3EWX

K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded to BMP

Summary for 3EWX

Entry DOI	10.2210/pdb3ewx/pdb
Related	3EWU 3EWW 3EWY 3EWZ 3EX0 3EX1 3EX2 3EX3 3EX4 3EX5 3EX6
Descriptor	Orotidine-5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (4 entities in total)
Functional Keywords	decarboxylase, tim barrel, unusual catalysis, disease mutation, glycosyltransferase, lyase, multifunctional enzyme, pyrimidine biosynthesis, transferase
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	28750.03
Authors	Heinrich, D.,Wittmann, J.,Diederichsen, U.,Rudolph, M. (deposition date: 2008-10-16, release date: 2009-04-07, Last modification date: 2023-12-27)
Primary citation	Heinrich, D.,Diederichsen, U.,Rudolph, M.G. Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15:6619-6625, 2009 Cited by PubMed: 19472232 DOI: 10.1002/chem.200900397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation