1QGT
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7OEW
| |
6J10
| Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly | 分子名称: | 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one, Capsid protein | 著者 | Park, S, Jin, M.S, Cho, Y, Kang, J, Kim, S, Park, M, Park, H, Kim, J, Park, S, Hwang, J, Kim, Y, Kim, Y.J. | 登録日 | 2018-12-27 | 公開日 | 2019-04-17 | 最終更新日 | 2019-05-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly. Nat Commun, 10, 2019
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8KHU
| Hepatitis B virus core protein Y132A mutant in complex with THPP derivatives 48 | 分子名称: | (6~{S},7~{R})-6,7-dimethyl-3-(2-oxidanylidenepyrrolidin-1-yl)-~{N}-[3,4,5-tris(fluoranyl)phenyl]-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-5-carboxamide, Capsid protein, GLYCEROL, ... | 著者 | Zhou, Z, Xu, Z.H. | 登録日 | 2023-08-22 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus. J.Med.Chem., 66, 2023
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4G93
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2QIJ
| Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data. | 分子名称: | Core antigen | 著者 | Tan, W.S, McNae, I.W, Ho, K.L, Walkinshaw, M.D. | 登録日 | 2007-07-04 | 公開日 | 2007-12-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (8.9 Å) | 主引用文献 | Crystallization and X-ray analysis of the T = 4 particle of hepatitis B capsid protein with an N-terminal extension. Acta Crystallogr.,Sect.F, 63, 2007
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7K5M
| CRYSTAL STRUCTURE OF HBV CAPSID Y132A MUTANT IN COMPLEX WITH N-(3-chloro-4-fluorophenyl)-3-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide AT 2.65A RESOLUTION | 分子名称: | Capsid protein, ISOPROPYL ALCOHOL, N-(3-chloro-4-fluorophenyl)-3-phenyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide | 著者 | Kuduk, S.D, Stoops, B, Alexander, R, Lam, A.M, Espiritu, C, Vogel, R, Lau, V, Klumpp, K, Flores, O.A, Hartman, G.D, Lukacs, C.M, Abendroth, J. | 登録日 | 2020-09-17 | 公開日 | 2021-07-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Identification of a new class of HBV capsid assembly modulator. Bioorg.Med.Chem.Lett., 39, 2021
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4BMG
| Crystal structure of hexameric HBc149 Y132A | 分子名称: | CAPSID PROTEIN | 著者 | Juergens, M.C, Alexander, C.G, Shepherd, D.A, Ashcroft, A.E, Ferguson, N. | 登録日 | 2013-05-08 | 公開日 | 2013-07-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Thermodynamic Origins of Protein Folding, Allostery and Capsid Formation in the Human Hepatitis B Virus Core Protein Proc.Natl.Acad.Sci.USA, 110, 2013
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7S76
| HBV CAPSID Y132A WITH COMPOUND 10b AT 2.5A RESOLUTION | 分子名称: | (1-methyl-1H-1,2,4-triazol-3-yl)methyl {(4S)-1-[(3-chloro-4-fluorophenyl)carbamoyl]-2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrol-4-yl}carbamate, Capsid protein | 著者 | Olland, A.M, Suto, R.K. | 登録日 | 2021-09-15 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The identification of highly efficacious functionalised tetrahydrocyclopenta[ c ]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly. Rsc Med Chem, 13, 2022
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7ABL
| HBV pgRNA T=4 NCP icosahedral symmetry | 分子名称: | Capsid protein | 著者 | Patel, N, Clark, S, Weis, E.U, Mata, C.P, Bohon, J, Farquhar, E, Ranson, N.A, Twarock, R, Stockley, P.G. | 登録日 | 2020-09-07 | 公開日 | 2021-10-27 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | In vitro functional analysis of gRNA sites regulating assembly of hepatitis B virus. Commun Biol, 4, 2021
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5GMZ
| Hepatitis B virus core protein Y132A mutant in complex with 4-methyl heteroaryldihydropyrimidine | 分子名称: | (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ... | 著者 | Xu, Z.H, Zhou, Z. | 登録日 | 2016-07-18 | 公開日 | 2016-08-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors J.Med.Chem., 59, 2016
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3V6Z
