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PDB: 30 件
7PDJ
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R12E vFLIP mutant
分子名称: FLICE inhibitory protein
著者Barrett, T.E.
登録日2021-08-05
公開日2022-05-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Mechanistic insights into the activation of the IKK kinase complex by the Kaposi's sarcoma herpes virus oncoprotein vFLIP.
J.Biol.Chem., 298, 2022
1N3K
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Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15)
分子名称: Astrocytic phosphoprotein PEA-15
著者Hill, J.M, Vaidyanathan, H, Ramos, J.W, Ginsberg, M.H, Werner, M.H.
登録日2002-10-28
公開日2003-01-14
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain
Embo J., 21, 2002
2LS7
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High Definition Solution Structure of PED/PEA-15 Death Effector Domain
分子名称: Astrocytic phosphoprotein PEA-15
著者Twomey, E.C, Wei, Y.
登録日2012-04-20
公開日2012-08-08
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions.
Biochem.Biophys.Res.Commun., 424, 2012
6M6O
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NMR SOLUTION STRUCTURE OF A C-FLIPs
分子名称: CASP8 and FADD-like apoptosis regulator
著者Bai, Z.Q, Hu, K.F.
登録日2020-03-16
公開日2021-03-17
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution structure of c-FLIP death effector domains.
Biochem.Biophys.Res.Commun., 617, 2022
4ZBW
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Crystal structure of death effector domain of Caspase8 in Homo Sapiens
分子名称: Caspase-8
著者Shen, C, Wang, T, Quan, J.
登録日2015-04-15
公開日2015-07-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the death effector domains of caspase-8
Biochem.Biophys.Res.Commun., 463, 2015
3CL3
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Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome
分子名称: NF-kappa-B essential modulator, ORF K13
著者Bagneris, C, Ageichik, A.V, Cronin, N, Boshoff, C, Waksman, G, Barrett, T.
登録日2008-03-18
公開日2008-06-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Mol.Cell, 30, 2008
7DEE
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Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8
分子名称: C8-H1a, CASP8 and FADD-like apoptosis regulator
著者Bai, Z.Q, Hu, K.F.
登録日2020-11-03
公開日2021-11-03
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Backbone and side-chain chemical shift assignments of a cellular FLICE-inhibitory protein (c-FLIPS)
Biomol NMR Assign, 14, 2020
6AGW
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Pro-domain of Caspase-8
分子名称: Caspase-8 pro-domain
著者Park, H.H.
登録日2018-08-15
公開日2019-06-26
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.093 Å)
主引用文献Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain.
Cell Death Differ., 26, 2019
6P6B
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CS-Rosetta Model of PEA-15 Death Effector Domain
分子名称: Astrocytic phosphoprotein PEA-15
著者Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S.
登録日2019-06-03
公開日2019-07-24
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions.
Int J Mol Sci, 20, 2019
6P6C
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CS-Rosetta Model of PEA-15 Death Effector Domain in the Complex with ERK2
分子名称: Astrocytic phosphoprotein PEA-15
著者Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S.
登録日2019-06-03
公開日2019-07-24
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions.
Int J Mol Sci, 20, 2019
1A1Z
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FADD DEATH EFFECTOR DOMAIN, F25G MUTANT, NMR MINIMIZED AVERAGE STRUCTURE
分子名称: FADD PROTEIN
著者Eberstadt, M, Huang, B, Chen, Z, Meadows, R.P, Ng, C, Fesik, S.W.
登録日1997-12-18
公開日1998-12-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Nature, 392, 1998
1A1W
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FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE
分子名称: FADD PROTEIN
著者Eberstadt, M, Huang, B, Chen, Z, Meadows, R.P, Ng, C, Fesik, S.W.
登録日1997-12-18
公開日1998-12-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Nature, 392, 1998
5H31
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Structural basis for dimerization of the death effector domains of Caspase-8
分子名称: Caspase-8
著者Shen, C, Pei, J, Guo, X, Quan, J.
登録日2016-10-19
公開日2017-10-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.16953516 Å)
主引用文献Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
5H33
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Structural basis for dimerization of the death effector domains of Caspase-8
分子名称: Caspase-8
著者Shen, C, Pei, J, Guo, X, Quan, J.
登録日2016-10-20
公開日2017-10-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.600138 Å)
主引用文献Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
7LVJ
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CASP8 isoform G DED domain
分子名称: Isoform 9 of Caspase-8
著者Weichert, K, Lu, F, Kodandapani, L, Sauder, J.M.
登録日2021-02-25
公開日2022-03-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4, 2022
7LVM
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CASP8 isoform B DED domain
分子名称: Caspase-8
著者Weichert, K, Lu, F, Kodandapani, L, Sauder, J.M.
登録日2021-02-25
公開日2022-03-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4, 2022
7LXC
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Structure and Interactions of DED1 of human cFLIP
分子名称: DED1ch
著者Panaitiu, A.E, Basiashvili, T, Mierke, D.F, Pellegrini, M.
登録日2021-03-03
公開日2021-12-01
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献An engineered construct of cFLIP provides insight into DED1 structure and interactions.
Structure, 30, 2022
5L08
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Cryo-EM structure of Casp-8 tDED filament
分子名称: Caspase-8
著者Fu, T.M, Li, Y, Lu, A, Wu, H.
登録日2016-07-26
公開日2016-11-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol.Cell, 64, 2016
2BBZ
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Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition
分子名称: Viral CASP8 and FADD-like apoptosis regulator
著者Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H.
登録日2005-10-18
公開日2006-02-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
2BBR
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Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition
分子名称: AZIDE ION, Viral CASP8 and FADD-like apoptosis regulator
著者Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H.
登録日2005-10-17
公開日2006-02-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
2F1S
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Crystal Structure of a Viral FLIP MC159
分子名称: Viral CASP8 and FADD-like apoptosis regulator
著者Li, F.-Y, Jeffrey, P.D, Yu, J.W, Shi, Y.
登録日2005-11-15
公開日2005-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal Structure of a Viral FLIP: INSIGHTS INTO FLIP-MEDIATED INHIBITION OF DEATH RECEPTOR SIGNALING.
J.Biol.Chem., 281, 2006
5JQE
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Crystal structure of caspase8 tDED
分子名称: Sugar ABC transporter substrate-binding protein,Caspase-8 chimera
著者Fu, T, Li, Y, Lu, A, Wu, H.
登録日2016-05-04
公開日2016-10-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.157 Å)
主引用文献Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol. Cell, 64, 2016
5LDE
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Crystal structure of a vFLIP-IKKgamma stapled peptide dimer
分子名称: Immunoglobulin G-binding protein G,Viral FLICE protein, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, ...
著者Barrett, T.
登録日2016-06-24
公開日2017-10-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.38 Å)
主引用文献IKK gamma-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection.
J. Virol., 91, 2017
2GF5
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Structure of intact FADD (MORT1)
分子名称: FADD protein
著者Carrington, P.E, Sandu, C, Wei, Y, Hill, J.M, Morisawa, G, Huang, T, Gavathiotis, E, Wei, Y, Werner, M.H.
登録日2006-03-21
公開日2006-06-27
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献The Structure of FADD and Its Mode of Interaction with Procaspase-8
Mol.Cell, 22, 2006
8YBX
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Structure of the FADD/Caspase-8/cFLIP death effector domain assembly
分子名称: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8 subunit p10, FAS-associated death domain protein
著者Lin, S.-C, Yang, C.-Y.
登録日2024-02-16
公開日2024-05-15
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Nat Commun, 15, 2024

 

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