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PDB: 61 件
3R63
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BU of 3r63 by Molmil
Structure of ERK2 (SPE) mutant (S246E)
分子名称: Mitogen-activated protein kinase 1
著者Livnah, O, Karamansha, Y.
登録日2011-03-21
公開日2011-08-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation.
Mol.Cell.Biol., 31, 2011
6RFO
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BU of 6rfo by Molmil
ERK2 MAP kinase with the activation loop of p38alpha
分子名称: Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 14,Mitogen-activated protein kinase 1
著者Livnah, O, Eitan-Wexler, M.
登録日2019-04-15
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop.
J.Biol.Chem., 295, 2020
6RFP
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BU of 6rfp by Molmil
ERK2 MAP kinase with mutations at Helix-G
分子名称: Mitogen-activated protein kinase 1
著者Livnah, O, Eitan-Wexler, M.
登録日2019-04-16
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop.
J.Biol.Chem., 295, 2020
4XP2
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BU of 4xp2 by Molmil
Crystal structure of ERK2 in complex with an inhibitor
分子名称: 1-phenyl-1H-1,2,4-triazole-3,5-diamine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ...
著者Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
登録日2015-01-16
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.748 Å)
主引用文献Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
4XP3
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BU of 4xp3 by Molmil
Crystal structure of ERK2 in complex with an inhibitor
分子名称: 2-amino-1,9-dihydro-6H-purine-6-thione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ...
著者Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
登録日2015-01-16
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.782 Å)
主引用文献Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
4XNE
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BU of 4xne by Molmil
Crystal structure of ERK2 in complex with an inhibitor
分子名称: 1-phenyl-1H-1,2,4-triazole-3,5-diamine, Mitogen-activated protein kinase 1, SULFATE ION
著者Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
登録日2015-01-15
公開日2015-08-12
最終更新日2015-08-19
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
4GSB
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BU of 4gsb by Molmil
Monoclinic crystal form of the apo-ERK2
分子名称: GLYCEROL, Mitogen-activated protein kinase 1, SULFATE ION, ...
著者Pozharski, E, Zhang, J, Shapiro, P.
登録日2012-08-27
公開日2012-09-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Monoclinic crystal form of the apo-ERK2
TO BE PUBLISHED
4GVA
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BU of 4gva by Molmil
ADP-bound form of the ERK2 kinase
分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Mitogen-activated protein kinase 1
著者Pozharski, E, Zhang, J, Shapiro, P.
登録日2012-08-30
公開日2012-09-12
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献ADP-bound form of the ERK2 kinase
TO BE PUBLISHED
6CPW
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BU of 6cpw by Molmil
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology
分子名称: (3S)-N-[3-(4-fluorophenyl)-1H-indazol-5-yl]-3-(methylsulfanyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION
著者Hruza, A, Hruza, A.
登録日2018-03-14
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.
Bioorg. Med. Chem. Lett., 28, 2018
6FJB
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BU of 6fjb by Molmil
Crystal structure of ERK2 in complex with an adenosine derivative
分子名称: 5'-O-prop-2-yn-1-yladenosine, Mitogen-activated protein kinase 1, SULFATE ION
著者Gelin, M, Labesse, G.
登録日2018-01-22
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of ERK2 in complex with an adenosine derivative
To be published
6FJZ
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BU of 6fjz by Molmil
Crystal structure of ERK2 in complex with an adenosine derivative
分子名称: (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-prop-2-ynyl-oxolane-2-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION
著者Gelin, M, Labesse, G.
登録日2018-01-23
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.864 Å)
主引用文献Crystal structure of ERK2 in complex with an adenosine derivative
To be published
4I5H
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BU of 4i5h by Molmil
Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor
分子名称: Mitogen-activated protein kinase 1, N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide
著者Hari, S.B, Maly, D.J, Merritt, E.A.
登録日2012-11-28
公開日2013-07-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Sequence determinants of a specific inactive protein kinase conformation.
Chem.Biol., 20, 2013
6NBS
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BU of 6nbs by Molmil
WT ERK2 with compound 2507-8
分子名称: (5S)-5-benzyl-4,5-dihydro-1H-imidazol-2-amine, GLYCEROL, Mitogen-activated protein kinase 1, ...
