4MQ9
| Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 | 分子名称: | (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. | 登録日 | 2013-09-16 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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3UGP
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7ZF2
| Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Trapani, S, Bron, P, Lai Kee Him, J, Brodolin, K, Morichaud, Z, Vishwakarma, R. | 登録日 | 2022-03-31 | 公開日 | 2023-02-08 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization. Nat Commun, 14, 2023
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7P5X
| Mycobacterial RNAP with transcriptional activator PafBC | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. | 登録日 | 2021-07-15 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
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8AD1
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4X8K
| Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 | 分子名称: | 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ... | 著者 | Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A. | 登録日 | 2014-12-10 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc.Natl.Acad.Sci.USA, 112, 2015
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8U3B
| Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A | 分子名称: | DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Liu, B, Kompaniiets, D, Wang, D. | 登録日 | 2023-09-07 | 公開日 | 2024-01-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural basis for transcription activation by the nitrate-responsive regulator NarL. Nucleic Acids Res., 52, 2024
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7C17
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3LEV
| HIV-1 antibody 2F5 in complex with epitope scaffold ES2 | 分子名称: | 2F5 ANTIBODY HEAVY CHAIN, 2F5 ANTIBODY LIGHT CHAIN, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Baker, D, Wyatt, R, Kwong, P.D. | 登録日 | 2010-01-15 | 公開日 | 2010-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
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5X21
| Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) | 分子名称: | (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Zhang, Y, Ebright, R. | 登録日 | 2017-01-29 | 公開日 | 2017-07-05 | 最終更新日 | 2022-10-12 | 実験手法 | X-RAY DIFFRACTION (3.323 Å) | 主引用文献 | Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
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5X22
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2CW0
| Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. | 登録日 | 2005-06-15 | 公開日 | 2005-09-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation Cell(Cambridge,Mass.), 122, 2005
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3LES
| 2F5 Epitope scaffold ES2 | 分子名称: | RNA polymerase sigma factor, SULFATE ION | 著者 | Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Wyatt, R, Baker, D, Kwong, P.D. | 登録日 | 2010-01-15 | 公開日 | 2010-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
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5XJ0
| T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. | 登録日 | 2017-04-28 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (4.004 Å) | 主引用文献 | A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
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3EQL
| Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I. | 登録日 | 2008-09-30 | 公開日 | 2008-10-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Transcription inactivation through local refolding of the RNA polymerase structure. Nature, 457, 2009
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8JKE
| AfsR(T337A) transcription activation complex | 分子名称: | DNA(65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Wang, Y, Zheng, J. | 登録日 | 2023-06-01 | 公開日 | 2024-02-14 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | 主引用文献 | Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
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5YIX
| Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70 | 分子名称: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, RNA polymerase sigma factor RpoD, ... | 著者 | Wu, X, Zhang, Y. | 登録日 | 2017-10-06 | 公開日 | 2018-03-21 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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3WOD
| RNA polymerase-gp39 complex | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. | 登録日 | 2013-12-26 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
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8DY9
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8DY7
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2BE5
| Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-10-22 | 公開日 | 2005-11-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
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3DXJ
| Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... | 著者 | Das, K, Arnold, E. | 登録日 | 2008-07-24 | 公開日 | 2008-10-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135, 2008
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3UGO
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1SIG
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1SMY
| Structural basis for transcription regulation by alarmone ppGpp | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-03-10 | 公開日 | 2004-05-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for transcription regulation by alarmone ppGpp Cell(Cambridge,Mass.), 117, 2004
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