Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

Summary for 6J10

DescriptorCapsid protein, 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one (3 entities in total)
Functional Keywordshepatitis b virus, ciclopirox, capsid assembly inhibitor, viral protein
Biological sourceHepatitis B virus genotype D subtype adw (HBV)
Total number of polymer chains6
Total molecular weight100774.18
Park, S.,Jin, M.S.,Cho, Y.,Kang, J.,Kim, S.,Park, M.,Park, H.,Kim, J.,Park, S.,Hwang, J.,Kim, Y.,Kim, Y.J. (deposition date: 2018-12-27, release date: 2019-04-17, Last modification date: 2019-05-29)
Primary citation
Kang, J.A.,Kim, S.,Park, M.,Park, H.J.,Kim, J.H.,Park, S.,Hwang, J.R.,Kim, Y.C.,Jun Kim, Y.,Cho, Y.,Sun Jin, M.,Park, S.G.
Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly.
Nat Commun, 10:2184-2184, 2019
PubMed: 31097716 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-10200-5
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.30970 4.3% 39.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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