5AHJ
Yeast 20S proteasome in complex with Macyranone A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | PROTEASOME SUBUNIT ALPHA TYPE-2 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT Y7, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y7, PROTEASOME COMPONENT Y7, PROTEINASE YSCE SUBUNIT 7 |
| 2 | B, P (B, P) | PROTEASOME SUBUNIT ALPHA TYPE-3 | polymer | 258 | 28748.2 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT Y13, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y13, PROTEASOME COMPONENT Y13, PROTEINASE YSCE SUBUNIT 13 |
| 3 | C, Q (C, Q) | PROTEASOME SUBUNIT ALPHA TYPE-4 | polymer | 254 | 28478.1 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PRE6, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE6, PROTEASOME COMPONENT PRE6, PROTEINASE YSCE SUBUNIT PRE6 |
| 4 | D, R (D, R) | PROTEASOME SUBUNIT ALPHA TYPE-5 | polymer | 260 | 28649.1 | 2 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PUP2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP2, PROTEASOME COMPONENT PUP2, PROTEINASE YSCE SUBUNIT PUP2 |
| 5 | E, S (E, S) | PROTEASOME SUBUNIT ALPHA TYPE-6 | polymer | 234 | 25634.0 | 2 | UniProt (P40302) Pfam (PF00227) Pfam (PF10584) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PRE5, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE5, PROTEASOME COMPONENT PRE5, PROTEINASE YSCE SUBUNIT PRE5 |
| 6 | F, T (F, T) | PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 | polymer | 288 | 31575.1 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT C1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C1, PROTEASOME COMPONENT C1, PROTEINASE YSCE SUBUNIT 1 |
| 7 | G, U (G, U) | PROTEASOME SUBUNIT ALPHA TYPE-1 | polymer | 252 | 28033.8 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT C7-ALPHA, MULTICATALYTIC ENDOPEPTIDASE COMPLEX C7, PROTEASOME COMPONENT C7-ALPHA, PROTEASOME COMPONENT Y8, PROTEINASE YSCE SUBUNIT 7, SCL1 SUPPRESSOR PROTEIN |
| 8 | H, V (H, V) | PROTEASOME SUBUNIT BETA TYPE-2 | polymer | 232 | 25114.5 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PUP1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP1, PROTEASOME COMPONENT PUP1, PROTEINASE YSCE SUBUNIT PUP1 |
| 9 | I, W (I, W) | PROTEASOME SUBUNIT BETA TYPE-3 | polymer | 205 | 22627.8 | 2 | UniProt (P25451) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PUP3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP3, PROTEASOME COMPONENT PUP3 |
| 10 | J, X (J, X) | PROTEASOME SUBUNIT BETA TYPE-4 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT C11, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C11, PROTEASOME COMPONENT C11, PROTEINASE YSCE SUBUNIT 11 |
| 11 | K, Y (K, Y) | PROTEASOME SUBUNIT BETA TYPE-5 | polymer | 212 | 23325.2 | 2 | UniProt (P30656) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PRE2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE2, PROTEASOME COMPONENT PRE2, PROTEINASE YSCE SUBUNIT PRE2 |
| 12 | L, Z (L, Z) | PROTEASOME SUBUNIT BETA TYPE-6 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C5, PROTEASOME COMPONENT C5 |
| 13 | AA, M (M, a) | PROTEASOME SUBUNIT BETA TYPE-7 | polymer | 233 | 25945.5 | 2 | UniProt (P30657) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PRE4, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE4, PROTEASOME COMPONENT PRE4, PROTEINASE YSCE SUBUNIT PRE4 |
| 14 | BA, N (N, b) | 20S PROTEASOME | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | MACROPAIN SUBUNIT PRE3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE3, PROTEASOME COMPONENT PRE3, PROTEINASE YSCE SUBUNIT PRE3 |
| 15 | CA, FA, HA, JA, NA... (G, I, K, N, V...) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 16 | DA, LA, MA, UA (G, N, U, b) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 17 | EA, IA, KA, OA, RA... (H, K, N, V, Y...) | N-[(2S)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-2-methyl-3-oxopropanoyl]-L-threonyl-N-[(3S,4S)-1,3-dihydroxy-6-methylheptan-4-yl]-L-allothreoninamide | non-polymer | 610.7 | 6 | Chemie (7IM) | |||
| 18 | GA, PA (K, Y) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 19 | AB, BB, CB, DB, EB... (F, G, H, I, J...) | water | water | 18.0 | 333 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 728540.0 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 4366.6 | |
| All* | Total formula weight | 732906.6 |
