5E0I

Crystal structure of the HBV capsid Y132A mutant (VCID 8772) in complex with NVR10-001E2 at 1.95A resolution

Summary for 5E0I

Entry DOI	10.2210/pdb5e0i/pdb
Descriptor	Capsid protein, methyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)pyrimidine-5-carboxylate (3 entities in total)
Functional Keywords	nvr10-001e2, viral protein
Biological source	Hepatitis B virus genotype D subtype adw (HBV-D)
Cellular location	Capsid protein: Virion: P03147
Total number of polymer chains	6
Total formula weight	109089.31
Authors	Lukacs, C.M.,Abendroth, J.,Klumpp, K. (deposition date: 2015-09-28, release date: 2015-12-09, Last modification date: 2023-09-27)
Primary citation	Klumpp, K.,Lam, A.M.,Lukacs, C.,Vogel, R.,Ren, S.,Espiritu, C.,Baydo, R.,Atkins, K.,Abendroth, J.,Liao, G.,Efimov, A.,Hartman, G.,Flores, O.A. High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. Proc.Natl.Acad.Sci.USA, 112:15196-15201, 2015 Cited by PubMed: 26598693 DOI: 10.1073/pnas.1513803112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation