5AHJ
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![BU of 5ahj by Molmil](/molmil-images/mine/5ahj) | Yeast 20S proteasome in complex with Macyranone A | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 20S PROTEASOME, CHLORIDE ION, ... | 著者 | Etzbach, L, Plaza, A, Dubiella, C, Groll, M, Kaiser, M, Mueller, R. | 登録日 | 2015-02-06 | 公開日 | 2015-02-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome. J.Am.Chem.Soc., 137, 2015
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4QVL
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![BU of 4qvl by Molmil](/molmil-images/mine/4qvl) | yCP in complex with bortezomib | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-15 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QZ7
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![BU of 4qz7 by Molmil](/molmil-images/mine/4qz7) | yCP beta5-A50V mutant in complex with the epoxyketone inhibitor ONX 0914 | 分子名称: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-27 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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3DY4
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![BU of 3dy4 by Molmil](/molmil-images/mine/3dy4) | Crystal structure of yeast 20S proteasome in complex with spirolactacystin | 分子名称: | Omuralide, open form, Proteasome component C1, ... | 著者 | Groll, M, Balskus, E, Jacobsen, E. | 登録日 | 2008-07-25 | 公開日 | 2008-11-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural analysis of spiro beta-lactone proteasome inhibitors. J.Am.Chem.Soc., 130, 2008
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4HRD
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![BU of 4hrd by Molmil](/molmil-images/mine/4hrd) | Crystal structure of yeast 20S proteasome in complex with the natural product carmaphycin A | 分子名称: | N-[(2S)-1-({(2S)-1-{[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]amino}-4-[(R)-methylsulfinyl]-1-oxobutan-2-yl}amino)-3-methyl-1-oxobutan-2-yl]hexanamide, Proteasome component C1, Proteasome component C11, ... | 著者 | Trivella, D.B.B, Stein, M, Groll, M. | 登録日 | 2012-10-27 | 公開日 | 2014-01-29 | 最終更新日 | 2014-07-02 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem.Biol., 21, 2014
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5BXN
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![BU of 5bxn by Molmil](/molmil-images/mine/5bxn) | |
6HVX
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![BU of 6hvx by Molmil](/molmil-images/mine/6hvx) | Yeast 20S proteasome in complex with 4 | 分子名称: | (2~{S})-~{N}-[(2~{S})-1-[[(2~{S})-1-[4-(aminomethyl)phenyl]-4-methylsulfonyl-butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-2-[[(2~{S})-2-azido-3-phenyl-propanoyl]amino]-4-methyl-pentanamide, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Huber, E.M, Groll, M. | 登録日 | 2018-10-11 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. J.Med.Chem., 62, 2019
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4QWK
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![BU of 4qwk by Molmil](/molmil-images/mine/4qwk) | yCP beta5-A49T-A50V-double mutant in complex with carfilzomib | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-16 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4HRC
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![BU of 4hrc by Molmil](/molmil-images/mine/4hrc) | Crystal structure of yeast 20S proteasome in complex with epoxyketone carmaphycin analogue 3 | 分子名称: | N-hexanoyl-L-valyl-N~1~-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-N~5~,N~5~-dimethyl-L-glutamamide, Proteasome component C1, Proteasome component C11, ... | 著者 | Trivella, D.B.B, Stein, M, Groll, M. | 登録日 | 2012-10-27 | 公開日 | 2014-01-29 | 最終更新日 | 2014-07-02 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem.Biol., 21, 2014
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8U6Y
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![BU of 8u6y by Molmil](/molmil-images/mine/8u6y) | Preholo-Proteasome from Beta 3 D205 deletion | 分子名称: | Proteasome assembly chaperone 2, Proteasome chaperone 1, Proteasome maturation factor UMP1, ... | 著者 | Walsh Jr, R.M, Rawson, S, Velez, B, Blickling, M, Razi, A, Hanna, J. | 登録日 | 2023-09-14 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of autocatalytic activation during proteasome assembly. Nat.Struct.Mol.Biol., 2024
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5FGD
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![BU of 5fgd by Molmil](/molmil-images/mine/5fgd) | |
6HWA
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![BU of 6hwa by Molmil](/molmil-images/mine/6hwa) | Yeast 20S proteasome in complex with 43 | 分子名称: | (2~{S})-~{N}-[(2~{S},3~{R})-1-[(4~{a}~{S},8~{a}~{S})-1,2,3,4,4~{a},5,6,7,8,8~{a}-decahydronaphthalen-2-yl]-4-methyl-3,4-bis(oxidanyl)pentan-2-yl]-3-(4-methoxyphenyl)-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Huber, E.M, Groll, M. | 登録日 | 2018-10-11 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. J.Med.Chem., 62, 2019
