6X8O
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![BU of 6x8o by Molmil](/molmil-images/mine/6x8o) | BimBH3 peptide tetramer | 分子名称: | Bcl-2-like protein 11, THIOCYANATE ION | 著者 | Robin, A.Y, Westphal, D, Uson, I, Czabotar, P.E. | 登録日 | 2020-06-01 | 公開日 | 2020-09-09 | 最終更新日 | 2021-02-17 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association. Structure, 29, 2021
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8T5E
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![BU of 8t5e by Molmil](/molmil-images/mine/8t5e) | De novo design of high-affinity protein binders to bioactive helical peptides | 分子名称: | Bcl-2-like protein 11, Bim_fulldiff | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | 登録日 | 2023-06-13 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
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4D2M
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![BU of 4d2m by Molmil](/molmil-images/mine/4d2m) | Vaccinia Virus F1L bound to Bim BH3 | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, BCL-2-LIKE PROTEIN 11, CHLORIDE ION, ... | 著者 | Kvansakul, M, Colman, P.M. | 登録日 | 2014-05-12 | 公開日 | 2014-06-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L. J.Virol., 88, 2014
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4UF3
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![BU of 4uf3 by Molmil](/molmil-images/mine/4uf3) | |
6TQQ
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![BU of 6tqq by Molmil](/molmil-images/mine/6tqq) | |
5WOS
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2YQ7
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![BU of 2yq7 by Molmil](/molmil-images/mine/2yq7) | Structure of Bcl-xL bound to BimLOCK | 分子名称: | BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL | 著者 | Smith, B.J, Czabotar, P.E. | 登録日 | 2012-11-06 | 公開日 | 2012-11-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
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2NL9
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![BU of 2nl9 by Molmil](/molmil-images/mine/2nl9) | Crystal structure of the Mcl-1:Bim BH3 complex | 分子名称: | Bcl-2-like protein 11, CHLORIDE ION, FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, ... | 著者 | Czabotar, P.E, Colman, P.M. | 登録日 | 2006-10-19 | 公開日 | 2007-03-27 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc.Natl.Acad.Sci.USA, 104, 2007
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1PQ1
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![BU of 1pq1 by Molmil](/molmil-images/mine/1pq1) | Crystal structure of Bcl-xl/Bim | 分子名称: | Apoptosis regulator Bcl-X, BCL2-like protein 11 | 著者 | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | 登録日 | 2003-06-17 | 公開日 | 2003-09-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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2K7W
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![BU of 2k7w by Molmil](/molmil-images/mine/2k7w) | BAX Activation is Initiated at a Novel Interaction Site | 分子名称: | Apoptosis regulator BAX, Bcl-2-like protein 11 | 著者 | Gavathiotis, E, Suzuki, M, Davis, M.L, Pitter, K, Bird, G.H, Katz, S.G, Tu, H.C, Kim, H, Cheng, E.H, Tjandra, N, Walensky, L.D. | 登録日 | 2008-08-27 | 公開日 | 2008-10-21 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | BAX activation is initiated at a novel interaction site. Nature, 455, 2008
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6QFI
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![BU of 6qfi by Molmil](/molmil-images/mine/6qfi) | Structure of human Mcl-1 in complex with BIM BH3 peptide | 分子名称: | Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | 著者 | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | 登録日 | 2019-01-10 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4, 2019
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4QVF
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3FDL
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![BU of 3fdl by Molmil](/molmil-images/mine/3fdl) | Bim BH3 peptide in complex with Bcl-xL | 分子名称: | Apoptosis regulator Bcl-X, Bcl-2-like protein 11 | 著者 | Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M. | 登録日 | 2008-11-26 | 公開日 | 2009-03-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L) Angew.Chem.Int.Ed.Engl., 48, 2009
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6RJP
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![BU of 6rjp by Molmil](/molmil-images/mine/6rjp) | Bfl-1 in complex with alpha helical peptide | 分子名称: | Bcl-2-like protein 11, Bcl-2-related protein A1 | 著者 | Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M. | 登録日 | 2019-04-29 | 公開日 | 2019-10-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists. Chem.Biol.Drug Des., 95, 2020
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2YQ6
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![BU of 2yq6 by Molmil](/molmil-images/mine/2yq6) | Structure of Bcl-xL bound to BimSAHB | 分子名称: | BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL | 著者 | Smith, B.J, Czabotar, P.E. | 登録日 | 2012-11-06 | 公開日 | 2012-11-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | 主引用文献 | Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
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3D7V
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![BU of 3d7v by Molmil](/molmil-images/mine/3d7v) | Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand | 分子名称: | Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | 著者 | Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D. | 登録日 | 2008-05-22 | 公開日 | 2008-06-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J.Cell Biol., 180, 2008
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6UA3
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6UAB
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6VBX
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![BU of 6vbx by Molmil](/molmil-images/mine/6vbx) | Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide | 著者 | Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z. | 登録日 | 2019-12-19 | 公開日 | 2020-12-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1. J.Med.Chem., 64, 2021
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5AGX
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![BU of 5agx by Molmil](/molmil-images/mine/5agx) | Bcl-2 alpha beta-1 LINEAR complex | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11 | 著者 | Smith, B.J, F Lee, E, Checco, J.W, Gellman, S.H, Fairlie, W.D. | 登録日 | 2015-02-04 | 公開日 | 2015-09-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells J.Am.Chem.Soc., 137, 2015
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2VM6
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![BU of 2vm6 by Molmil](/molmil-images/mine/2vm6) | Human Bcl2-A1 in complex with Bim-BH3 peptide | 分子名称: | BCL-2-LIKE PROTEIN 11, BCL-2-RELATED PROTEIN A1, SULFATE ION | 著者 | Herman, M.D, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC) | 登録日 | 2008-01-23 | 公開日 | 2008-02-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Completing the Family Portrait of the Anti- Apoptotic Bcl-2 Proteins: Crystal Structure of Human Bfl-1 in Complex with Bim. FEBS Lett., 582, 2008
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2WH6
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![BU of 2wh6 by Molmil](/molmil-images/mine/2wh6) | Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain | 分子名称: | BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ... | 著者 | Kvansakul, M, Huang, D.C.S, Colman, P.M. | 登録日 | 2009-05-01 | 公開日 | 2010-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1. PLoS Pathog., 6, 2010
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5AGW
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![BU of 5agw by Molmil](/molmil-images/mine/5agw) | Bcl-2 alpha beta-1 complex | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11 | 著者 | Smith, B.J, F Lee, E, Checco, J.W, Gellman, S.H, Fairlie, W.D. | 登録日 | 2015-02-04 | 公開日 | 2015-09-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.695 Å) | 主引用文献 | Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells J.Am.Chem.Soc., 137, 2015
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4A1W
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![BU of 4a1w by Molmil](/molmil-images/mine/4a1w) | Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1 | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | 登録日 | 2011-09-20 | 公開日 | 2011-12-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. J.Am.Chem.Soc., 134, 2012
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4A1U
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![BU of 4a1u by Molmil](/molmil-images/mine/4a1u) | Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ... | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | 登録日 | 2011-09-20 | 公開日 | 2011-12-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. J.Am.Chem.Soc., 134, 2012
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