9EN2
 
 | | Crystal structure of the metalloproteinase enhancer PCPE-1 complexed with nanobodies VHH-H4 and VHH-I5 | | 分子名称: | CALCIUM ION, GLYCEROL, Procollagen C-endopeptidase enhancer 1, ... | | 著者 | Lagoutte, P, Gueguen-Chaignon, V, Bourhis, J.-M, Vadon-Le Goff, S. | | 登録日 | 2024-03-12 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens.
J.Mol.Biol., 436, 2024
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2WNO
 | | X-ray Structure of CUB_C domain from TSG-6 | | 分子名称: | CALCIUM ION, COBALT (II) ION, TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN | | 著者 | Briggs, D.C, Day, A.J. | | 登録日 | 2009-07-13 | | 公開日 | 2010-09-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Metal Ion-Dependent Heavy Chain Transfer Activity of Tsg-6 Mediates Assembly of the Cumulus-Oocyte Matrix.
J.Biol.Chem., 290, 2015
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3DEM
 | | CUB1-EGF-CUB2 domain of HUMAN MASP-1/3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement factor MASP-3 | | 著者 | Gaboriaud, C. | | 登録日 | 2008-06-10 | | 公開日 | 2008-07-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins
J.Biol.Chem., 283, 2008
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6F1D
 | | CUB2 domain of C1r | | 分子名称: | CALCIUM ION, Complement C1r subcomponent, SODIUM ION | | 著者 | Almitairi, J.O.M, Venkatraman Girija, U, Furze, C.M, Simpson-Gray, X, Badakshi, F, Marshall, J.E, Mitchell, D.A, Moody, P.C.E, Wallis, R. | | 登録日 | 2017-11-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of the C1r-C1s interaction of the C1 complex of complement activation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1SFP
 | | CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY | | 分子名称: | ASFP | | 著者 | Romao, M.J, Kolln, I, Dias, J.M, Carvalho, A.L, Romero, A, Varela, P.F, Sanz, L, Topfer-Petersen, E, Calvete, J.J. | | 登録日 | 1997-06-24 | | 公開日 | 1998-06-24 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structures of two spermadhesins reveal the CUB domain fold.
Nat.Struct.Biol., 4, 1997
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1SPP
 | | THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN | | 分子名称: | MAJOR SEMINAL PLASMA GLYCOPROTEIN PSP-I, MAJOR SEMINAL PLASMA GLYCOPROTEIN PSP-II | | 著者 | Romero, A, Romao, M.J, Varela, P.F, Kolln, I, Dias, J.M, Carvalho, A.L, Sanz, L, Topfer-Petersen, E, Calvete, J.J. | | 登録日 | 1997-06-19 | | 公開日 | 1998-06-24 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The crystal structures of two spermadhesins reveal the CUB domain fold.
Nat.Struct.Biol., 4, 1997
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3POJ
 | | Crystal structure of MASP-1 CUB2 domain bound to Ethylamine | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ETHANAMINE, ... | | 著者 | Gingras, A.R, Moody, P.C.E, Wallis, R. | | 登録日 | 2010-11-22 | | 公開日 | 2011-08-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | | 主引用文献 | Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation.
Structure, 19, 2011
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3POF
 | | Crystal structure of MASP-1 CUB2 domain bound to Ca2+ | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Mannan-binding lectin serine protease 1, ... | | 著者 | Gingras, A.R, Moody, P.C.E, Wallis, R. | | 登録日 | 2010-11-22 | | 公開日 | 2011-08-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | | 主引用文献 | Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation.
Structure, 19, 2011
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3POI
 | | Crystal structure of MASP-1 CUB2 domain bound to Methylamine | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, METHYLAMINE, ... | | 著者 | Gingras, A.R, Moody, P.C.E, Wallis, R. | | 登録日 | 2010-11-22 | | 公開日 | 2011-08-24 | | 最終更新日 | 2011-11-30 | | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | | 主引用文献 | Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation.
Structure, 19, 2011
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3POB
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3POG
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3POE
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7T4S
 | | CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein H, ... | | 著者 | Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C. | | 登録日 | 2021-12-10 | | 公開日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022
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1SZB
 | | Crystal structure of the human MBL-associated protein 19 (MAp19) | | 分子名称: | CALCIUM ION, mannose binding lectin-associated serine protease-2 related protein, MAp19 (19kDa) | | 著者 | Gregory, L.A, Thielens, N.M, Arlaud, G.J, Fontecilla-Camps, J.C, Gaboriaud, C. | | 登録日 | 2004-04-05 | | 公開日 | 2004-06-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The X-ray structure of human MBL-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin
J.Biol.Chem., 279, 2004
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3KQ4
 | | Structure of Intrinsic Factor-Cobalamin bound to its receptor Cubilin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Andersen, C.B.F, Madsen, M, Moestrup, S.K, Andersen, G.R. | | 登録日 | 2009-11-17 | | 公開日 | 2010-03-09 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.
Nature, 464, 2010
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7M0R
 | | Cryo-EM structure of the Sema3A/PlexinA4/Neuropilin 1 complex | | 分子名称: | CALCIUM ION, Neuropilin-1, Plexin-A4, ... | | 著者 | Lu, D, Shang, G, He, X, Bai, X, Zhang, X. | | 登録日 | 2021-03-11 | | 公開日 | 2021-05-05 | | 最終更新日 | 2021-06-09 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.
Nat Commun, 12, 2021
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4GZA
 | | Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1 | | 分子名称: | CALCIUM ION, Neuropilin-1, Plexin-A2, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (7 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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4GZ9
 | | Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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8IVW
 | | Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment | | 分子名称: | Heavy chian of antibody 10V8 Fab fragment, Light chain of antibody 10V8 Fab fragment, Neuropilin-2 | | 著者 | Geng, Y, Zhai, L. | | 登録日 | 2023-03-29 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.205 Å) | | 主引用文献 | Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Sci Transl Med, 15, 2023
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8IVX
 | | Crystal structure of NRP2 in complex with aNRP2-14 Fab fragment | | 分子名称: | 1,2-ETHANEDIOL, Heavy chain of antibody 14V4 Fab fragment, Light chain of antibody 14V4 Fab fragment, ... | | 著者 | Geng, Y, Zhai, L. | | 登録日 | 2023-03-29 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Sci Transl Med, 15, 2023
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7M22
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6FZW
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6FZV
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6GH8
 | | Crystal structure of GP1 domain of Lujo virus in complex with the first CUB domain of neuropilin-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Glycoprotein, ... | | 著者 | Cohen-Dvashi, H, Kilimnik, I, Diskin, R. | | 登録日 | 2018-05-06 | | 公開日 | 2018-07-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Structural basis for receptor recognition by Lujo virus.
Nat Microbiol, 3, 2018
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2QQO
 | | Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2 | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | 著者 | Appleton, B.A, Wiesmann, C. | | 登録日 | 2007-07-26 | | 公開日 | 2007-11-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
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