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PDB: 608 件
4ROJ
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Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
分子名称: Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
著者Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-10-28
公開日2014-12-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
TO BE PUBLISHED
3KFJ
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BU of 3kfj by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic
分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ...
著者Clements, J.H.
登録日2009-10-27
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization.
J.Am.Chem.Soc., 131, 2009
7CIO
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BU of 7cio by Molmil
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
分子名称: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha
著者Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M.
登録日2020-07-08
公開日2020-12-09
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
1MW4
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BU of 1mw4 by Molmil
Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139
分子名称: Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2
著者Ivancic, M, Lyons, B.A.
登録日2002-09-27
公開日2003-09-09
最終更新日2024-10-16
実験手法SOLUTION NMR
主引用文献Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2
J.BIOMOL.NMR, 27, 2003
6HTF
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BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
分子名称: Tyrosine-protein kinase BTK, rF10 repebody
著者Duarte, D.P, Pojer, F, Hantschel, O.
登録日2018-10-04
公開日2020-05-20
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
6E8K
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BU of 6e8k by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide
分子名称: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide
著者Kaneko, T, Li, S.S.C.
登録日2018-07-30
公開日2018-11-14
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
5KAZ
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BU of 5kaz by Molmil
Human SH2D1B structure
分子名称: SH2 domain-containing protein 1B, SULFATE ION
著者Taha, M, Nezerwa, E, Nam, H.-J.
登録日2016-06-02
公開日2017-04-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).
Protein Pept. Lett., 23, 2016
1WQU
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BU of 1wqu by Molmil
Solution structure of the human FES SH2 domain
分子名称: Proto-oncogene tyrosine-protein kinase FES/FPS
著者Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-10-02
公開日2005-06-14
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes
J.Biomol.NMR, 31, 2005
3C7I
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BU of 3c7i by Molmil
X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.
分子名称: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide
著者Benfield, A.P, Martin, S.F.
登録日2008-02-07
公開日2008-08-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 118, 2006
8CZ9
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BU of 8cz9 by Molmil
Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide
分子名称: CHLORIDE ION, JAK2 pY813 phosphopeptide, SH2B adapter protein 3
著者Morris, R, Kershaw, N.J, Babon, J.J.
登録日2022-05-24
公開日2023-05-31
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.
J.Exp.Med., 221, 2024
2LCT
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BU of 2lct by Molmil
Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide
分子名称: Proto-oncogene vav, Tyrosine-protein kinase SYK
著者Chen, C, Gorenstein, N, Post, C.
登録日2011-05-09
公開日2011-06-01
最終更新日2024-11-06
実験手法SOLUTION NMR
主引用文献Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.
Mol.Cell.Biol., 31, 2011
2LNX
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BU of 2lnx by Molmil
Solution structure of Vav2 SH2 domain
分子名称: Guanine nucleotide exchange factor VAV2
著者Wu, B, Zhang, J, Wu, J, Shi, Y.
登録日2012-01-05
公開日2012-11-21
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Identification and structural basis for a novel interaction between Vav2 and Arap3.
J.Struct.Biol., 180, 2012
6R5G
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BU of 6r5g by Molmil
C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1
分子名称: ITSM, Tyrosine-protein phosphatase non-receptor type 11
著者Marasco, M.
登録日2019-03-25
公開日2020-02-05
最終更新日2024-10-09
実験手法SOLUTION NMR
主引用文献Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
6ROZ
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BU of 6roz by Molmil
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif
分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM)
著者Krausze, J, Sikorska, J, Carlomagno, T.
登録日2019-05-13
公開日2020-02-19
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
5GJI
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BU of 5gji by Molmil
PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex
分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ...
著者Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M.
登録日2016-06-30
公開日2016-12-14
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
5GJH
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BU of 5gjh by Molmil
Gads SH2 domain/CD28-derived peptide complex
分子名称: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28
著者Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M.
登録日2016-06-30
公開日2016-12-14
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
5MTN
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BU of 5mtn by Molmil
Monobody Mb(Lck_1) bound to Lck-Sh2
分子名称: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck
著者Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-10
公開日2017-04-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
2MK2
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BU of 2mk2 by Molmil
Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A
分子名称: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
著者Yang, Y, Ramelot, T.A, Janjua, H, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG)
登録日2014-01-23
公開日2014-03-05
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A.
To be Published
3EAZ
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BU of 3eaz by Molmil
Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant.
分子名称: Tyrosine-protein kinase CSK
著者Liu, D, Seidel, R.D, Cowburn, D.
登録日2008-08-26
公開日2009-11-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
5MTJ
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BU of 5mtj by Molmil
Yes1-SH2 in complex with monobody Mb(Yes_1)
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ...
著者Sha, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-09
公開日2017-04-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTM
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Monobody Mb(Lck_3) bound to Lck-SH2 domain
分子名称: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
著者Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-10
公開日2017-04-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
6SM5
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BU of 6sm5 by Molmil
MbC/SHP1-C-SH2 complex
分子名称: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6
著者Mann, G, Hantschel, O.
登録日2019-08-21
公開日2021-01-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献MbC/SHP1-C-SH2 complex
To Be Published
6PXC
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BU of 6pxc by Molmil
N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide
分子名称: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP
著者Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
登録日2019-07-25
公開日2019-12-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
6PXB
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BU of 6pxb by Molmil
N-Terminal SH2 domain of the p120RasGAP
分子名称: Ras GTPase-activating protein 1
著者Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
登録日2019-07-25
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.747 Å)
主引用文献Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
6ROY
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BU of 6roy by Molmil
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif
分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM)
著者Krausze, J, Sikorska, J, Carlomagno, T.
登録日2019-05-13
公開日2020-02-19
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020

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