5D7Y

Crystal structure of Hepatitis B virus T=4 capsid in complex with the allosteric modulator HAP18

Summary for 5D7Y

• Entry DOI: 10.2210/pdb5d7y/pdb
• Descriptor: Capsid protein, methyl (4R)-4-(2-chloro-4-fluorophenyl)-6-{[4-(3-hydroxypenta-1,4-diyn-3-yl)piperidin-1-yl]methyl}-2-(pyridin-2-yl)-1,4-dihydropyrimidine-5-carboxylate (2 entities in total)
• Functional Keywords: capsid, core protein, hepadnavirus, icosahedral, assembly effector, assembly accelerator, allosteric modulator, hap, virus-inhibitor complex, virus/inhibitor
• Biological source: Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)
• Total number of polymer chains: 4
• Total formula weight: 68334.64

Authors

Venkatakrishnan, B.,Katen, S.P.,Zlotnick, A. (deposition date: 2015-08-14, release date: 2016-02-17, Last modification date: 2023-09-27)

• Primary citation: Venkatakrishnan, B.,Katen, S.P.,Francis, S.,Chirapu, S.,Finn, M.G.,Zlotnick, A.; Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket.; J.Virol., 90:3994-4004, 2016; PubMed: 26842475; DOI: 10.1128/JVI.03058-15

Experimental method

X-RAY DIFFRACTION (3.894 Å)