET/GFRa3/ARTN extracellular complex. The 3D refinement was applied with C2 symmetry.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-3, ...
著者Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C.
登録日2019-08-08
公開日2019-10-02
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
8R1G
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Dimeric ternary structure of E6AP-E6-p53
分子名称: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ...
著者Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H.
登録日2023-11-01
公開日2023-12-06
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.99 Å)
主引用文献Structural insights into viral hijacking of p53 by E6 and E6AP
Biorxiv, 2023
8FLK
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BU of 8flk by Molmil
Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
分子名称: 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP
著者Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y.
登録日2022-12-21
公開日2023-11-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Activation of human STING by a molecular glue-like compound.
Nat.Chem.Biol., 20, 2024
6NT5
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BU of 6nt5 by Molmil
Cryo-EM structure of full-length human STING in the apo state
分子名称: Stimulator of interferon protein
著者Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X.
登録日2019-01-28
公開日2019-03-06
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Nature, 567, 2019
8B7F
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BU of 8b7f by Molmil
Nuclease from C. glutamicum
分子名称: Ubiquitin-like protein SMT3,MksG
著者Wehenkel, A, Ben Assaya, M, Haouz, A.
登録日2022-09-29
公開日2023-03-29
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (4.6 Å)
主引用文献The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.
Nucleic Acids Res., 51, 2023
7ZHS
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BU of 7zhs by Molmil
3D reconstruction of the cylindrical assembly of DnaJA2 delta G/F by imposing D5 symmetry
分子名称: Ubiquitin-like protein SMT3,DnaJ homolog subfamily A member 2, ZINC ION
著者Cuellar, J, Velasco-Carneros, L, Santiago, C, Martin-Benito, J, Valpuesta, J, Muga, A.
登録日2022-04-07
公開日2023-07-26
最終更新日2024-01-24
実験手法ELECTRON MICROSCOPY (6.9 Å)
主引用文献The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70.
Nat Commun, 14, 2023
7O2W
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BU of 7o2w by Molmil
Structure of the C9orf72-SMCR8 complex
分子名称: Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein, Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72
著者Noerpel, J, Cavadini, S, Schenk, A.D, Graff-Meyer, A, Chao, J, Bhaskar, V.
登録日2021-03-31
公開日2021-07-21
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY
主引用文献Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture.
Plos Biol., 19, 2021
1L2N
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BU of 1l2n by Molmil
Smt3 Solution Structure
分子名称: Ubiquitin-like protein SMT3
著者Sheng, W, Liao, X.
登録日2002-02-22
公開日2002-03-06
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions.
Protein Sci., 11, 2002

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件を2024-08-07に公開中

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