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PDB: 48 件
4GDX
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BU of 4gdx by Molmil
Crystal Structure of Human Gamma-Glutamyl Transpeptidase--Glutamate complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTAMIC ACID, ...
著者West, M.B, Chen, Y, Wickham, S, Heroux, A, Cahill, K, Hanigan, M.H, Mooers, B.H.M.
登録日2012-08-01
公開日2013-09-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Novel Insights into Eukaryotic gamma-Glutamyltranspeptidase 1 from the Crystal Structure of the Glutamate-bound Human Enzyme.
J.Biol.Chem., 288, 2013
6XPB
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BU of 6xpb by Molmil
Structure of human GGT1 in complex with 2-amino-4-(((1-((carboxymethyl)amino)-1-oxobutan-2-yl)oxy)(phenoxy)phosphoryl)butanoic acid (ACPB) molecule
分子名称: 2,2-diamino-4-[(S)-({(2S)-1-[(carboxymethyl)amino]-1-oxobutan-2-yl}oxy)(hydroxy)phosphanyl]butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Terzyan, S.S, Hanigan, M.H.
登録日2020-07-08
公開日2020-11-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.
J.Biol.Chem., 296, 2020
2I3O
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BU of 2i3o by Molmil
Crystal structure of gamma-glutamyl transferase related protein from Thermoplasma acidophilum
分子名称: Gamma-glutamyltransferase related protein
著者Rao, K.N, Eswaramoorthy, S, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2006-08-19
公開日2006-08-29
最終更新日2021-02-03
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Crystal structure of gamma-glutamyl transferase related protein from Thermoplasma acidophilum
To be Published
2V36
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BU of 2v36 by Molmil
Crystal structure of gamma-glutamyl transferase from Bacillus subtilis
分子名称: GAMMA-GLUTAMYLTRANSPEPTIDASE LARGE CHAIN, GAMMA-GLUTAMYLTRANSPEPTIDASE SMALL CHAIN
著者Sharath, B, Prabhune, A.A, Suresh, C.G, Wilkinson, A.J, Brannigan, J.A.
登録日2007-06-13
公開日2008-07-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of Gamma-Glutamyl Transferase
To be Published
6XPC
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BU of 6xpc by Molmil
Structure of human GGT1 in complex with full GSH molecule
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTATHIONE, ...
著者Terzyan, S.S, Hanigan, M.
登録日2020-07-08
公開日2020-11-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.
J.Biol.Chem., 296, 2020
5V4Q
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BU of 5v4q by Molmil
Crystal Structure of human GGT1 in complex with DON
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5,5-dihydroxy-L-norleucine, CHLORIDE ION, ...
著者Terzyan, S, Hanigan, M.
登録日2017-03-10
公開日2017-04-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation.
Protein Sci., 26, 2017
5HFT
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BU of 5hft by Molmil
Crystal structure of HpxW
分子名称: Gamma-glutamyltranspeptidase
著者Ealick, S.E, Hicks, K.A.
登録日2016-01-07
公開日2016-06-29
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.646 Å)
主引用文献Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
Acta Crystallogr D Struct Biol, 72, 2016
4GG2
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BU of 4gg2 by Molmil
The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTAMIC ACID, ...
著者West, M.B, Chen, Y, Wickham, S, Heroux, A, Cahill, K, Hanigan, M.H, Mooers, B.H.M.
登録日2012-08-04
公開日2013-09-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Novel Insights into Eukaryotic gamma-Glutamyltranspeptidase 1 from the Crystal Structure of the Glutamate-bound Human Enzyme.
J.Biol.Chem., 288, 2013
5B5T
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BU of 5b5t by Molmil
Crystal Structure of Escherichia coli Gamma-Glutamyltranspeptidase in Complex with peptidyl phosphonate inhibitor 1b
分子名称: (2~{S})-2-azanyl-4-[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-butan-2-yl]oxyphosphonoyl-butanoic acid, CALCIUM ION, Gamma-glutamyltranspeptidase large chain, ...
著者Wada, K, Fukuyama, K.
登録日2016-05-18
公開日2016-09-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Phosphonate-based irreversible inhibitors of human gamma-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
Bioorg.Med.Chem., 24, 2016
5BPK
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BU of 5bpk by Molmil
Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
分子名称: (2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid, 1,2-ETHANEDIOL, Gamma-glutamyltranspeptidase (Ggt)
著者Bolz, C, Bach, N.C, Meyer, H, Mueller, G, Dawidowski, M, Popowicz, G, Sieber, S.A, Skerra, A, Gerhard, M.
登録日2015-05-28
公開日2016-05-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
To Be Published
5Y9B
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BU of 5y9b by Molmil
Crystal structure of Bacillus licheniformis Gamma glutamyl transpeptidase with DON
分子名称: 1,2-ETHANEDIOL, 6-DIAZENYL-5-OXO-L-NORLEUCINE, CALCIUM ION, ...
著者Goel, M, Kumari, S, Pal, R, Gupta, R.
登録日2017-08-24
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of Bacillus licheniformis Gamma glutamyl transpeptidase with Azaserine
To Be Published
5XLU
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BU of 5xlu by Molmil
High Resolution Crystal Structure of Bacillus Licheniformis Gamma Glutamyl Transpeptidase with Acivicin
分子名称: (2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID, CALCIUM ION, GLYCEROL, ...
著者Kumari, S, Goel, M, Gupta, R, Pal, R.
登録日2017-05-11
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献High Resolution Crystal Structure of Bacillus Licheniformis Gamma Glutamyl Transpeptidase with Acivicin
To Be Published
4OTT
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BU of 4ott by Molmil
Crystal structure of the gamma-glutamyltranspeptidase from Bacillus licheniformis.
