9EN2

Crystal structure of the metalloproteinase enhancer PCPE-1 complexed with nanobodies VHH-H4 and VHH-I5

Summary for 9EN2

Entry DOI	10.2210/pdb9en2/pdb
Descriptor	Procollagen C-endopeptidase enhancer 1, VHH-H4, VHH-I5, ... (6 entities in total)
Functional Keywords	collagen, structural protein, extracellular matrix, fibrosis, nanobodies, cell adhesion
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	64938.87
Authors	Lagoutte, P.,Gueguen-Chaignon, V.,Bourhis, J.-M.,Vadon-Le Goff, S. (deposition date: 2024-03-12, release date: 2024-07-03, Last modification date: 2024-07-17)
Primary citation	Lagoutte, P.,Bourhis, J.M.,Mariano, N.,Gueguen-Chaignon, V.,Vandroux, D.,Moali, C.,Vadon-Le Goff, S. Mono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens. J.Mol.Biol., 436:168667-168667, 2024 Cited by PubMed: 38901640 DOI: 10.1016/j.jmb.2024.168667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation