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PDB: 176 件
1FLZ
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URACIL DNA GLYCOSYLASE WITH UAAP
分子名称: URACIL, URACIL-DNA GLYCOSYLASE
著者Werner, R.M, Jiang, Y.L, Gordley, R.G, Jagadeesh, G.J, Ladner, J.E, Xiao, G, Tordova, M, Gilliland, G.L, Stivers, J.T.
登録日2000-08-15
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase.
Biochemistry, 39, 2000
5FF8
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TDG enzyme-product complex
分子名称: DNA, G/T mismatch-specific thymine DNA glycosylase
著者Pozharski, E, Malik, S.S, Drohat, A.C.
登録日2015-12-18
公開日2016-09-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues.
Nucleic Acids Res., 44, 2016
4SKN
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A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA
分子名称: DNA (5'-D(*AP*AP*AP*GP*CP*CP*GP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*(D1P)P*GP*GP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE), ...
著者Slupphaug, G, Mol, C.D, Kavli, B, Arvai, A.S, Krokan, H.E, Tainer, J.A.
登録日1999-02-20
公開日1999-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature, 384, 1996
2RBA
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BU of 2rba by Molmil
Structure of Human Thymine DNA Glycosylase Bound to Abasic and Undamaged DNA
分子名称: DNA (5'-D(*DCP*DAP*DGP*DCP*DTP*DCP*DTP*DGP*DTP*DAP*DCP*DGP*DTP*DGP*DAP*DGP*DCP*DAP*DGP*DTP*DGP*DGP*DA)-3'), DNA (5'-D(*DCP*DCP*DAP*DCP*DTP*DGP*DCP*DTP*DCP*DAP*(3DR)P*DGP*DTP*DAP*DCP*DAP*DGP*DAP*DGP*DCP*DTP*DGP*DT)-3'), G/T mismatch-specific thymine DNA glycosylase
著者Maiti, A, Pozharski, E, Drohat, A.C.
登録日2007-09-18
公開日2008-06-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5JXY
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Enzyme-substrate complex of TDG catalytic domain bound to a G/U analog
分子名称: DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
著者Pidugu, L.S, Pozharski, E, Malik, S.S, Drohat, A.C.
登録日2016-05-13
公開日2016-09-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues.
Nucleic Acids Res., 44, 2016
6VBA
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BU of 6vba by Molmil
Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA)
分子名称: 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid), Uracil-DNA glycosylase
著者Moiani, D, Arvai, A.S, Tainer, J.A.
登録日2019-12-18
公開日2021-03-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Prog.Biophys.Mol.Biol., 163, 2021
3IKB
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BU of 3ikb by Molmil
The structure of a conserved protein from Streptococcus mutans UA159.
分子名称: CITRATE ANION, uncharacterized conserved protein
著者Tan, K, Hatzos, C, Buck, K, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2009-08-05
公開日2009-08-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献The structure of a conserved protein from Streptococcus mutans UA159.
To be Published
1YUO
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BU of 1yuo by Molmil
Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG)from atlantic cod (Gadus morhua)
分子名称: Uracil-DNA glycosylase
著者Moe, E, Leiros, I, Riise, E.K, Olufsen, M, Lanes, O, Smalas, A.O, Willassen, N.P.
登録日2005-02-14
公開日2005-03-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua)
J.Mol.Biol., 343, 2004
4FNC
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Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)
分子名称: 5-HYDROXYMETHYL URACIL, DNA (28-MER), DNA (29-MER), ...
著者Hashimoto, H, Hong, S, Bhagwat, A.S, Zhang, X, Cheng, X.
登録日2012-06-19
公開日2012-09-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.493 Å)
主引用文献Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.
Nucleic Acids Res., 40, 2012
4EUG
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Crystallographic and Enzymatic Studies of an Active Site Variant H187Q of Escherichia Coli Uracil DNA Glycosylase: Crystal Structures of Mutant H187Q and its Uracil Complex
分子名称: PROTEIN (GLYCOSYLASE)
著者Xiao, G, Tordova, M, Drohat, A.C, Jagadeesh, J, Stivers, J.T, Gilliland, G.L.
登録日1998-12-27
公開日1999-07-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.
Biochemistry, 38, 1999
5T2W
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BU of 5t2w by Molmil
Structure of thymine DNA glycosylase bound to substrate analog 2'-F-5-formyl-dC
分子名称: DNA (27-MER), DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
著者Pidugu, L.S, Pozharski, E, Drohat, A.C.
登録日2016-08-24
公開日2016-11-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.
Biochemistry, 55, 2016
3TKB
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BU of 3tkb by Molmil
crystal structure of human uracil-DNA glycosylase D183G/K302R mutant
分子名称: IMIDAZOLE, Uracil-DNA glycosylase
著者Assefa, N.G, Niiranen, L, Willassen, N.P, Smalas, A.O, Moe, E.
