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4GK7

yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera

Summary for 4GK7
Entry DOI10.2210/pdb4gk7/pdb
Related1RYP 2ZCY 3BDM
Related PRD IDPRD_001047
DescriptorProteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywordsproteasome, cancer, protein degradation, inhibition, natural product derivative, ntn-hydrolase, hydrolase-hydrolase inhibitor complex, 12-membered dipeptide-macrolactam, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
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Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains34
Total formula weight707510.63
Authors
Groll, M.,Stein, M.L.,Bachmann, A. (deposition date: 2012-08-10, release date: 2012-08-29, Last modification date: 2023-11-15)
Primary citationArcher, C.R.,Groll, M.,Stein, M.L.,Schellenberg, B.,Clerc, J.,Kaiser, M.,Kondratyuk, T.P.,Pezzuto, J.M.,Dudler, R.,Bachmann, A.S.
Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells.
Biochemistry, 51:6880-6888, 2012
Cited by
PubMed: 22870914
DOI: 10.1021/bi300841r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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