8KHU

Hepatitis B virus core protein Y132A mutant in complex with THPP derivatives 48

Summary for 8KHU

• Entry DOI: 10.2210/pdb8khu/pdb
• Descriptor: Capsid protein, ISOPROPYL ALCOHOL, (6~{S},7~{R})-6,7-dimethyl-3-(2-oxidanylidenepyrrolidin-1-yl)-~{N}-[3,4,5-tris(fluoranyl)phenyl]-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-5-carboxamide, ... (5 entities in total)
• Functional Keywords: hbv capsid assembly mudulator, antiviral protein, viral protein
• Biological source: Hepatitis B virus adw/991
• Total number of polymer chains: 7
• Total formula weight: 125365.51

Authors

Zhou, Z.,Xu, Z.H. (deposition date: 2023-08-22, release date: 2023-10-25, Last modification date: 2023-11-08)

• Primary citation: Kou, B.,Zhang, Z.,Han, X.,Zhou, Z.,Xu, Z.,Zhou, X.,Shen, F.,Zhou, Y.,Tian, X.,Yang, G.,Young, J.A.T.,Qiu, H.,Ottaviani, G.,Mayweg, A.,Zhu, W.,Shen, H.C.,Liu, H.,Hu, T.; Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus.; J.Med.Chem., 66:14116-14132, 2023; PubMed: 37801325; DOI: 10.1021/acs.jmedchem.3c01145

Experimental method

X-RAY DIFFRACTION (2 Å)