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PDB: 62 件
6YVM
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BU of 6yvm by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.13 MGy exposure
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Tittmann, K, Rindfleisch, S, Krull, M.
登録日2020-04-28
公開日2021-11-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YVN
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BU of 6yvn by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.84 MGy exposure
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Tittmann, K, Rindfleisch, S, Krull, M.
登録日2020-04-28
公開日2021-11-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YVO
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BU of 6yvo by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 3.55 MGy exposure
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Tittmann, K, Rindfleisch, S, Krull, M.
登録日2020-04-28
公開日2022-02-23
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
3EX6
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BU of 3ex6 by Molmil
D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct
分子名称: CHLORIDE ION, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ...
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
7Q1H
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BU of 7q1h by Molmil
Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution
分子名称: OROTIDINE-5'-MONOPHOSPHATE, PROLINE, SULFATE ION, ...
著者Rabe von Pappenheim, F, Kirck, L.L.
登録日2021-10-20
公開日2022-05-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
3L0K
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BU of 3l0k by Molmil
Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP
分子名称: 6-acetyluridine 5'-phosphate, GLYCEROL, Uridine 5'-monophosphate synthase
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2009-12-10
公開日2010-01-26
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3MO7
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BU of 3mo7 by Molmil
Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP
分子名称: 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL, Uridine 5'-monophosphate synthase
著者Liu, Y, Kotra, L.P, Pai, E.F.
登録日2010-04-22
公開日2011-04-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
J.Med.Chem., 54, 2011
3EWZ
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BU of 3ewz by Molmil
human orotidyl-5'-monophosphate decarboxylase in complex with 5-cyano-UMP
分子名称: 5-CYANO-URIDINE-5'-MONOPHOSPHATE, Orotidine-5'-phosphate decarboxylase, SULFATE ION
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EWX
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BU of 3ewx by Molmil
K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded to BMP
分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine-5'-phosphate decarboxylase
著者Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EX1
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BU of 3ex1 by Molmil
human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-UMP, converted to UMP
分子名称: 6-cyanouridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ...
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3G3M
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BU of 3g3m by Molmil
Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-iodo-UMP
分子名称: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase
著者Liu, Y, Tang, H.L, Bello, A.M, Poduch, E, Kotra, L.P, Pai, E.F.
登録日2009-02-02
公開日2009-03-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
J.Med.Chem., 52, 2009
2QCE
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BU of 2qce by Molmil
Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to sulfate, glycerol, and chloride
分子名称: CHLORIDE ION, GLYCEROL, SULFATE ION, ...
著者Wittmann, J, Rudolph, M.
登録日2007-06-19
公開日2007-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
Structure, 16, 2008
3EX3
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BU of 3ex3 by Molmil
human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct
分子名称: GLYCEROL, Orotidine-5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3DBP
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BU of 3dbp by Molmil
Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP
分子名称: 6-AMINOURIDINE 5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase, SULFATE ION
著者Liu, Y, To, T, Bello, A.M, Kotra, L.P, Pai, E.F.
登録日2008-06-02
公開日2009-06-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP
To be Published
3EX2
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BU of 3ex2 by Molmil
human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP
分子名称: 6-cyanouridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3EWU
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BU of 3ewu by Molmil
D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP, covalent adduct
分子名称: 6-ethyluridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ...
著者Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3BK0
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BU of 3bk0 by Molmil
Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP
分子名称: 5-CYANO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, SULFATE ION, ...
著者Liu, Y, Tang, H.L, Avina, M.E.M, Kotra, L.P, Pai, E.F.
登録日2007-12-05
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP
To be Published
2QCM
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BU of 2qcm by Molmil
Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP
分子名称: 6-(HYDROXYMETHYL)URIDINE 5'-(DIHYDROGEN PHOSPHATE), Uridine 5'-monophosphate synthase (UMP synthase)
著者Wittmann, J, Rudolph, M.
登録日2007-06-19
公開日2007-11-06
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
Structure, 16, 2008
3G3D
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BU of 3g3d by Molmil
Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP
分子名称: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, SULFATE ION, ...
著者Liu, Y, Tang, H.L, Bello, A, Poduch, E, Kotra, L, Pai, E.
登録日2009-02-02
公開日2009-03-03
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
J.Med.Chem., 52, 2009
3L0N
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BU of 3l0n by Molmil
Human orotidyl-5'-monophosphate decarboxylase in complex with 6-mercapto-UMP
分子名称: 6-sulfanyluridine-5'-phosphate, Uridine 5'-monophosphate synthase
著者Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M.
登録日2009-12-10
公開日2010-01-26
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
2QCG
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BU of 2qcg by Molmil
Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to 5-bromo-UMP
分子名称: 5-BROMO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase (UMP synthase)
著者Wittmann, J, Rudolph, M.
登録日2007-06-19
公開日2007-11-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
Structure, 16, 2008
4HKP
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BU of 4hkp by Molmil
Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide
分子名称: 5-hydroxycytidine 5'-(dihydrogen phosphate), GLYCEROL, N-hydroxycytidine 5'-(dihydrogen phosphate), ...
著者To, T.K, Kotra, L.P, Pai, E.F.
登録日2012-10-15
公開日2012-11-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist.
J.Med.Chem., 55, 2012
2P1F
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BU of 2p1f by Molmil
Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase)
分子名称: GLYCEROL, SODIUM ION, SULFATE ION, ...
著者Liu, Y, Tang, H.L, Pai, E.F.
登録日2007-03-05
公開日2007-04-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase)
TO BE PUBLISHED
3BVJ
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BU of 3bvj by Molmil
Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with XMP
分子名称: GLYCEROL, SULFATE ION, Uridine 5'-monophosphate synthase, ...
著者Liu, Y, Tang, H.L, Pai, E.F.
登録日2008-01-07
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with XMP
To be Published
4HIB
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BU of 4hib by Molmil
Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH
分子名称: CHLORIDE ION, GLYCEROL, N-hydroxycytidine 5'-(dihydrogen phosphate), ...
著者To, T.K, Kotra, L.P, Pai, E.F.
登録日2012-10-11
公開日2012-11-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist.
J.Med.Chem., 55, 2012

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件を2024-10-09に公開中

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