3SHJ

Proteasome in complex with hydroxyurea derivative HU10

Summary for 3SHJ

Related1RYP
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (17 entities in total)
Functional Keywordsubiquitin, drug development, cancer, immunology, protein degradation, unfolded protein substrates, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight705305.6
Authors
Gallastegui, N.,Beck, P.,Arciniega, M.,Hillebrand, S.,Huber, R.,Groll, M. (deposition date: 2011-06-16, release date: 2011-12-07, Last modification date: 2012-01-18)
Primary citation
Gallastegui, N.,Beck, P.,Arciniega, M.,Huber, R.,Hillebrand, S.,Groll, M.
Hydroxyureas as noncovalent proteasome inhibitors.
Angew.Chem.Int.Ed.Engl., 51:247-249, 2012
PubMed: 22105886 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201106010
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.266261.5%5.2%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3shj
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Molmil generated image of 3shj
rotated about x axis by 90°
Molmil generated image of 3shj
rotated about y axis by 90°