5BXN
Yeast 20S proteasome beta2-G170A mutant in complex with Bortezomib
Summary for 5BXN
Entry DOI | 10.2210/pdb5bxn/pdb |
Related | 1RYP |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, immunodeficiency, proteasome, mutant, assembly defect, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) More |
Total number of polymer chains | 28 |
Total formula weight | 733744.80 |
Authors | Huber, E.M.,Groll, M. (deposition date: 2015-06-09, release date: 2016-06-15, Last modification date: 2024-01-10) |
Primary citation | Treise, I.,Huber, E.M.,Klein-Rodewald, T.,Heinemeyer, W.,Grassmann, S.A.,Basler, M.,Adler, T.,Rathkolb, B.,Helming, L.,Andres, C.,Klaften, M.,Landbrecht, C.,Wieland, T.,Strom, T.M.,McCoy, K.D.,Macpherson, A.J.,Wolf, E.,Groettrup, M.,Ollert, M.,Neff, F.,Gailus-Durner, V.,Fuchs, H.,Hrabe de Angelis, M.,Groll, M.,Busch, D.H. Defective immuno- and thymoproteasome assembly causes severe immunodeficiency. Sci Rep, 8:5975-5975, 2018 Cited by PubMed: 29654304DOI: 10.1038/s41598-018-24199-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report