5L08

Cryo-EM structure of Casp-8 tDED filament

Summary for 5L08

• Entry DOI: 10.2210/pdb5l08/pdb
• EMDB information: 8300
• Descriptor: Caspase-8 (1 entity in total)
• Functional Keywords: casp-8, filament, ded, death domain, apoptosis
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q14790
• Total number of polymer chains: 9
• Total formula weight: 198004.37

Authors

Fu, T.M.,Li, Y.,Lu, A.,Wu, H. (deposition date: 2016-07-26, release date: 2016-11-02, Last modification date: 2024-03-06)

• Primary citation: Fu, T.M.,Li, Y.,Lu, A.,Li, Z.,Vajjhala, P.R.,Cruz, A.C.,Srivastava, D.B.,DiMaio, F.,Penczek, P.A.,Siegel, R.M.,Stacey, K.J.,Egelman, E.H.,Wu, H.; Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.; Mol.Cell, 64:236-250, 2016; PubMed: 27746017; DOI: 10.1016/j.molcel.2016.09.009

Experimental method

ELECTRON MICROSCOPY (4.6 Å)