3SHJ
Proteasome in complex with hydroxyurea derivative HU10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | Proteasome component Y7 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal alpha 2 subunit, a2, Macropain subunit Y7, Multicatalytic endopeptidase complex subunit Y7, Proteinase YSCE subunit 7 |
| 2 | B, P (B, P) | Proteasome component Y13 | polymer | 244 | 27050.4 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal alpha 3 subunit, a3, Macropain subunit Y13, Multicatalytic endopeptidase complex subunit Y13, Proteinase YSCE subunit 13 |
| 3 | C, Q (C, Q) | Proteasome component PRE6 | polymer | 241 | 26903.3 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal alpha 4 subunit, a4, Macropain subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6, Proteinase YSCE subunit PRE6 |
| 4 | D, R (D, R) | Proteasome component PUP2 | polymer | 242 | 26544.8 | 2 | UniProt (P32379) Pfam (PF00227) Pfam (PF10584) | Saccharomyces cerevisiae (yeast) | Proteasomal alpha 5 subunit, a5, Macropain subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2, Proteinase YSCE subunit PUP2 |
| 5 | E, S (E, S) | Proteasome component PRE5 | polymer | 233 | 25502.8 | 2 | UniProt (P40302) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal alpha 6 subunit, a6, Macropain subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5, Proteinase YSCE subunit PRE5 |
| 6 | F, T (F, T) | Proteasome component C1 | polymer | 244 | 26892.5 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal alpha 7 subunit, a7, Macropain subunit C1, Multicatalytic endopeptidase complex subunit C1, Proteinase YSCE subunit 1 |
| 7 | G, U (G, U) | Proteasome component C7-alpha | polymer | 243 | 27316.0 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal alpha 1 subunit, a1, Macropain subunit C7-alpha, Multicatalytic endopeptidase complex C7, Proteasome component Y8, Proteinase YSCE subunit 7, SCL1 suppressor protein |
| 8 | H, V (H, V) | Proteasome component PUP1 | polymer | 222 | 23987.3 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) | Saccharomyces cerevisiae (yeast) | Proteasomal beta 2 subunit, b2, Macropain subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1, Proteinase YSCE subunit PUP1 |
| 9 | I, W (I, W) | Proteasome component PUP3 | polymer | 204 | 22496.6 | 2 | UniProt (P25451) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal beta 3 subunit, b3, Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3 |
| 10 | J, X (J, X) | Proteasome component C11 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal beta 4 subunit, b4, Macropain subunit C11, Multicatalytic endopeptidase complex subunit C11, Proteinase YSCE subunit 11 |
| 11 | K, Y (K, Y) | Proteasome component PRE2 | polymer | 212 | 23325.2 | 2 | UniProt (P30656) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal beta 5 subunit, b5, Macropain subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2, Proteinase YSCE subunit PRE2 |
| 12 | L, Z (L, Z) | Proteasome component C5 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal beta 6 subunit, b6, Multicatalytic endopeptidase complex subunit C5 |
| 13 | AA, M (M, 1) | Proteasome component PRE4 | polymer | 233 | 25945.5 | 2 | UniProt (P30657) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal beta 7 subunit, b7, Macropain subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4, Proteinase YSCE subunit PRE4 |
| 14 | BA, N (N, 2) | Proteasome component PRE3 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) | Saccharomyces cerevisiae (yeast) | Proteasomal beta 1 subunit, b1, Macropain subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3, Proteinase YSCE subunit PRE3 |
| 15 | CA, EA (K, Y) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 16 | DA, FA (K, Y) | 1-hydroxy-1-[(2R)-4-{3-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yloxy]phenyl}but-3-yn-2-yl]urea | non-polymer | 354.4 | 2 | Chemie (H10) | |||
| 17 | AB, BB, CB, DB, EB... (U, V, W, X, Y...) | water | water | 18.0 | 1281 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 704206.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1099.4 | |
| All* | Total formula weight | 705305.6 |
