5AHJ

Yeast 20S proteasome in complex with Macyranone A

Summary for 5AHJ

• Entry DOI: 10.2210/pdb5ahj/pdb
• Descriptor: PROTEASOME SUBUNIT ALPHA TYPE-2, PROTEASOME SUBUNIT BETA TYPE-4, PROTEASOME SUBUNIT BETA TYPE-5, ... (19 entities in total)
• Functional Keywords: hydrolase, proteasome, natural product, target identification, inhibition, binding analysis
• Biological source: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 732906.57

Authors

Etzbach, L.,Plaza, A.,Dubiella, C.,Groll, M.,Kaiser, M.,Mueller, R. (deposition date: 2015-02-06, release date: 2015-02-18, Last modification date: 2024-01-10)

• Primary citation: Keller, L.,Plaza, A.,Dubiella, C.,Groll, M.,Kaiser, M.,Muller, R.; Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome.; J.Am.Chem.Soc., 137:8121-, 2015; PubMed: 26050527; DOI: 10.1021/JACS.5B03833

Experimental method

X-RAY DIFFRACTION (2.8 Å)