6Q60

Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue HJH A 301

Chain	Residue
A	TYR61
A	MET196
A	TYR220
A	HOH413
A	HOH540
A	HOH542
A	PRO89
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 302

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH407
A	HOH418
A	HOH470
A	HOH566

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG31
A	HOH409
A	HOH444
A	HOH463
A	HOH594
B	LYS183

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL A 304

Chain	Residue
A	ASP248
A	HOH458
A	HOH571
A	HOH626
B	ASN214
B	ASP216
B	SER217

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 305

Chain	Residue
A	SER194
A	THR195
A	GLU198
A	ASN214
A	HOH401

---

site_id	AC6
Number of Residues	9
Details	binding site for residue GOL A 306

Chain	Residue
A	ILE113
A	SER123
A	ALA124
A	GLY212
A	GLY213
A	LEU215
A	HOH434
A	HOH489
A	HOH638

---

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 307

Chain	Residue
A	ARG148
A	TRP159
A	ARG163
A	HOH584

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL A 308

Chain	Residue
A	GLU97
A	ASP101
A	PHE102
A	HOH436
A	HOH500
B	LYS104

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL A 309

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	HOH551
B	ASP248

---

site_id	AD1
Number of Residues	2
Details	binding site for residue CL A 310

Chain	Residue
A	ASN22
A	HOH744

---

site_id	AD2
Number of Residues	1
Details	binding site for residue CL A 311

Chain	Residue
A	ALA153

---

site_id	AD3
Number of Residues	3
Details	binding site for residue LI A 312

Chain	Residue
A	GLU97
A	ILE100
A	HOH436

---

site_id	AD4
Number of Residues	13
Details	binding site for residue HJH B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	MET196
B	HOH412
B	HOH514
B	HOH526

---

site_id	AD5
Number of Residues	5
Details	binding site for residue SO4 B 302

Chain	Residue
B	LYS82
B	LYS116
B	HOH407
B	HOH515
B	HOH539

---

site_id	AD6
Number of Residues	7
Details	binding site for residue SO4 B 303

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH406
B	HOH476
B	HOH536
B	HOH620

---

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL B 304

Chain	Residue
A	LYS258
B	MET19
B	HIS23
B	HOH458
B	HOH566

---

site_id	AD8
Number of Residues	5
Details	binding site for residue GOL B 305

Chain	Residue
A	ASN3
A	HOH648
B	ARG31
B	LYS52
B	HOH410

---

site_id	AD9
Number of Residues	8
Details	binding site for residue GOL B 306

Chain	Residue
A	LYS104
B	GLU97
B	ASP101
B	PHE102
B	LI311
B	HOH440
B	HOH457
B	HOH628

---

site_id	AE1
Number of Residues	4
Details	binding site for residue GOL B 307

Chain	Residue
B	HIS46
B	LYS240
B	GLN244
B	HOH610

---

site_id	AE2
Number of Residues	3
Details	binding site for residue GOL B 308

Chain	Residue
B	ARG148
B	TRP159
B	ARG163

---

site_id	AE3
Number of Residues	8
Details	binding site for residue GOL B 309

Chain	Residue
A	LEU94
A	GLU98
B	HIS46
B	LEU236
B	ALA237
B	LYS240
B	HOH401
B	HOH610

---

site_id	AE4
Number of Residues	2
Details	binding site for residue CL B 310

Chain	Residue
B	LYS4
B	THR5

---

site_id	AE5
Number of Residues	5
Details	binding site for residue LI B 311

Chain	Residue
B	GLU97
B	ILE100
B	ASP101
B	GOL306
B	HOH457

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---