著者Sammons, R.M, Perry, N.A, Cho, E.J, Kaoud, T.S, Zamora-Olivares, D.P, Piserchio, A, Houghten, R.A, Giulianotti, M, Li, Y, Debevec, G, Gurevich, V.V, Ghose, R, Iverson, T.M, Dalby, K.N.
登録日2018-12-10
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.
Acs Chem.Biol., 14, 2019
7UGB
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BU of 7ugb by Molmil
Crystal structure of rat ERK2 complexed with docking peptide from ISG20
分子名称: Interferon-stimulated gene 20 kDa protein, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Torres Robles, J, Stiegler, A.L, Boggon, T.J, Turk, B.E.
登録日2022-03-24
公開日2023-03-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献To be determined
To Be Published
2GPH
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BU of 2gph by Molmil
Docking motif interactions in the MAP kinase ERK2
分子名称: Mitogen-activated protein kinase 1, Tyrosine-protein phosphatase non-receptor type 7
著者Zhou, T, Sun, L, Humphreys, J, Goldsmith, E.J.
登録日2006-04-17
公開日2006-07-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2.
Structure, 14, 2006
6FLV
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BU of 6flv by Molmil
Crystal structure of ERK2 in complex with an adenosine derivative
分子名称: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ...
著者Gelin, M, Labesse, G.
登録日2018-01-29
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献None
To be published
6FN5
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BU of 6fn5 by Molmil
Crystal structure of ERK2 in complex with an adenosine derivative
分子名称: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ...
著者Gelin, M, Labesse, G.
登録日2018-02-02
公開日2019-03-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.932 Å)
主引用文献None
To be published
3O71
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BU of 3o71 by Molmil
Crystal structure of ERK2/DCC peptide complex
分子名称: Mitogen-activated protein kinase 1, Peptide of Deleted in Colorectal Cancer, THIOCYANATE ION
著者Ma, W.F, Shang, Y, Wei, Z.Y, Wen, W.Y, Wang, W.N, Zhang, M.J.
登録日2010-07-30
公開日2011-06-15
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase
Structure, 18, 2010
4XOZ
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BU of 4xoz by Molmil
Crystal structure of ERK2 in complex with an inhibitor
分子名称: Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION
著者Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
登録日2015-01-16
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
3ZU7
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BU of 3zu7 by Molmil
Crystal structure of a designed selected Ankyrin Repeat protein in complex with the MAP kinase ERK2
分子名称: DESIGNED ANKYRIN REPEAT PROTEIN, MITOGEN-ACTIVATED PROTEIN KINASE 1
著者Kummer, L, Mittl, P.R, Pluckthun, A.
登録日2011-07-16
公開日2012-06-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Proc.Natl.Acad.Sci.USA, 109, 2012
4S30
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BU of 4s30 by Molmil
ERK2 intrinsically active mutant (I84A)
分子名称: Mitogen-activated protein kinase 1
著者Livnah, O, Karamansha, Y.
登録日2015-01-26
公開日2016-01-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Multiple mechanisms render Erk proteins MEK-independent
To be Published
4XOY
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BU of 4xoy by Molmil
Crystal structure of ERK2 in complex with an inhibitor
分子名称: 2-amino-1,9-dihydro-6H-purine-6-thione, Mitogen-activated protein kinase 1, SULFATE ION
著者Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
登録日2015-01-16
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
6OTS
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BU of 6ots by Molmil
Rat ERK2 E320K
分子名称: Mitogen-activated protein kinase 1
著者Taylor, C.A, Cormier, K.W, Juang, Y.-C, Goldsmith, E.J, Cobb, M.H.
登録日2019-05-03
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
3ERK
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BU of 3erk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025
分子名称: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, EXTRACELLULAR REGULATED KINASE 2
著者Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
登録日1998-07-09
公開日1999-07-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
4ERK
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BU of 4erk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE
分子名称: EXTRACELLULAR REGULATED KINASE 2, OLOMOUCINE, SULFATE ION
著者Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
登録日1998-07-09
公開日1999-07-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998

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