7PPL
SHP2 catalytic domain in complex with IRS1 (625-639) phosphopeptide (pTyr-632, pSer-636)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11 | polymer | 282 | 32629.9 | 1 | UniProt (Q06124) Pfam (PF00102) In PDB | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3,Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3 |
2 | B | Insulin receptor substrate 1 | polymer | 15 | 1760.8 | 1 | UniProt (P35568) In PDB | Homo sapiens | IRS-1 |
3 | A | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
4 | A | ETHANOL | non-polymer | 46.1 | 1 | Chemie (EOH) | |||
5 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A: 5 - 73 (UniProt: Q06124)
A: 78 - 282 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
Gly 3 | - | expression tag |
Ser 4 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 74 | - | linker |
Ser 75 | - | linker |
Ser 76 | - | linker |
Gly 77 | - | linker |
Ser 213 | Cys 459 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 34390.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 506.5 | |
All* | Total formula weight | 34897.2 |