登録日2011-08-26
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG.
Comp.Biochem.Physiol. B: Biochem.Mol.Biol., 161, 2012
2SSP
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BU of 2ssp by Molmil
LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA
分子名称: DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*TP*(AAB)P*AP*TP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE)
著者Parikh, S.S, Mol, C.D, Slupphaug, G, Bharati, S, Krokan, H.E, Tainer, J.A.
登録日1999-04-28
公開日1999-05-06
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
EMBO J., 17, 1998
3A7N
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BU of 3a7n by Molmil
Crystal structure of uracil-DNA glycosylase from Mycobacterium tuberculosis
分子名称: CITRATE ANION, Uracil-DNA glycosylase
著者Kaushal, P.S, Talawar, R.K, Varshney, U, Vijayan, M.
登録日2009-09-29
公開日2010-08-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands
Acta Crystallogr.,Sect.F, 66, 2010
5CYS
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BU of 5cys by Molmil
Structure of the enzyme-product complex resulting from TDG action on a GcaC mismatch
分子名称: ACETIC ACID, DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
著者Pozharski, E, Malik, S.S, Drohat, A.C.
登録日2015-07-30
公開日2015-09-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Characterizing the enzyme-product complexes of thymine DNA glycosylase using crystallography and NMR
Nucleic Acids Res., 2015
5EUG
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BU of 5eug by Molmil
CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX
分子名称: PROTEIN (GLYCOSYLASE), URACIL
著者Xiao, G, Tordova, M, Drohat, A.C, Jagadeesh, J, Stivers, J.T, Gilliland, G.L.
登録日1998-12-27
公開日1999-07-23
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
2OXM
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BU of 2oxm by Molmil
Crystal structure of a UNG2/modified DNA complex that represent a stabilized short-lived extrahelical state in ezymatic DNA base flipping
分子名称: DNA (5'-D(*AP*AP*AP*GP*AP*TP*(4MF)P*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*AP*TP*CP*TP*T)-3'), Uracil-DNA glycosylase
著者Bianchet, M.A, Krosky, D.J, Stivers, J.T, Amzel, L.M.
登録日2007-02-20
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
Nature, 449, 2007
2OYT
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BU of 2oyt by Molmil
Crystal Structure of UNG2/DNA(TM)
分子名称: DNA strand1, DNA strand2, Uracil-DNA glycosylase
著者Bianchet, M.A, Krosky, D.J, Stivers, J.T, Amzel, L.M.
登録日2007-02-22
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
Nature, 449, 2007
6AJQ
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BU of 6ajq by Molmil
E52Q mutant form of Uracil DNA glycosylase X from Mycobacterium smegmatis.
分子名称: IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein
著者Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J.
登録日2018-08-28
公開日2019-05-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.342 Å)
主引用文献Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
6AJP
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Complex form of Uracil DNA glycosylase X and deoxyuridine monophosphate.
分子名称: 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein
著者Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J.
登録日2018-08-28
公開日2019-05-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.334 Å)
主引用文献Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
6AJS
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BU of 6ajs by Molmil
H109S mutant form of Uracil DNA glycosylase X.
分子名称: IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein
著者Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J.
登録日2018-08-28
公開日2019-05-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.632 Å)
主引用文献Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
1MUG
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BU of 1mug by Molmil
G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI
分子名称: PROTEIN (G:T/U SPECIFIC DNA GLYCOSYLASE), SULFATE ION
著者Barrett, T.E, Savva, R, Panayotou, G, Brown, T, Barlow, T, Jiricny, J, Pearl, L.H.
登録日1998-07-10
公開日1998-07-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.
Cell(Cambridge,Mass.), 92, 1998
3TR7
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BU of 3tr7 by Molmil
Structure of a uracil-DNA glycosylase (ung) from Coxiella burnetii
分子名称: Uracil-DNA glycosylase
著者Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J.
登録日2011-09-09
公開日2011-09-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.1958 Å)
主引用文献Structural genomics for drug design against the pathogen Coxiella burnetii.
Proteins, 83, 2015
1MWJ
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Crystal Structure of a MUG-DNA pseudo substrate complex
分子名称: 5'-D(*CP*GP*CP*GP*A*GP*(DU)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase
著者Barrett, T.E, Scharer, O, Savva, R, Brown, T, Jiricny, J, Verdine, G.L, Pearl, L.H.
登録日2002-09-30
公開日2002-10-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystal Structure of a thwarted mismatch glycosylase DNA repair complex
Embo J., 18, 1999
1MTL
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Non-productive MUG-DNA complex
分子名称: 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3', G/U mismatch-specific DNA glycosylase
著者Barrett, T.E, Savva, R, Barlow, T, Brown, T, Jiricny, J, Pearl, L.H.
登録日2002-09-21
公開日2002-09-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct.
Nat.Struct.Biol., 5, 1998

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