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PDB: 41 件
4ONM
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BU of 4onm by Molmil
Crystal structure of human Mms2/Ubc13 - NSC697923
分子名称: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran, GLYCEROL, Ubiquitin-conjugating enzyme E2 N, ...
著者Hodge, C.D, Edwards, R.A, Glover, J.N.M.
登録日2014-01-28
公開日2015-05-06
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.
Acs Chem.Biol., 10, 2015
4ONL
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BU of 4onl by Molmil
Crystal structure of human Mms2/Ubc13_D81N, R85S, A122V, N123P
分子名称: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Hodge, C.D, Edwards, R.A, Glover, J.N.M.
登録日2014-01-28
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.
Acs Chem.Biol., 10, 2015
5YWR
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BU of 5ywr by Molmil
Crystal Structure of RING E3 ligase ZNRF1 in complex with Ube2N (Ubc13)
分子名称: E3 ubiquitin-protein ligase ZNRF1, FORMIC ACID, TRIETHYLENE GLYCOL, ...
著者Behera, A.P, Naskar, P, Datta, A.B.
登録日2017-11-30
公開日2018-06-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.
Biochem. J., 475, 2018
4ONN
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BU of 4onn by Molmil
Crystal structure of human Mms2/Ubc13 - BAY 11-7082
分子名称: 3-[(4-methylphenyl)sulfonyl]prop-2-enenitrile, GLYCEROL, Ubiquitin-conjugating enzyme E2 N, ...
著者Hodge, C.D, Edwards, R.A, Glover, J.N.M.
登録日2014-01-28
公開日2015-05-06
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.
Acs Chem.Biol., 10, 2015
9BIV
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BU of 9biv by Molmil
Crystal Structure of Ubc13 with a New Active Site Loop Conformation
分子名称: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Farraj, R.A, Edwards, R.A, Glover, J.N.M.
登録日2024-04-24
公開日2024-05-08
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Crystal Structure of Ubc13 with a New Active Site Loop Conformation
To Be Published
4DHI
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BU of 4dhi by Molmil
Structure of C. elegans OTUB1 bound to human UBC13
分子名称: Ubiquitin thioesterase otubain-like, Ubiquitin-conjugating enzyme E2 N
著者Wiener, R, Zhang, X, Wang, T, Wolberger, C.
登録日2012-01-27
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The mechanism of OTUB1-mediated inhibition of ubiquitination.
Nature, 483, 2012
4NR3
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BU of 4nr3 by Molmil
Crystal Structure of a human Mms2/Ubc13 L121G mutant
分子名称: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Hodge, C.D, Edwards, R.A, Glover, J.N.M.
登録日2013-11-26
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
J.Am.Chem.Soc., 136, 2014
1J7D
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BU of 1j7d by Molmil
Crystal Structure of hMms2-hUbc13
分子名称: MMS2, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA
著者Moraes, T.F, Edwards, R.A, McKenna, S, Pashushok, L, Xiao, W, Glover, J.N.M, Ellison, M.J.
登録日2001-05-16
公開日2001-08-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13.
Nat.Struct.Biol., 8, 2001
4NRG
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BU of 4nrg by Molmil
Crystal Structure of a human Mms2/Ubc13 D118G mutant
分子名称: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Hodge, C.D, Edwards, R.A, Glover, J.N.M.
登録日2013-11-26
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
J.Am.Chem.Soc., 136, 2014
6ULH
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BU of 6ulh by Molmil
Structure of MavC in complex with its substrate in R3 spacegroup
分子名称: LPG2147 (MavC), Ubiquitin, Ubiquitin-conjugating enzyme E2 N
著者Iyer, S, Puvar, K, Das, C.
登録日2019-10-08
公開日2020-05-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.968 Å)
主引用文献Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Nat Commun, 11, 2020
4TKP
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BU of 4tkp by Molmil
Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor
分子名称: SULFATE ION, Tripartite motif-containing protein 5, Ubiquitin-conjugating enzyme E2 N, ...
著者Johnson, R, Taylor, A.B, Hart, P.J, Ivanov, D.N.
登録日2014-05-27
公開日2015-07-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献RING Dimerization Links Higher-Order Assembly of TRIM5 alpha to Synthesis of K63-Linked Polyubiquitin.
Cell Rep, 12, 2015
6P5B
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BU of 6p5b by Molmil
Crystal Structure of MavC in Complex with Ub-UbE2N
分子名称: MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N
著者Puvar, K, Iyer, S, Negron Teron, K.I, Das, C.
登録日2019-05-30
公開日2020-05-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Nat Commun, 11, 2020
3HCT
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BU of 3hct by Molmil
Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group
分子名称: TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION
著者Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H.
