3SHJ

Proteasome in complex with hydroxyurea derivative HU10

Summary for 3SHJ

• Entry DOI: 10.2210/pdb3shj/pdb
• Related: 1RYP
• Descriptor: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total)
• Functional Keywords: ubiquitin, drug development, cancer, immunology, protein degradation, unfolded protein substrates, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 705305.60

Authors

Gallastegui, N.,Beck, P.,Arciniega, M.,Hillebrand, S.,Huber, R.,Groll, M. (deposition date: 2011-06-16, release date: 2011-12-07, Last modification date: 2023-09-13)

• Primary citation: Gallastegui, N.,Beck, P.,Arciniega, M.,Huber, R.,Hillebrand, S.,Groll, M.; Hydroxyureas as noncovalent proteasome inhibitors.; Angew.Chem.Int.Ed.Engl., 51:247-249, 2012; PubMed: 22105886; DOI: 10.1002/anie.201106010

Experimental method

X-RAY DIFFRACTION (2.8 Å)