2RBA
Structure of Human Thymine DNA Glycosylase Bound to Abasic and Undamaged DNA
Summary for 2RBA
| Entry DOI | 10.2210/pdb2rba/pdb |
| Descriptor | DNA (5'-D(*DCP*DAP*DGP*DCP*DTP*DCP*DTP*DGP*DTP*DAP*DCP*DGP*DTP*DGP*DAP*DGP*DCP*DAP*DGP*DTP*DGP*DGP*DA)-3'), DNA (5'-D(*DCP*DCP*DAP*DCP*DTP*DGP*DCP*DTP*DCP*DAP*(3DR)P*DGP*DTP*DAP*DCP*DAP*DGP*DAP*DGP*DCP*DTP*DGP*DT)-3'), G/T mismatch-specific thymine DNA glycosylase (3 entities in total) |
| Functional Keywords | protein-dna complex, dna damage, dna repair, glycosidase, hydrolase, nucleus, hydrolase-dna complex, hydrolase/dna |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: Q13569 |
| Total number of polymer chains | 4 |
| Total formula weight | 60155.38 |
| Authors | Maiti, A.,Pozharski, E.,Drohat, A.C. (deposition date: 2007-09-18, release date: 2008-06-17, Last modification date: 2023-08-30) |
| Primary citation | Maiti, A.,Morgan, M.T.,Pozharski, E.,Drohat, A.C. Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition. Proc.Natl.Acad.Sci.Usa, 105:8890-8895, 2008 Cited by PubMed: 18587051DOI: 10.1073/pnas.0711061105 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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