5L08

Cryo-EM structure of Casp-8 tDED filament

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0042981	biological_process	regulation of apoptotic process
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0042981	biological_process	regulation of apoptotic process
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0042981	biological_process	regulation of apoptotic process
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0006915	biological_process	apoptotic process
E	0042981	biological_process	regulation of apoptotic process
F	0004197	molecular_function	cysteine-type endopeptidase activity
F	0006508	biological_process	proteolysis
F	0006915	biological_process	apoptotic process
F	0042981	biological_process	regulation of apoptotic process
G	0004197	molecular_function	cysteine-type endopeptidase activity
G	0006508	biological_process	proteolysis
G	0006915	biological_process	apoptotic process
G	0042981	biological_process	regulation of apoptotic process
H	0004197	molecular_function	cysteine-type endopeptidase activity
H	0006508	biological_process	proteolysis
H	0006915	biological_process	apoptotic process
H	0042981	biological_process	regulation of apoptotic process
I	0004197	molecular_function	cysteine-type endopeptidase activity
I	0006508	biological_process	proteolysis
I	0006915	biological_process	apoptotic process
I	0042981	biological_process	regulation of apoptotic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	SITE: Cleavage; by autocatalytic cleavage => ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9184224

Chain	Residue	Details
A	LEU157
B	LEU157
C	LEU157
D	LEU157
E	LEU157
F	LEU157
G	LEU157
H	LEU157
I	LEU157

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O89110

Chain	Residue	Details
A	SER129
E	LEU152
F	SER129
F	LEU152
G	SER129
G	LEU152
H	SER129
H	LEU152
I	SER129
I	LEU152
A	LEU152
B	SER129
B	LEU152
C	SER129
C	LEU152
D	SER129
D	LEU152
E	SER129

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O89110

Chain	Residue	Details
A	ALA165
B	ALA165
C	ALA165
D	ALA165
E	ALA165
F	ALA165
G	ALA165
H	ALA165
I	ALA165

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA3
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA4
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA5
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA6
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA7
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA8
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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site_id	MCSA9
Number of Residues
Details	M-CSA 818

Chain

Residue

Details

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