Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 730 件
3ZM1
DownloadVisualize
BU of 3zm1 by Molmil
Catalytic domain of human SHP2
分子名称: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
著者Bohm, K, Schuetz, A, Roske, Y, Heinemann, U.
登録日2013-02-04
公開日2014-04-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo.
Chemmedchem, 10, 2015
1T4J
DownloadVisualize
BU of 1t4j by Molmil
Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Protein-tyrosine phosphatase, non-receptor type 1
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-29
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11, 2004
6KRX
DownloadVisualize
BU of 6krx by Molmil
Crystal Structure of AtPTP1 at 1.7 angstrom
分子名称: CITRATE ANION, IODIDE ION, Protein-tyrosine-phosphatase PTP1
著者Zhao, Y.Y, Luo, Z.P, Wang, J, Wu, J.W.
登録日2019-08-22
公開日2020-08-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献AtPTP1 positively mediates brassinosteroid signaling from receptor kinases to GSK3-like kinase BIN2
To Be Published
1V3A
DownloadVisualize
BU of 1v3a by Molmil
Structure of human PRL-3, the phosphatase associated with cancer metastasis
分子名称: protein tyrosine phosphatase type IVA
著者Jeon, Y.H, Cheong, C.
登録日2003-10-30
公開日2004-10-30
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structure of human PRL-3, the phosphatase associated with cancer metastasis
Febs Lett., 565, 2004
1T49
DownloadVisualize
BU of 1t49 by Molmil
Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID (4-SULFAMOYL-PHENYL)-AMIDE, MAGNESIUM ION, Protein-tyrosine phosphatase, ...
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-28
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B.
Nat.Struct.Mol.Biol., 11, 2004
1SUG
DownloadVisualize
BU of 1sug by Molmil
1.95 A structure of apo protein tyrosine phosphatase 1B
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Protein-tyrosine phosphatase, ...
著者Pedersen, A.K, Peters, G.H, Moller, K.B, Iversen, L.F, Kastrup, J.S.
登録日2004-03-26
公開日2004-09-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B.
Acta Crystallogr.,Sect.D, 60, 2004
1WAX
DownloadVisualize
BU of 1wax by Molmil
Protein tyrosine phosphatase 1B with active site inhibitor
分子名称: MAGNESIUM ION, PROTEIN-TYROSINE PHOSPHATASE, [[4-(AMINOMETHYL)PHENYL]AMINO]OXO-ACETIC ACID,
著者Hartshorn, M.J, Murray, C.W, Cleasby, A, Frederickson, M, Tickle, I.J, Jhoti, H.
登録日2004-10-28
公開日2005-01-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Fragment-Based Lead Discovery Using X-Ray Crystallography
J.Med.Chem., 48, 2005
6PGT
DownloadVisualize
BU of 6pgt by Molmil
Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, vanadate bound state
分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-06-24
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PHA
DownloadVisualize
BU of 6pha by Molmil
Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, vanadate bound state
分子名称: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ...
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-06-25
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.299 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PHS
DownloadVisualize
BU of 6phs by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P185A mutant, vanadate bound state
分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-06-25
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.129 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PG0
DownloadVisualize
BU of 6pg0 by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P188A mutant, vanadate bound state
分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-06-23
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PFW
DownloadVisualize
BU of 6pfw by Molmil
Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, apo state
分子名称: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-06-22
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PM8
DownloadVisualize
BU of 6pm8 by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, vanadate bound state
分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-07-01
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
3M4U
DownloadVisualize
BU of 3m4u by Molmil
Crystal Structure of Trypanosoma brucei Protein Tyrosine Phosphatase TbPTP1
分子名称: PHOSPHATE ION, Tyrosine specific protein phosphatase, putative
著者Chou, S, Alber, T, Grundner, C.
登録日2010-03-12
公開日2010-05-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.392 Å)
主引用文献The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46.
J.Biol.Chem., 285, 2010
3O4S
DownloadVisualize
BU of 3o4s by Molmil
Crystal Structure of HePTP with a Closed WPD Loop and an Ordered E-Loop
分子名称: GLYCEROL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 7
著者Critton, D.A, Page, R.
登録日2010-07-27
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop.
J.Mol.Biol., 405, 2011
3O4T
DownloadVisualize
BU of 3o4t by Molmil
Crystal Structure of HePTP with an Open WPD Loop and Partially Depleted Active Site
分子名称: D(-)-TARTARIC ACID, GLYCEROL, SULFATE ION, ...
著者Critton, D.A, Page, R.
登録日2010-07-27
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop.
J.Mol.Biol., 405, 2011
3O5X
DownloadVisualize
BU of 3o5x by Molmil
Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor
分子名称: 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11
著者Zhang, Z.-Y, Zhang, X, He, Y, Liu, S, Yu, Z, Jiang, Z, Yang, Z, Dong, Y, Nabinger, S.C, Wu, L, Gunawan, A.M, Wang, L, Chan, R.J.
登録日2010-07-28
公開日2010-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
J.Med.Chem., 53, 2010
6OL4
DownloadVisualize
BU of 6ol4 by Molmil
Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, apo state
分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-04-15
公開日2020-03-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6OMY
DownloadVisualize
BU of 6omy by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, apo state
分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
著者Cui, D.S, Lipchock, J.M, Loria, J.P.
登録日2019-04-19
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
3MOW
DownloadVisualize
BU of 3mow by Molmil
Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
分子名称: (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, Tyrosine-protein phosphatase non-receptor type 11
著者Zhang, Z.-Y, Liu, S, Yu, Z, Yu, X.
登録日2010-04-23
公開日2011-05-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
To be Published
3OLR
DownloadVisualize
BU of 3olr by Molmil
PTPN22 in complex with consensus phospho-tyrosine peptide 1
分子名称: SKAP2, Tyrosine-protein phosphatase non-receptor type 22
著者Yu, X, Sun, J.-P, Zhang, S, Zhang, Z.-Y.
登録日2010-08-26
公開日2011-06-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure basis of LYP substrate specificity revealed by reverse alanine screening and crystallography
To be Published
3OMH
DownloadVisualize
BU of 3omh by Molmil
Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide
分子名称: Src kinase-associated phosphoprotein 2, Tyrosine-protein phosphatase non-receptor type 22
著者Yu, X, Sun, J.-P, Zhang, S, Zhang, Z.-Y.
登録日2010-08-26
公開日2011-06-29
最終更新日2011-09-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate.
J.Biol.Chem., 286, 2011
3O4U
DownloadVisualize
BU of 3o4u by Molmil
Crystal Structure of HePTP with an Atypically Open WPD Loop
分子名称: GLYCEROL, L(+)-TARTARIC ACID, S,R MESO-TARTARIC ACID, ...
著者Critton, D.A, Page, R.
登録日2010-07-27
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop.
J.Mol.Biol., 405, 2011
7PPL
DownloadVisualize
BU of 7ppl by Molmil
SHP2 catalytic domain in complex with IRS1 (625-639) phosphopeptide (pTyr-632, pSer-636)
分子名称: ETHANOL, GLYCEROL, Insulin receptor substrate 1, ...
著者Sok, P, Zeke, A, Remenyi, A.
登録日2021-09-14
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022
7PPN
DownloadVisualize
BU of 7ppn by Molmil
SHP2 catalytic domain in complex with CD28 (183-198) phosphopeptide (pTyr-191, p-Thr-195)
分子名称: GLYCEROL, T-cell-specific surface glycoprotein CD28, Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11
著者Sok, P, Zeke, A, Remenyi, A.
登録日2021-09-14
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon