6Q60

Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution

Summary for 6Q60

• Entry DOI: 10.2210/pdb6q60/pdb
• Descriptor: Glutamate receptor 2, (2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, SULFATE ION, ... (7 entities in total)
• Functional Keywords: ampa receptor, glua2-s1s2, ligand binding domain, agonist, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 60539.42

Authors

Moellerud, S.,Temperini, P.,Kastrup, J.S. (deposition date: 2018-12-10, release date: 2019-04-17, Last modification date: 2024-01-24)

• Primary citation: Sainas, S.,Temperini, P.,Farnsworth, J.C.,Yi, F.,Mollerud, S.,Jensen, A.A.,Nielsen, B.,Passoni, A.,Kastrup, J.S.,Hansen, K.B.,Boschi, D.,Pickering, D.S.,Clausen, R.P.,Lolli, M.L.; Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.; J.Med.Chem., 62:4467-4482, 2019; PubMed: 30943028; DOI: 10.1021/acs.jmedchem.8b01986

Experimental method

X-RAY DIFFRACTION (1.55 Å)