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5FGH
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![BU of 5fgh by Molmil](/molmil-images/mine/5fgh) | |
7NAN
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![BU of 7nan by Molmil](/molmil-images/mine/7nan) | Human 20S proteasome core particle | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Zhao, J, Makhija, S, Huang, B, Cheng, Y. | 登録日 | 2021-06-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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4QZ5
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![BU of 4qz5 by Molmil](/molmil-images/mine/4qz5) | yCP beta5-A49T-mutant in complex with ONX 0914 | 分子名称: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-27 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QW4
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![BU of 4qw4 by Molmil](/molmil-images/mine/4qw4) | yCP in complex with carfilzomib | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-16 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QVV
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![BU of 4qvv by Molmil](/molmil-images/mine/4qvv) | yCP beta5-A49V mutant in complex with bortezomib | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-16 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QVM
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![BU of 4qvm by Molmil](/molmil-images/mine/4qvm) | yCP beta5-M45A mutant in complex with bortezomib | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-15 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4GK7
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![BU of 4gk7 by Molmil](/molmil-images/mine/4gk7) | yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera | 分子名称: | Proteasome component C1, Proteasome component C11, Proteasome component C5, ... | 著者 | Groll, M, Stein, M.L, Bachmann, A. | 登録日 | 2012-08-10 | 公開日 | 2012-08-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells. Biochemistry, 51, 2012
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6HW8
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![BU of 6hw8 by Molmil](/molmil-images/mine/6hw8) | Yeast 20S proteasome in complex with 39 | 分子名称: | (2~{S})-~{N}-[(3~{S},4~{R})-1-cyclohexyl-5-methyl-4,5-bis(oxidanyl)hexan-3-yl]-3-(4-methoxyphenyl)-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Huber, E.M, Groll, M. | 登録日 | 2018-10-11 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. J.Med.Chem., 62, 2019
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4R00
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![BU of 4r00 by Molmil](/molmil-images/mine/4r00) | yCP beta5-C52F mutant in complex with Omuralide | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Omuralide, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-29 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QV6
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![BU of 4qv6 by Molmil](/molmil-images/mine/4qv6) | yCP beta5-A49V mutant | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-14 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QXJ
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![BU of 4qxj by Molmil](/molmil-images/mine/4qxj) | yCP beta5-M45A mutant in complex with the epoxyketone inhibitor ONX 0914 | 分子名称: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | 登録日 | 2014-07-21 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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3SHJ
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![BU of 3shj by Molmil](/molmil-images/mine/3shj) | Proteasome in complex with hydroxyurea derivative HU10 | 分子名称: | 1-hydroxy-1-[(2R)-4-{3-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yloxy]phenyl}but-3-yn-2-yl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proteasome component C1, ... | 著者 | Gallastegui, N, Beck, P, Arciniega, M, Hillebrand, S, Huber, R, Groll, M. | 登録日 | 2011-06-16 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Hydroxyureas as noncovalent proteasome inhibitors. Angew.Chem.Int.Ed.Engl., 51, 2012
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4J70
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![BU of 4j70 by Molmil](/molmil-images/mine/4j70) | Yeast 20S proteasome in complex with the belactosin derivative 3e | 分子名称: | Proteasome component C1, Proteasome component C11, Proteasome component C5, ... | 著者 | Kawamura, S, Unno, Y, List, A, Tanaka, M, Sasaki, T, Arisawa, M, Asai, A, Groll, M, Shuto, S. | 登録日 | 2013-02-12 | 公開日 | 2013-04-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action. J.Med.Chem., 56, 2013
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