登録日2009-05-06
公開日2009-05-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献E2 interaction and dimerization in the crystal structure of TRAF6.
Nat.Struct.Mol.Biol., 16, 2009
7BBD
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BU of 7bbd by Molmil
Crystal structure of monoubiquitinated TRIM21 RING (Ub-RING) In complex with ubiquitin charged Ube2N (Ube2N~Ub) and Ube2V2
分子名称: Polyubiquitin-B,E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, ...
著者Kiss, L, Neuhaus, D, James, L.C.
登録日2020-12-17
公開日2021-01-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
5AIU
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BU of 5aiu by Molmil
A complex of RNF4-RING domain, Ubc13-Ub (isopeptide crosslink)
分子名称: 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF4, POLYUBIQUITIN-C, ...
著者Branigan, E, Naismith, J.H.
登録日2015-02-17
公開日2015-07-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structural Basis for the Ring Catalyzed Synthesis of K63 Linked Ubiquitin Chains
Nat.Struct.Mol.Biol., 22, 2015
4IP3
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BU of 4ip3 by Molmil
Complex structure of OspI and Ubc13
分子名称: ORF169b, Ubiquitin-conjugating enzyme E2 N
著者Fu, P, Jin, M, Zhang, X, Xu, L, Xia, Z, Zhu, Y.
登録日2013-01-09
公開日2013-03-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure Analysis of Ubc13 Inactivation
To be Published
4NRI
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BU of 4nri by Molmil
Crystal Structure of a human Mms2/Ubc13 A122G mutant
分子名称: GLYCEROL, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Hodge, C.D, Edwards, R.A, Glover, J.N.M.
登録日2013-11-26
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.
J.Am.Chem.Soc., 136, 2014
6UMS
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BU of 6ums by Molmil
Crystal structure of MavC in complex with its substrate mimic in C222(1) space group
分子名称: MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N
著者Iyer, S, Puvar, K, Das, C.
登録日2019-10-10
公開日2020-05-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.344 Å)
主引用文献Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Nat Commun, 11, 2020
4DHJ
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BU of 4dhj by Molmil
The structure of a ceOTUB1 ubiquitin aldehyde UBC13~Ub complex
分子名称: Ubiquitin, Ubiquitin aldehyde, Ubiquitin thioesterase otubain-like, ...
著者Wiener, R, Zhang, X, Wang, T, Wolberger, C.
登録日2012-01-27
公開日2012-02-22
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The mechanism of OTUB1-mediated inhibition of ubiquitination.
Nature, 483, 2012
6KG6
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BU of 6kg6 by Molmil
Crystal structure of MavC/UBE2N-Ub complex
分子名称: MavC, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 N
著者Wang, Y, Huang, Y, Chang, M, Feng, Y.
登録日2019-07-10
公開日2020-04-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.
Nat Commun, 11, 2020
5EYA
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BU of 5eya by Molmil
TRIM25 RING domain in complex with Ubc13-Ub conjugate
分子名称: Polyubiquitin-B, Tripartite motif-containing 25 variant, Ubiquitin-conjugating enzyme E2 N, ...
著者Pornillos, O, Sanchez, J.G.
登録日2015-11-24
公開日2016-08-17
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.
Cell Rep, 16, 2016
6JKY
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BU of 6jky by Molmil
Crystal structure of MvcA-UBE2N-Ub complex from Legionella pneumophila
分子名称: MvcA, Ub, Ubiquitin-conjugating enzyme E2 N
著者Ouyang, S.Y, Guan, H.
登録日2019-03-03
公開日2019-12-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.454 Å)
主引用文献Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.
Embo J., 39, 2020
6LP2
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BU of 6lp2 by Molmil
Structure of Lpg2148/UBE2N-Ub complex
分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 N, Uncharacterized protein lpg2148
著者Feng, Y, Wang, Y, Huang, Y, Li, D.
登録日2020-01-08
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.479 Å)
主引用文献Structure of Lpg2148/UBE2N-Ub complex
To Be Published
7BBF
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BU of 7bbf by Molmil
Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2
分子名称: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
著者Kiss, L, Neuhaus, D, James, L.C.
登録日2020-12-17
公開日2021-01-27
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
6D6I
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BU of 6d6i by Molmil
Ube2V1 in complex with ubiquitin variant Ubv.V1.1 and Ube2N/Ubc13
分子名称: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1, Ubv.V1.1
著者Ceccarelli, D.F, Garg, P, Keszei, A, Sidhu, S, Sicheri, F.
登録日2018-04-21
公開日2019-07-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.551 Å)
主引用文献Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes.
J.Mol.Biol., 432, 2020

 

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