4GK7
yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera
Summary for 4GK7
Entry DOI | 10.2210/pdb4gk7/pdb |
Related | 1RYP 2ZCY 3BDM |
Related PRD ID | PRD_001047 |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total) |
Functional Keywords | proteasome, cancer, protein degradation, inhibition, natural product derivative, ntn-hydrolase, hydrolase-hydrolase inhibitor complex, 12-membered dipeptide-macrolactam, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 34 |
Total formula weight | 707510.63 |
Authors | Groll, M.,Stein, M.L.,Bachmann, A. (deposition date: 2012-08-10, release date: 2012-08-29, Last modification date: 2023-11-15) |
Primary citation | Archer, C.R.,Groll, M.,Stein, M.L.,Schellenberg, B.,Clerc, J.,Kaiser, M.,Kondratyuk, T.P.,Pezzuto, J.M.,Dudler, R.,Bachmann, A.S. Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells. Biochemistry, 51:6880-6888, 2012 Cited by PubMed: 22870914DOI: 10.1021/bi300841r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report