| Crystal Structure of Hepatitis B Virus e-antigen | 分子名称: | Fab e6 Heavy Chain, Fab e6 Light Chain, e-antigen | 著者 | Dimattia, M.A, Watts, N.R, Stahl, S.J, Grimes, J.M, Steven, A.C, Stuart, D.I, Wingfield, P.T. | 登録日 | 2011-12-20 | 公開日 | 2013-02-06 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | 主引用文献 | Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein. Structure, 21, 2013
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5T2P
| Hepatitis B virus core protein Y132A mutant in complex with sulfamoylbenzamide (SBA_R01) | 分子名称: | 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-~{N}-[3,4,5-tris(fluoranyl)phenyl]benzamide, CHLORIDE ION, Core protein, ... | 著者 | Zhou, Z, Xu, Z.H. | 登録日 | 2016-08-24 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.693 Å) | 主引用文献 | Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep, 7, 2017
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3KXS
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8BDZ
| Hepatitis B virus core antigen (HBc) with the insertion of four external domains of the influenza A M2 protein (HBc/4M2e) with T=4 topology | 分子名称: | Core protein,Matrix protein 2,External core antigen | 著者 | Egorov, V.V, Shvetsov, A.V, Pichkur, E.B, Shaldzhyan, A.A, Zabrodskaya, Y.A, Vinogradova, D.S, Nekrasov, P.A, Gorshkov, A.N, Garmay, Y.P, Kovaleva, A.A, Stepanova, L.A, Tsybalova, L.M, Shtam, T.A, Myasnikov, A.G, Konevega, A.L. | 登録日 | 2022-10-20 | 公開日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Inside and outside of virus-like particles HBc and HBc/4M2e: A comprehensive study of the structure. Biophys.Chem., 293, 2022
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8BER
| Hepatitis B virus core antigen (HBc) with the insertion of four external domains of the influenza A M2 protein (HBc/4M2e) with T=3 topology | 分子名称: | Core protein,Matrix protein 2,External core antigen | 著者 | Egorov, V.V, Shvetsov, A.V, Pichkur, E.B, Shaldzhyan, A.A, Zabrodskaya, Y.A, Vinogradova, D.S, Nekrasov, P.A, Gorshkov, A.N, Garmay, Y.P, Kovaleva, A.A, Stepanova, L.A, Tsybalova, L.M, Shtam, T.A, Myasnikov, A.G, Konevega, A.L. | 登録日 | 2022-10-21 | 公開日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Inside and outside of virus-like particles HBc and HBc/4M2e: A comprehensive study of the structure. Biophys.Chem., 293, 2022
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5WTW
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5WRE
| Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01) | 分子名称: | (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ... | 著者 | Zhou, Z, Xu, Z.H. | 登録日 | 2016-12-01 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.946 Å) | 主引用文献 | Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep, 7, 2017
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3J2V
| CryoEM structure of HBV core | 分子名称: | PreC/core protein | 著者 | Yu, X, Jin, L, Jih, J, Shih, C, Zhou, Z.H. | 登録日 | 2013-01-11 | 公開日 | 2013-10-02 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | 3.5 angstrom cryoEM Structure of Hepatitis B Virus Core Assembled from Full-Length Core Protein. Plos One, 8, 2013
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2G33
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5E0I
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5D7Y
| Crystal structure of Hepatitis B virus T=4 capsid in complex with the allosteric modulator HAP18 | 分子名称: | Capsid protein, methyl (4R)-4-(2-chloro-4-fluorophenyl)-6-{[4-(3-hydroxypenta-1,4-diyn-3-yl)piperidin-1-yl]methyl}-2-(pyridin-2-yl)-1,4-dihydropyrimidine-5-carboxylate | 著者 | Venkatakrishnan, B, Katen, S.P, Zlotnick, A. | 登録日 | 2015-08-14 | 公開日 | 2016-02-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.894 Å) | 主引用文献 | Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket. J.Virol., 90, 2016
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2G34
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6BVF
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6BVN
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