5E0I
Crystal structure of the HBV capsid Y132A mutant (VCID 8772) in complex with NVR10-001E2 at 1.95A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Capsid protein | polymer | 157 | 17688.2 | 6 | UniProt (P03147) Pfam (PF00906) | Hepatitis B virus genotype D subtype adw (HBV-D) | Core antigen,Core protein,HBcAg,p21.5 |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | methyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)pyrimidine-5-carboxylate | non-polymer | 493.3 | 6 | Chemie (5J6) | |||
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 440 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 149 (UniProt: P03147)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Ala 132 | Tyr 132 | engineered mutation |
| Lys 150 | - | expression tag |
| Leu 151 | - | expression tag |
| Glu 152 | - | expression tag |
| Asn 153 | - | expression tag |
| Leu 154 | - | expression tag |
| Tyr 155 | - | expression tag |
| Phe 156 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 106129.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2960.1 | |
| All* | Total formula weight | 109089.3 |
