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PDB: 663 件

5WEN
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GluA2 bound to GSG1L in digitonin, state 2
分子名称: Digitonin, Glutamate receptor 2,Germ cell-specific gene 1-like protein
著者Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I.
登録日2017-07-10
公開日2017-08-02
最終更新日2021-08-25
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
Nature, 549, 2017
4UQK
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BU of 4uqk by Molmil
Electron density map of GluA2em in complex with quisqualate and LY451646
分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2
著者Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
登録日2014-06-24
公開日2014-08-13
最終更新日2017-08-02
実験手法ELECTRON MICROSCOPY (16.4 Å)
主引用文献Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014
5JEI
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BU of 5jei by Molmil
Crystal structure of the GluA2 LBD in complex with FW
分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, ...
著者Eibl, C, Salazar, H, Chebli, M, Plested, A.J.R.
登録日2016-04-18
公開日2017-02-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.229 Å)
主引用文献Mechanism of partial agonism in AMPA-type glutamate receptors.
Nat Commun, 8, 2017
1WVJ
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BU of 1wvj by Molmil
Exploring the GluR2 ligand-binding core in complex with the bicyclic AMPA analogue (S)-4-AHCP
分子名称: 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, GLYCEROL, SULFATE ION, ...
著者Nielsen, B.B, Pickering, D.S, Greenwood, J.R, Brehm, L, Gajhede, M, Schousboe, A, Kastrup, J.S.
登録日2004-12-15
公開日2005-04-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP
FEBS J., 272, 2005
6XSR
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BU of 6xsr by Molmil
Crystal structure of GluA2 AMPA receptor in complex with trans-4-butylcyclohexane carboxylic acid (4-BCCA) inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2, trans-4-butylcyclohexane-1-carboxylic acid
著者Yelshanskaya, M.V, Singh, A.K, Sobolevsky, A.I.
登録日2020-07-16
公開日2020-12-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.25 Å)
主引用文献Structural basis of AMPA receptor inhibition by trans-4-butylcyclohexane carboxylic acid.
Br.J.Pharmacol., 179, 2022
6ZYU
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BU of 6zyu by Molmil
Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549
分子名称: (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, ACETATE ION, ...
著者Dorosz, J, Christensen, K.M, Kastrup, J.S.
登録日2020-08-03
公開日2021-08-11
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.
Acs Chem Neurosci, 12, 2021
6CNA
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BU of 6cna by Molmil
GluN1-GluN2B NMDA receptors with exon 5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Furukawa, H, Grant, T, Grigorieff, N.
登録日2018-03-07
公開日2018-10-03
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
3KFM
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BU of 3kfm by Molmil
Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with kainate
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 4
著者Gill, A, Madden, D.R.
登録日2009-10-27
公開日2010-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors.
J.Neurosci., 30, 2010
8USX
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BU of 8usx by Molmil
Glycine-bound GluN1a-3A NMDA receptor
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 3A
著者Michalski, K, Furukawa, H.
登録日2023-10-30
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
7YSJ
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GluK1-1a in nanodisc captured in SYM2081 bound desensitized state
分子名称: Glutamate receptor
著者Dhingra, S, Kumar, J.
登録日2022-08-12
公開日2023-08-16
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Functional Implications of the Exon 9 Splice Insert in GluK1 Kainate Receptors
Elife, 2023
7Z2R
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BU of 7z2r by Molmil
Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics
分子名称: Glutamate receptor ionotropic, delta-1, SULFATE ION
著者Masternak, M, Laulumaa, S, Kastrup, J.S.
登録日2022-02-28
公開日2023-01-11
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.574 Å)
主引用文献Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics.
Febs J., 290, 2023
8UUE
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BU of 8uue by Molmil
Glycine-bound GluN1a-3A LBD heterotetramer (local refinement)
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 3A
著者Michalski, K, Furukawa, H.
登録日2023-11-01
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
3LSW
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BU of 3lsw by Molmil
Aniracetam bound to the ligand binding domain of GluA3
分子名称: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, GLUTAMIC ACID, GluA2 S1S2 domain, ...
著者Ahmed, A.H, Oswald, R.E.
登録日2010-02-13
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
4X48
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BU of 4x48 by Molmil
Crystal structure of GluR2 ligand-binding core
分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide, ...
著者Pandit, J.
登録日2014-12-02
公開日2015-05-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).
J.Med.Chem., 58, 2015
4WXJ
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BU of 4wxj by Molmil
Drosophila muscle GluRIIB complex with glutamate
分子名称: GLUTAMIC ACID, Glutamate receptor IIB,Glutamate receptor IIB
著者Dharkar, P, Mayer, M.L.
登録日2014-11-13
公開日2015-04-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.
Proc.Natl.Acad.Sci.USA, 112, 2015
7KS0
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BU of 7ks0 by Molmil
GluK2/K5 with 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX)
分子名称: Glutamate receptor ionotropic, kainate 2, kainate 5,Green fluorescent protein chimera
著者Khanra, N, Brown, P.M.G.E, Perozzo, A.M, Bowie, D, Meyerson, J.R.
登録日2020-11-20
公開日2021-03-24
最終更新日2021-07-07
実験手法ELECTRON MICROSCOPY (5.3 Å)
主引用文献Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor.
Elife, 10, 2021
7KS3
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BU of 7ks3 by Molmil
GluK2/K5 with L-Glu
分子名称: Glutamate receptor ionotropic, kainate 2, kainate 5,Green fluorescent protein chimera
著者Khanra, N, Brown, P.M.G.E, Perozzo, A.M, Bowie, D, Meyerson, J.R.
登録日2020-11-20
公開日2021-03-24
最終更新日2021-07-07
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor.
Elife, 10, 2021
6DM0
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BU of 6dm0 by Molmil
Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction
分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
著者Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
登録日2018-06-04
公開日2018-08-22
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6DM1
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BU of 6dm1 by Molmil
Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction
分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
著者Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
登録日2018-06-04
公開日2018-08-22
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6DLZ
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BU of 6dlz by Molmil
Open state GluA2 in complex with STZ after micelle signal subtraction
分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit
著者Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
登録日2018-06-04
公開日2018-08-22
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
4N07
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BU of 4n07 by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution
分子名称: 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, CACODYLATE ION, ...
著者Noerholm, A.B, Frydenvang, K, Kastrup, J.S.
登録日2013-10-01
公開日2013-11-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.
J.Med.Chem., 56, 2013
4NF6
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Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA
分子名称: (2S,3R)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid, GLYCINE, Glutamate receptor ionotropic, ...
著者Jespersen, A, Tajima, N, Furukawa, H.
登録日2013-10-30
公開日2014-03-12
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
4NF8
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Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in PEG2000MME
分子名称: GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ...
著者Jespersen, A, Tajima, N, Furukawa, H.
登録日2013-10-30
公開日2014-03-12
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.856 Å)
主引用文献Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
3U92
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Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ...
著者Kumar, J, Mayer, M.L.
登録日2011-10-17
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.
Neuron, 76, 2012
6R85
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Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with L-glutamate
分子名称: 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutamate receptor 3.3,Glutamate receptor 3.3, ...
著者Alfieri, A, Pederzoli, R, Costa, A.
登録日2019-03-31
公開日2020-01-01
最終更新日2020-01-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel.
Proc.Natl.Acad.Sci.USA, 117, 2020

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