2SSP

LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA

Summary for 2SSP

• Entry DOI: 10.2210/pdb2ssp/pdb
• Descriptor: DNA (5'-D(*CP*TP*GP*TP*(AAB)P*AP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*AP*G)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE), ... (4 entities in total)
• Functional Keywords: dna glycosylase, dna base excision repair, uracil, dna, protein/dna, abasic site, protein-dna complex
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Mitochondrion. Isoform 2: Nucleus: P13051
• Total number of polymer chains: 3
• Total formula weight: 31794.21

Authors

Parikh, S.S.,Mol, C.D.,Slupphaug, G.,Bharati, S.,Krokan, H.E.,Tainer, J.A. (deposition date: 1999-04-28, release date: 1999-05-06, Last modification date: 2023-08-02)

• Primary citation: Parikh, S.S.,Mol, C.D.,Slupphaug, G.,Bharati, S.,Krokan, H.E.,Tainer, J.A.; Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.; EMBO J., 17:5214-5226, 1998; PubMed: 9724657; DOI: 10.1093/emboj/17.17.5214

Experimental method

X-RAY DIFFRACTION (2.25 Å)