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PDB: 594 件
7SA7
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Crystal structure of the apo SH2 domains of Syk
分子名称: Tyrosine-protein kinase SYK
著者Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J.
登録日2021-09-22
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein Sci., 30, 2021
5W3R
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BU of 5w3r by Molmil
SH2B1 SH2 Domain
分子名称: PHENOL, PHOSPHATE ION, SH2B adapter protein 1
著者McKercher, M.A, Wuttke, D.S.
登録日2017-06-08
公開日2017-11-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.386 Å)
主引用文献Diversity in peptide recognition by the SH2 domain of SH2B1.
Proteins, 86, 2018
4P9Z
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Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Clements, J.H, Martin, S.F.
登録日2014-04-06
公開日2014-06-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction.
Bioorg.Med.Chem.Lett., 24, 2014
6E8M
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BU of 6e8m by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide
分子名称: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327)
著者Kaneko, T, Li, S.S.C.
登録日2018-07-30
公開日2018-11-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
7CIO
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BU of 7cio by Molmil
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
分子名称: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha
著者Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M.
登録日2020-07-08
公開日2020-12-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
1MIL
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TRANSFORMING PROTEIN
分子名称: SHC ADAPTOR PROTEIN
著者Mikol, V.
登録日1995-09-20
公開日1996-11-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data.
J.Mol.Biol., 254, 1995
2GE9
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BU of 2ge9 by Molmil
Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase
分子名称: Tyrosine-protein kinase BTK
著者Cheng, J.-W, Huang, K.-C.
登録日2006-03-18
公開日2006-10-24
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase
J.Biomol.Nmr, 36, 2006
6R5G
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BU of 6r5g by Molmil
C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1
分子名称: ITSM, Tyrosine-protein phosphatase non-receptor type 11
著者Marasco, M.
登録日2019-03-25
公開日2020-02-05
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
1MW4
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BU of 1mw4 by Molmil
Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139
分子名称: Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2
著者Ivancic, M, Lyons, B.A.
登録日2002-09-27
公開日2003-09-09
最終更新日2012-05-02
実験手法SOLUTION NMR
主引用文献Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2
J.BIOMOL.NMR, 27, 2003
6ROZ
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BU of 6roz by Molmil
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif
分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM)
著者Krausze, J, Sikorska, J, Carlomagno, T.
登録日2019-05-13
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
2H5K
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BU of 2h5k by Molmil
Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2
分子名称: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand
著者Benfield, A.P, Whiddon, B.B, Martin, S.F.
登録日2006-05-26
公開日2006-08-15
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
6ROY
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Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif
分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM)
著者Krausze, J, Sikorska, J, Carlomagno, T.
登録日2019-05-13
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
2RSY
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BU of 2rsy by Molmil
Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp
分子名称: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK
著者Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T.
登録日2012-09-10
公開日2013-04-10
最終更新日2019-12-25
実験手法SOLUTION NMR
主引用文献Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.
J.Biol.Chem., 288, 2013
2RMX
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BU of 2rmx by Molmil
Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
分子名称: NKG2-A/NKG2-B type II integral membrane protein, Tyrosine-protein phosphatase non-receptor type 6
著者Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-11-30
公開日2008-12-02
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1
To be Published
6SM5
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MbC/SHP1-C-SH2 complex
分子名称: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6
著者Mann, G, Hantschel, O.
登録日2019-08-21
公開日2021-01-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献MbC/SHP1-C-SH2 complex
To Be Published
6E8I
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BU of 6e8i by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to phosphotyrosine
分子名称: LeSH (Llo2327), O-PHOSPHOTYROSINE
著者Kaneko, T, Li, S.S.C.
登録日2018-07-29
公開日2018-11-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
6E8K
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BU of 6e8k by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide
分子名称: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide
著者Kaneko, T, Li, S.S.C.
登録日2018-07-30
公開日2018-11-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
6PXC
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BU of 6pxc by Molmil
N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide
分子名称: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP
著者Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
登録日2019-07-25
公開日2019-12-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
6PXB
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N-Terminal SH2 domain of the p120RasGAP
分子名称: Ras GTPase-activating protein 1
著者Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
登録日2019-07-25
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.747 Å)
主引用文献Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
7WFY
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BU of 7wfy by Molmil
Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide
分子名称: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2
著者Zhang, Y.J, Liu, Y.R, Wu, B.
登録日2021-12-27
公開日2022-12-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.449 Å)
主引用文献Vav2 is a novel APP-interacting protein that regulates APP protein level.
Sci Rep, 12, 2022
7MPH
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BU of 7mph by Molmil
GRB2 SH2 Domain with Compound 7
分子名称: (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ...
著者Sun, L, Schonbrunn, E.
登録日2021-05-04
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain.
Bioorg.Med.Chem.Lett., 51, 2021
6E8H
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Legionella Longbeachae LeSH (Llo2327)
分子名称: CHLORIDE ION, LeSH (Llo2327)
著者Kaneko, T, Li, S.S.C.
登録日2018-07-29
公開日2018-11-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
7MP3
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Grb7-SH2 domain in complex with bicyclic peptide B8
分子名称: Growth factor receptor-bound protein 7, bicyclic peptide B8
著者Colson, R, Wilce, M.C.J, Wilce, J.A.
登録日2021-05-04
公開日2022-02-02
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability.
Biomedicines, 10, 2022
5MTJ
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Yes1-SH2 in complex with monobody Mb(Yes_1)
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ...
著者Sha, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-09
公開日2017-04-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTM
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Monobody Mb(Lck_3) bound to Lck-SH2 domain
分子名称: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
著者Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-10
公開日2017-04-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017

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