Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue HJH A 301 |
| Chain | Residue |
| A | TYR61 |
| A | MET196 |
| A | TYR220 |
| A | HOH413 |
| A | HOH540 |
| A | HOH542 |
| A | PRO89 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | LEU192 |
| A | GLU193 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | SER140 |
| A | LYS144 |
| A | ARG148 |
| A | HOH407 |
| A | HOH418 |
| A | HOH470 |
| A | HOH566 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | ARG31 |
| A | HOH409 |
| A | HOH444 |
| A | HOH463 |
| A | HOH594 |
| B | LYS183 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | ASP248 |
| A | HOH458 |
| A | HOH571 |
| A | HOH626 |
| B | ASN214 |
| B | ASP216 |
| B | SER217 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | SER194 |
| A | THR195 |
| A | GLU198 |
| A | ASN214 |
| A | HOH401 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | ILE113 |
| A | SER123 |
| A | ALA124 |
| A | GLY212 |
| A | GLY213 |
| A | LEU215 |
| A | HOH434 |
| A | HOH489 |
| A | HOH638 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
| A | HOH584 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | GLU97 |
| A | ASP101 |
| A | PHE102 |
| A | HOH436 |
| A | HOH500 |
| B | LYS104 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | ASN214 |
| A | ASP216 |
| A | SER217 |
| A | HOH551 |
| B | ASP248 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 310 |
| Chain | Residue |
| A | ASN22 |
| A | HOH744 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 311 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue LI A 312 |
| Chain | Residue |
| A | GLU97 |
| A | ILE100 |
| A | HOH436 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue HJH B 301 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | MET196 |
| B | HOH412 |
| B | HOH514 |
| B | HOH526 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | LYS82 |
| B | LYS116 |
| B | HOH407 |
| B | HOH515 |
| B | HOH539 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | SER140 |
| B | LYS144 |
| B | ARG148 |
| B | HOH406 |
| B | HOH476 |
| B | HOH536 |
| B | HOH620 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| A | LYS258 |
| B | MET19 |
| B | HIS23 |
| B | HOH458 |
| B | HOH566 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| A | ASN3 |
| A | HOH648 |
| B | ARG31 |
| B | LYS52 |
| B | HOH410 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 306 |
| Chain | Residue |
| A | LYS104 |
| B | GLU97 |
| B | ASP101 |
| B | PHE102 |
| B | LI311 |
| B | HOH440 |
| B | HOH457 |
| B | HOH628 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 307 |
| Chain | Residue |
| B | HIS46 |
| B | LYS240 |
| B | GLN244 |
| B | HOH610 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 308 |
| Chain | Residue |
| B | ARG148 |
| B | TRP159 |
| B | ARG163 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 309 |
| Chain | Residue |
| A | LEU94 |
| A | GLU98 |
| B | HIS46 |
| B | LEU236 |
| B | ALA237 |
| B | LYS240 |
| B | HOH401 |
| B | HOH610 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 310 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue LI B 311 |
| Chain | Residue |
| B | GLU97 |
| B | ILE100 |
| B | ASP101 |
| B | GOL306 |
| B | HOH457 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | PRO89 | |
| B | SER142 | |
| B | THR143 | |
| B | GLU193 | |
| A | THR91 | |
| A | ARG96 | |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| B | PRO89 | |
| B | THR91 | |
| B | ARG96 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ARG148 | |
| A | LYS240 | |
| B | ARG64 | |
| B | ARG148 | |
| B | LYS240 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| B | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| B | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| B | SER184 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| B | ASN3 | |