分子名称: Gamma glutamyl transpeptidase, Gamma-glutamyltranspeptidase, MAGNESIUM ION
著者Merlino, A.
登録日2014-02-14
公開日2014-07-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Low resolution X-ray structure of gamma-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion.
Biochim.Biophys.Acta, 1844, 2014
4OTU
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BU of 4otu by Molmil
Crystal structure of the gamma-glutamyltranspeptidase from Bacillus licheniformis in complex with L-Glutamate
分子名称: GLUTAMIC ACID, Gamma glutamyl transpeptidase, Gamma-glutamyltranspeptidase, ...
著者Merlino, A.
登録日2014-02-14
公開日2014-07-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.022 Å)
主引用文献Low resolution X-ray structure of gamma-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion.
Biochim.Biophys.Acta, 1844, 2014
6J3A
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BU of 6j3a by Molmil
Structure of LmbA2991HD
分子名称: Gamma-glutamyltranspeptidase
著者Song, Y.
登録日2019-01-04
公開日2020-01-15
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structure of LmbA2991HD
To Be Published
6J3I
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BU of 6j3i by Molmil
Structure of LmbA2991T421A
分子名称: Gamma-glutamyltranspeptidase
著者Song, Y.
登録日2019-01-04
公開日2020-01-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of LmbA2991T421A
To Be Published
7D9X
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BU of 7d9x by Molmil
Highly active mutant W525D of Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens
分子名称: GAMMA-BUTYROLACTONE, GLYCEROL, GLYCINE, ...
著者Hibi, T, Sano, C, Itoh, T, Wakayama, M.
登録日2020-10-14
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens.
Biochem.Biophys.Res.Commun., 534, 2021
7D9E
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BU of 7d9e by Molmil
Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with L-DON
分子名称: 6-DIAZENYL-5-OXO-L-NORLEUCINE, GLYCEROL, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03
著者Hibi, T, Sano, C, Itoh, T, Wakayama, M.
登録日2020-10-13
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens.
Biochem.Biophys.Res.Commun., 534, 2021
7D9W
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BU of 7d9w by Molmil
Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with L-DON
分子名称: 6-DIAZENYL-5-OXO-L-NORLEUCINE, GLYCINE, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03
著者Hibi, T, Sano, C, Putthapong, P, Hayashi, J, Itoh, T, Wakayama, M.
登録日2020-10-14
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens.
Biochem.Biophys.Res.Commun., 534, 2021
3WHQ
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BU of 3whq by Molmil
Crystal structure of gamma-glutamyltranspeptidase from Bacillus subtilis (crystal soaked for 0 min. in acivicin soln. )
分子名称: Gamma-glutamyltranspeptidase large chain, Gamma-glutamyltranspeptidase small chain
著者Wada, K, Fukuyama, K.
登録日2013-08-30
公開日2014-02-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of Bacillus subtilis gamma-glutamyltranspeptidase in complex with acivicin: diversity of the binding mode of a classical and electrophilic active-site-directed glutamate analogue.
Acta Crystallogr.,Sect.D, 70, 2014
3WHS
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BU of 3whs by Molmil
Crystal structure of Bacillus subtilis gamma-glutamyltranspeptidase in complex with acivicin
分子名称: (2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID, Gamma-glutamyltranspeptidase large chain, Gamma-glutamyltranspeptidase small chain
著者Wada, K, Fukuyama, K.
登録日2013-08-30
公開日2014-02-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of Bacillus subtilis gamma-glutamyltranspeptidase in complex with acivicin: diversity of the binding mode of a classical and electrophilic active-site-directed glutamate analogue.
Acta Crystallogr.,Sect.D, 70, 2014
3WHR
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BU of 3whr by Molmil
Crystal structure of gamma-glutamyltranspeptidase from Bacillus subtilis (crystal soaked for 3min. in acivicin soln. )
分子名称: Gamma-glutamyltranspeptidase large chain, Gamma-glutamyltranspeptidase small chain
著者Ida, T, Suzuki, H, Fukuyama, K, Hiratake, J, Wada, K.
登録日2013-08-30
公開日2014-02-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Structure of Bacillus subtilis gamma-glutamyltranspeptidase in complex with acivicin: diversity of the binding mode of a classical and electrophilic active-site-directed glutamate analogue.
Acta Crystallogr.,Sect.D, 70, 2014
3FNM
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BU of 3fnm by Molmil
Crystal structure of acivicin-inhibited gamma-glutamyltranspeptidase reveals critical roles for its C-terminus in autoprocessing and catalysis
分子名称: (2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID, Gamma-glutamyltranspeptidase (Ggt) Large subunit, Gamma-glutamyltranspeptidase (Ggt) Small subunit
著者Williams, K, Cullati, S, Sand, A, Biterova, E.I, Barycki, J.J.
登録日2008-12-25
公開日2009-05-19
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Acivicin-Inhibited gamma-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis.
Biochemistry, 48, 2009
7LBC
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BU of 7lbc by Molmil
Structure of human GGT1 in complex with Lnt2-65 compound
分子名称: (2R)-2-[(2-aminoethyl)amino]-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Terzyan, S.S, Hanigan, M.
登録日2021-01-07
公開日2022-02-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase.
Bioorg.Med.Chem., 73, 2022
7LD9
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Structure of human GGT1 in complex with ABBA
分子名称: (2R)-2-amino-4-boronobutanoic acid, (2S)-2-amino-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Terzyan, S.S, Hanigan, M.
登録日2021-01-12
公開日2022-02-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase.
Bioorg.Med.Chem., 73, 2022

 

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