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PDB: 286 件
4AF0
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Crystal structure of cryptococcal inosine monophosphate dehydrogenase
分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, MYCOPHENOLIC ACID, ...
著者Valkov, E, Stamp, A, Morrow, C.A, Kobe, B, Fraser, J.A.
登録日2012-01-15
公開日2012-10-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献De Novo GTP Biosynthesis is Critical for Virulence of the Fungal Pathogen Cryptococcus Neoformans
Plos Pathog., 8, 2012
6XWL
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BU of 6xwl by Molmil
Cystathionine beta-synthase from Toxoplasma gondii
分子名称: Cystathionine beta-synthase, PYRIDOXAL-5'-PHOSPHATE
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-01-23
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.201 Å)
主引用文献Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
4CFE
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BU of 4cfe by Molmil
Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
著者Xiao, B, Sanders, M.J, Carmena, D, Bright, N.J, Haire, L.F, Underwood, E, Patel, B.R, Heath, R.B, Walker, P.A, Hallen, S, Giordanetto, F, Martin, S.R, Carling, D, Gamblin, S.J.
登録日2013-11-14
公開日2013-12-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.023 Å)
主引用文献Structural Basis of Ampk Regulation by Small Molecule Activators.
Nat.Commun., 4, 2013
4AVF
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BU of 4avf by Molmil
Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase
分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
著者McMahon, S.A, Moynie, L, Liu, H, Duthie, F, Naismith, J.H.
登録日2012-05-25
公開日2013-01-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery
Acta Crystallogr.,Sect.F, 69, 2013
6XYL
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BU of 6xyl by Molmil
Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-serine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-01-30
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.151 Å)
主引用文献Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
4COO
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BU of 4coo by Molmil
Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution
分子名称: 1,2-ETHANEDIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ACETATE ION, ...
著者McCorvie, T.J, Kopec, J, Vollamar, M, Strain-Damerell, C, Bushell, S, Bradley, A, Tallant, C, Kiyani, W, Froese, D.S, Carpenter, E.S, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
登録日2014-01-29
公開日2014-03-05
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
5K25
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BU of 5k25 by Molmil
Crystal structure of human phosphatase PRL-2 in complex with the ADP-bound Bateman domain of human magnesium transporter CNNM3
分子名称: ADENOSINE-5'-DIPHOSPHATE, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2
著者Gulerez, I, Kozlov, G, Gehring, K.
登録日2016-05-18
公開日2016-10-12
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.
Sci Rep, 7, 2017
5K22
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BU of 5k22 by Molmil
Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3
分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2
著者Kozlov, G, Wu, H, Gehring, K.
登録日2016-05-18
公開日2016-10-12
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.
EMBO Rep., 17, 2016
5K23
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BU of 5k23 by Molmil
Crystal structure of the complex between human phosphatase PRL-2 in the oxidized state with the Bateman domain of human magnesium transporter CNNM3
分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2
著者Gulerez, I, Kozlov, G, Gehring, K.
登録日2016-05-18
公開日2016-10-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.
Sci Rep, 7, 2017
5KQ5
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AMPK bound to allosteric activator
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Calabrese, M.F, Kurumbail, R.G.
登録日2016-07-05
公開日2016-08-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.41 Å)
主引用文献Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J.Med.Chem., 59, 2016
3PC4
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BU of 3pc4 by Molmil
Full length structure of cystathionine beta-synthase from Drosophila in complex with serine
分子名称: (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine, CG1753, isoform A, ...
著者Koutmos, M, Smith, J.L.
登録日2010-10-21
公開日2010-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PC2
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BU of 3pc2 by Molmil
Full length structure of cystathionine beta-synthase from Drosophila
分子名称: CG1753, isoform A, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Koutmos, M, Smith, J.L.
登録日2010-10-21
公開日2010-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PC3
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BU of 3pc3 by Molmil
Full length structure of cystathionine beta-synthase from Drosophila in complex with aminoacrylate
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CG1753, isoform A, ...
著者Koutmos, M, Smith, J.L.
登録日2010-10-21
公開日2010-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
5K24
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BU of 5k24 by Molmil
Crystal structure of the complex between phosphatase PRL-2 in the oxidized state with the Bateman domain of murine magnesium transporter CNNM3
分子名称: CITRATE ANION, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2
著者Kozlov, G, Gulerez, I, Gehring, K.
登録日2016-05-18
公開日2016-10-12
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.
Sci Rep, 7, 2017
6Z3S
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BU of 6z3s by Molmil
Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with O-Acetylserine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-05-21
公開日2021-06-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.048 Å)
主引用文献Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
6ZS7
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BU of 6zs7 by Molmil
Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-cysteine
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase
著者Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A.
登録日2020-07-15
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
7AHD
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BU of 7ahd by Molmil
OpuA (E190Q) occluded
分子名称: ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
登録日2020-09-24
公開日2020-11-25
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
7AHH
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BU of 7ahh by Molmil
OpuA inhibited inward-facing, SBD docked
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component, ...
著者Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
登録日2020-09-24
公開日2020-11-25
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
7AHE
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BU of 7ahe by Molmil
OpuA inhibited inward facing
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component
著者Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
登録日2020-09-24
公開日2020-11-25
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
7AHC
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BU of 7ahc by Molmil
OpuA apo inward-facing
分子名称: ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component
著者Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B.
登録日2020-09-24
公開日2020-11-25
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
Sci Adv, 6, 2020
4L28
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BU of 4l28 by Molmil
Crystal structure of delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag
分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE
著者Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A.
登録日2013-06-04
公開日2013-09-18
最終更新日2013-10-16
実験手法X-RAY DIFFRACTION (2.626 Å)
主引用文献Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration.
Proc.Natl.Acad.Sci.USA, 110, 2013
8G9B
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BU of 8g9b by Molmil
Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
著者O'Neill, A.G, Kollman, J.M.
登録日2023-02-21
公開日2023-04-19
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
J.Biol.Chem., 299, 2023
4PCU
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BU of 4pcu by Molmil
Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet
分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ...
著者Ereno-Orbea, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez-Cruz, L.A.
登録日2014-04-16
公開日2014-09-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.578 Å)
主引用文献Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine.
Proc.Natl.Acad.Sci.USA, 111, 2014
4QFG
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BU of 4qfg by Molmil
Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic activator
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Calabrese, M.F, Kurumbail, R.G.
登録日2014-05-20
公開日2014-08-06
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.46 Å)
主引用文献Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.
Structure, 22, 2014
3USB
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BU of 3usb by Molmil
Crystal Structure of Bacillus anthracis Inosine Monophosphate Dehydrogenase in the complex with IMP
分子名称: CHLORIDE ION, GLYCEROL, INOSINIC ACID, ...
著者Kim, Y, Zhang, R, Wu, R, Gu, M, Anderson, W.F, Joachimiak, A, CSGID, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2011-11-23
公開日2011-12-07
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.
Biochemistry, 51, 2012

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