7PPL
SHP2 catalytic domain in complex with IRS1 (625-639) phosphopeptide (pTyr-632, pSer-636)
Summary for 7PPL
Entry DOI | 10.2210/pdb7ppl/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11, Insulin receptor substrate 1, GLYCEROL, ... (5 entities in total) |
Functional Keywords | irs1, phosphatase, shp2, insulin signaling, insulin receptor substrate 1, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34897.24 |
Authors | Sok, P.,Zeke, A.,Remenyi, A. (deposition date: 2021-09-14, release date: 2022-09-07, Last modification date: 2024-01-31) |
Primary citation | Zeke, A.,Takacs, T.,Sok, P.,Nemeth, K.,Kirsch, K.,Egri, P.,Poti, A.L.,Bento, I.,Tusnady, G.E.,Remenyi, A. Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling. Nat Commun, 13:5439-5439, 2022 Cited by PubMed: 36114179DOI: 10.1038/s41467-022-32918-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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