1VSO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1vso by Molmil](/molmil-images/mine/1vso) | Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex With the Antagonist (S)-ATPO at 1.85 A resolution | 分子名称: | (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, GLYCEROL, Glutamate receptor, ... | 著者 | Hald, H, Naur, P, Gajhede, M, Kastrup, J.S. | 登録日 | 2007-03-29 | 公開日 | 2007-07-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282, 2007
|
|
2I0C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2i0c by Molmil](/molmil-images/mine/2i0c) | |
2I0B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2i0b by Molmil](/molmil-images/mine/2i0b) | |
2I3W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2i3w by Molmil](/molmil-images/mine/2i3w) | Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant | 分子名称: | GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID | 著者 | Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. | 登録日 | 2006-08-21 | 公開日 | 2006-10-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
|
|
6Q54
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6q54 by Molmil](/molmil-images/mine/6q54) | Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution | 分子名称: | (2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, CHLORIDE ION, CITRIC ACID, ... | 著者 | Moellerud, S, Temperini, P, Kastrup, J.S. | 登録日 | 2018-12-07 | 公開日 | 2019-04-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J.Med.Chem., 62, 2019
|
|
2GFE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2gfe by Molmil](/molmil-images/mine/2gfe) | |
2I3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2i3v by Molmil](/molmil-images/mine/2i3v) | Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant | 分子名称: | GLUTAMIC ACID, Glutamate receptor 2, ZINC ION | 著者 | Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. | 登録日 | 2006-08-21 | 公開日 | 2006-10-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
|
|
6Q60
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6q60 by Molmil](/molmil-images/mine/6q60) | Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution | 分子名称: | (2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Moellerud, S, Temperini, P, Kastrup, J.S. | 登録日 | 2018-12-10 | 公開日 | 2019-04-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J.Med.Chem., 62, 2019
|
|
1YCJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ycj by Molmil](/molmil-images/mine/1ycj) | Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate | 分子名称: | GLUTAMIC ACID, Ionotropic glutamate receptor 5, SULFATE ION | 著者 | Naur, P, Vestergaard, B, Skov, L.K, Egebjerg, J, Gajhede, M, Kastrup, J.S. | 登録日 | 2004-12-22 | 公開日 | 2005-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate Febs Lett., 579, 2005
|
|
6QKC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qkc by Molmil](/molmil-images/mine/6qkc) | GluA1/2 In complex with auxiliary subunit gamma-8 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 1, ... | 著者 | Herguedas, B, Garcia-Nafria, J, Greger, I.G. | 登録日 | 2019-01-28 | 公開日 | 2019-03-27 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
|
|
1XHY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xhy by Molmil](/molmil-images/mine/1xhy) | X-ray structure of the Y702F mutant of the GluR2 ligand-binding core (S1S2J) in complex with kainate at 1.85 A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor, SULFATE ION | 著者 | Frandsen, A, Pickering, D.S, Vestergaard, B, Kasper, C, Nielsen, B.B, Greenwood, J.R, Campiani, G, Gajhede, M, Schousboe, A, Kastrup, J.S. | 登録日 | 2004-09-21 | 公開日 | 2005-03-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2. Mol.Pharmacol., 67, 2005
|
|
5BUU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5buu by Molmil](/molmil-images/mine/5buu) | Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution | 分子名称: | (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, 1,2-ETHANEDIOL, GLUTAMIC ACID, ... | 著者 | Larsen, A.P, Tapken, D, Frydenvang, K, Kastrup, J.S. | 登録日 | 2015-06-04 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. Acs Chem Neurosci, 7, 2016
|
|
5DT6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dt6 by Molmil](/molmil-images/mine/5dt6) | |
2F36
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f36 by Molmil](/molmil-images/mine/2f36) | |
1Y1M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y1m by Molmil](/molmil-images/mine/1y1m) | |
1Y1Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y1z by Molmil](/molmil-images/mine/1y1z) | |
1Y20
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y20 by Molmil](/molmil-images/mine/1y20) | |
1YAE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yae by Molmil](/molmil-images/mine/1yae) | Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid | 分子名称: | (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor, ... | 著者 | Nanao, M.H, Green, T, Stern-Bach, Y, Heinemann, S.F, Choe, S. | 登録日 | 2004-12-17 | 公開日 | 2005-02-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid. Proc.Natl.Acad.Sci.USA, 102, 2005
|
|
6WHY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6why by Molmil](/molmil-images/mine/6why) | GluN1b-GluN2B NMDA receptor in complex with GluN1 antagonist L689,560, class 1 | 分子名称: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chou, T, Tajima, N, Furukawa, H. | 登録日 | 2020-04-08 | 公開日 | 2020-07-15 | 最終更新日 | 2020-08-05 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
|
|
4NF5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nf5 by Molmil](/molmil-images/mine/4nf5) | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5 | 分子名称: | 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ... | 著者 | Jespersen, A, Tajima, N, Furukawa, H. | 登録日 | 2013-10-30 | 公開日 | 2014-03-12 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
|
|
3FAT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fat by Molmil](/molmil-images/mine/3fat) | X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-AMPA at 1.90A resolution | 分子名称: | (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, ACETIC ACID, GLYCEROL, ... | 著者 | Kasper, C, Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. | 登録日 | 2008-11-18 | 公開日 | 2008-12-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 Febs Lett., 582, 2008
|
|
3FVK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fvk by Molmil](/molmil-images/mine/3fvk) | Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-deoxy-neodysiherbaine A in space group P1 | 分子名称: | (2R,3aR,6S,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-6-hydroxy-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... | 著者 | Unno, M, Sasaki, M, Ikeda-Saito, M. | 登録日 | 2009-01-15 | 公開日 | 2010-01-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
|
|
3FUZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fuz by Molmil](/molmil-images/mine/3fuz) | Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with L-glutamate in space group P1 | 分子名称: | GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 1, ... | 著者 | Unno, M, Sasaki, M, Ikeda-Saito, M. | 登録日 | 2009-01-15 | 公開日 | 2010-01-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
|
|
3FVO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fvo by Molmil](/molmil-images/mine/3fvo) | Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1 | 分子名称: | (2R,3aR,6R,7S,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-6,7-dihydroxy-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... | 著者 | Unno, M, Sasaki, M, Ikeda-Saito, M. | 登録日 | 2009-01-16 | 公開日 | 2010-01-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structures of Human GluR5 Ligand-Binding Core in Complexes with Novel Marine-Derived Toxins, Dysiherbaine and Neodysiherbaine A, and Their Analogues To be Published
|
|
3FVN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fvn by Molmil](/molmil-images/mine/3fvn) | Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 9-deoxy-neodysiherbaine A in space group P1 | 分子名称: | (2R,3aR,7R,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-7-hydroxy-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... | 著者 | Unno, M, Sasaki, M, Ikeda-Saito, M. | 登録日 | 2009-01-16 | 公開日 | 2010-01-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
|
|